(11 nodes) Nickel cation binding network (Shigella boydii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Known Interactions

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Predicted Interactions

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Your Input:
	hypB	Hydrogenase isoenzymes nickel incorporation protein HypB; Identified by match to protein family HMM PF02492; match to protein family HMM TIGR00073. (290 aa)
	hycE	Formate hydrogenlyase, subunit E; Identified by match to protein family HMM PF00329; match to protein family HMM PF00346. (569 aa)
	hypA1	Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)
	hybC	Hydrogenase-2, large subunit; Identified by match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (567 aa)
	nikR	Nickel-responsive transcriptional regulator NikR; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel. (133 aa)
	nikE	Nickel ABC transporter, ATP-binding protein NikE; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (268 aa)
	nikD	Nickel ABC transporter, ATP-binding protein NikD; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (254 aa)
	nikA	Nickel ABC transporter, periplasmic nickel-binding protein NikA; Identified by match to protein family HMM PF00496; match to protein family HMM TIGR02294. (524 aa)
	zraP	Zinc resistance-associated protein; Binds zinc. Could be an important component of the zinc- balancing mechanism; Belongs to the ZraP family. (188 aa)
	hyaB	Nickel-dependent hydrogenase 1, large subunit; Identified by match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (597 aa)
	ACD10019.1	Hydrogenase-4, G subunit; Identified by match to protein family HMM PF00329; match to protein family HMM PF00346. (571 aa)

Your Current Organism:

Shigella boydii

NCBI taxonomy Id: 344609
Other names: S. boydii CDC 3083-94, Shigella boydii BS512, Shigella boydii CDC 3083-94, Shigella boydii str. CDC 3083-94, Shigella boydii strain CDC 3083-94

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACD10019.1	hypA1	SbBS512_E2859	SbBS512_E3418	Hydrogenase-4, G subunit; Identified by match to protein family HMM PF00329; match to protein family HMM PF00346.	Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.652
ACD10019.1	hypB	SbBS512_E2859	SbBS512_E3150	Hydrogenase-4, G subunit; Identified by match to protein family HMM PF00329; match to protein family HMM PF00346.	Hydrogenase isoenzymes nickel incorporation protein HypB; Identified by match to protein family HMM PF02492; match to protein family HMM TIGR00073.	0.956
hyaB	hybC	SbBS512_E2342	SbBS512_E3421	Nickel-dependent hydrogenase 1, large subunit; Identified by match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Hydrogenase-2, large subunit; Identified by match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.907
hyaB	hypA1	SbBS512_E2342	SbBS512_E3418	Nickel-dependent hydrogenase 1, large subunit; Identified by match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.892
hyaB	hypB	SbBS512_E2342	SbBS512_E3150	Nickel-dependent hydrogenase 1, large subunit; Identified by match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Hydrogenase isoenzymes nickel incorporation protein HypB; Identified by match to protein family HMM PF02492; match to protein family HMM TIGR00073.	0.728
hybC	hyaB	SbBS512_E3421	SbBS512_E2342	Hydrogenase-2, large subunit; Identified by match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Nickel-dependent hydrogenase 1, large subunit; Identified by match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.907
hybC	hypA1	SbBS512_E3421	SbBS512_E3418	Hydrogenase-2, large subunit; Identified by match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.978
hybC	hypB	SbBS512_E3421	SbBS512_E3150	Hydrogenase-2, large subunit; Identified by match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Hydrogenase isoenzymes nickel incorporation protein HypB; Identified by match to protein family HMM PF02492; match to protein family HMM TIGR00073.	0.753
hycE	hypA1	SbBS512_E3155	SbBS512_E3418	Formate hydrogenlyase, subunit E; Identified by match to protein family HMM PF00329; match to protein family HMM PF00346.	Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.654
hycE	hypB	SbBS512_E3155	SbBS512_E3150	Formate hydrogenlyase, subunit E; Identified by match to protein family HMM PF00329; match to protein family HMM PF00346.	Hydrogenase isoenzymes nickel incorporation protein HypB; Identified by match to protein family HMM PF02492; match to protein family HMM TIGR00073.	0.967
hypA1	ACD10019.1	SbBS512_E3418	SbBS512_E2859	Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	Hydrogenase-4, G subunit; Identified by match to protein family HMM PF00329; match to protein family HMM PF00346.	0.652
hypA1	hyaB	SbBS512_E3418	SbBS512_E2342	Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	Nickel-dependent hydrogenase 1, large subunit; Identified by match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.892
hypA1	hybC	SbBS512_E3418	SbBS512_E3421	Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	Hydrogenase-2, large subunit; Identified by match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.978
hypA1	hycE	SbBS512_E3418	SbBS512_E3155	Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	Formate hydrogenlyase, subunit E; Identified by match to protein family HMM PF00329; match to protein family HMM PF00346.	0.654
hypA1	hypB	SbBS512_E3418	SbBS512_E3150	Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	Hydrogenase isoenzymes nickel incorporation protein HypB; Identified by match to protein family HMM PF02492; match to protein family HMM TIGR00073.	0.941
hypB	ACD10019.1	SbBS512_E3150	SbBS512_E2859	Hydrogenase isoenzymes nickel incorporation protein HypB; Identified by match to protein family HMM PF02492; match to protein family HMM TIGR00073.	Hydrogenase-4, G subunit; Identified by match to protein family HMM PF00329; match to protein family HMM PF00346.	0.956
hypB	hyaB	SbBS512_E3150	SbBS512_E2342	Hydrogenase isoenzymes nickel incorporation protein HypB; Identified by match to protein family HMM PF02492; match to protein family HMM TIGR00073.	Nickel-dependent hydrogenase 1, large subunit; Identified by match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.728
hypB	hybC	SbBS512_E3150	SbBS512_E3421	Hydrogenase isoenzymes nickel incorporation protein HypB; Identified by match to protein family HMM PF02492; match to protein family HMM TIGR00073.	Hydrogenase-2, large subunit; Identified by match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.753
hypB	hycE	SbBS512_E3150	SbBS512_E3155	Hydrogenase isoenzymes nickel incorporation protein HypB; Identified by match to protein family HMM PF02492; match to protein family HMM TIGR00073.	Formate hydrogenlyase, subunit E; Identified by match to protein family HMM PF00329; match to protein family HMM PF00346.	0.967
hypB	hypA1	SbBS512_E3150	SbBS512_E3418	Hydrogenase isoenzymes nickel incorporation protein HypB; Identified by match to protein family HMM PF02492; match to protein family HMM TIGR00073.	Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.941

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