STRINGSTRING
ugpB ugpB kefG kefG kefB kefB acrE acrE lptB lptB tolC tolC ACD07459.1 ACD07459.1 ACD06319.1 ACD06319.1 rbsA rbsA proV proV proX proX cysT cysT cysW cysW cysA cysA nuoA nuoA nuoB nuoB nuoE nuoE nuoG nuoG nuoH nuoH nuoI nuoI nuoJ nuoJ nuoK nuoK nuoL nuoL folK folK kefC kefC kefF kefF proW proW nuoN nuoN potG potG potH potH potI potI macA macA macB macB cudC cudC cydD cydD msbA msbA csgF csgF ACD10509.1 ACD10509.1 potC potC ACD09634.1 ACD09634.1 malF malF ACD08138.1 ACD08138.1 btuC btuC btuD btuD clcB clcB sitB_2 sitB_2 sitC_2 sitC_2 ACD06720.1 ACD06720.1 potA potA potB potB mdtA mdtA nuoM nuoM znuC znuC ACD08623.1 ACD08623.1 modF modF kdpB kdpB kdpA kdpA metN metN metI metI metQ metQ fhuB fhuB fhuC fhuC ACD08116.1 ACD08116.1 phnE phnE xylG xylG ugpC ugpC ugpE ugpE ugpA ugpA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ugpBGlycerol-3-phosphate-binding periplasmic protein precursor; Identified by match to protein family HMM PF01547. (438 aa)
kefGGlutathione-regulated potassium-efflux system ancillary protein kefG; Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB. (184 aa)
kefBGlutathione-regulated potassium-efflux system protein KefB; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (601 aa)
acrEIdentified by match to protein family HMM PF00529; match to protein family HMM TIGR01730; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (385 aa)
lptBLipopolysaccharide ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (241 aa)
tolCOuter membrane protein TolC; Identified by match to protein family HMM PF02321; match to protein family HMM TIGR01844. (495 aa)
ACD07459.1ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (236 aa)
ACD06319.1ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (225 aa)
rbsAD-ribose ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (187 aa)
proVGlycine betaine/L-proline ABC transporter, ATP binding protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00571; match to protein family HMM TIGR01186. (400 aa)
proXGlycine betaine/L-proline ABC transporter, periplasmic glycine betaine-binding protein; Identified by match to protein family HMM PF04069. (330 aa)
cysTSulfate ABC transporter, permease protein CysT; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (277 aa)
cysWSulfate ABC transporter, permease protein CysW; Identified by similarity to SP:P0AEB0; match to protein family HMM PF00528; match to protein family HMM TIGR00969; match to protein family HMM TIGR02140. (291 aa)
cysASulfate/thiosulfate ABC transporter, ATP-binding protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (365 aa)
nuoANADH-quinone oxidoreductase, A subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. (147 aa)
nuoBNADH-quinone oxidoreductase, B subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (220 aa)
nuoENADH-quinone oxidoreductase, E subunit; Identified by match to protein family HMM PF01257; match to protein family HMM TIGR01958. (166 aa)
nuoGNADH-quinone oxidoreductase, G subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (908 aa)
nuoHNADH-quinone oxidoreductase, H subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (325 aa)
nuoINADH-quinone oxidoreductase, I subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (180 aa)
nuoJNADH-quinone oxidoreductase, J subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (184 aa)
nuoKNADH-quinone oxidoreductase, K subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (100 aa)
nuoLNADH-quinone oxidoreductase, L subunit; Identified by match to protein family HMM PF00361; match to protein family HMM PF00662; match to protein family HMM TIGR01974. (613 aa)
folK2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Identified by match to protein family HMM PF01288; match to protein family HMM TIGR01498. (159 aa)
kefCGlutathione-regulated potassium-efflux system protein KefC; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (620 aa)
kefFGlutathione-regulated potassium-efflux system ancillary protein kefF; Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC; Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily. (176 aa)
proWGlycine betaine/L-proline ABC transporter, permease protein; Identified by match to protein family HMM PF00528. (354 aa)
nuoNNADH-quinone oxidoreductase, N subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (485 aa)
potGPutrescine ABC transporter, ATP-binding protein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. (377 aa)
potHPutrescine ABC transporter, permease protein PotH; Identified by match to protein family HMM PF00528. (317 aa)
potIPutrescine ABC transporter, permease protein PotI; Identified by match to protein family HMM PF00528. (281 aa)
macAMacrolide-specific efflux protein MacA; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01730; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (371 aa)
macBMacrolide-specific ABC-type efflux carrier protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (648 aa)
cudCABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC; Identified by match to protein family HMM PF00005; match to protein family HMM TIGR02868. (573 aa)
cydDABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM TIGR02857. (588 aa)
msbALipid A export permease/ATP-binding protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (582 aa)
csgFCurli production assembly/transport component CsgF. (138 aa)
ACD10509.1Curli production assembly/transport component CsgE. (40 aa)
potCSpermidine/putrescine ABC transporter, permease protein PotC; Identified by match to protein family HMM PF00528. (264 aa)
ACD09634.1ABC ATPase. (91 aa)
malFMaltose/maltodextrin ABC transporter, permease protein MalF; Identified by match to protein family HMM PF00528. (429 aa)
ACD08138.1ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (217 aa)
btuCVitamin B12 import system permease protein btuC; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane. (326 aa)
btuDVitamin B12 import ATP-binding protein BtuD; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system. (249 aa)
clcBChloride transporter, chloride channel (ClC) family; Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response; Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily. (418 aa)
sitB_2Iron/manganese transport system inner membrane protein SitB; Identified by match to protein family HMM PF00005. (275 aa)
sitC_2Iron/manganese transport system inner membrane protein SitC; Identified by match to protein family HMM PF00950; match to protein family HMM PF01032. (285 aa)
ACD06720.1Chelated iron transport system membrane protein yfeD; Identified by similarity to SP:Q56955; match to protein family HMM PF00950. (285 aa)
potASpermidine/putrescine ABC transporter, ATP-binding protein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (378 aa)
potBSpermidine/putrescine ABC transporter, permease protein PotB; Identified by match to protein family HMM PF00528. (287 aa)
mdtAMultidrug resistance protein MdtA; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01730; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (415 aa)
nuoMNADH-quinone oxidoreductase, M subunit; Identified by match to protein family HMM PF00361; match to protein family HMM TIGR01972. (509 aa)
znuCHigh-affinity zinc uptake ABC transporter, ATP-binding protein ZnuC; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. (251 aa)
ACD08623.1ABC transporter, quaternary amine uptake (QAT) family, ATP-binding protein; Identified by match to protein family HMM PF00005. (308 aa)
modFABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (490 aa)
kdpBK+-transporting ATPase, B subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (682 aa)
kdpAK+-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (557 aa)
metND-methionine ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (343 aa)
metID-methionine ABC transporter, permease protein; Identified by match to protein family HMM PF00528. (217 aa)
metQD-methionine ABC transporter, periplasmic D-methionine-binding lipoprotein; Identified by match to protein family HMM PF03180; match to protein family HMM TIGR00363; Belongs to the nlpA lipoprotein family. (271 aa)
fhuBFerrichrome ABC transporter, permease protein FhuB; Identified by match to protein family HMM PF01032; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (660 aa)
fhuCFerrichrome transport ATP-binding protein FhuC; Identified by match to protein family HMM PF00005. (265 aa)
ACD08116.1Putative permease; Identified by match to protein family HMM PF03739. (360 aa)
phnEPhosphonate ABC transporter, permease protein; Identified by match to protein family HMM PF00528; match to protein family HMM TIGR01097. (259 aa)
xylGD-xylose ABC transporter, ATP-binding protein; Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Xylose importer (TC 3.A.1.2.4) family. (513 aa)
ugpCSn-glycerol-3-phosphate transport ATP-binding protein; Part of the ABC transporter complex UgpABCE involved in sn- glycerol-3-phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. sn-glycerol-3- phosphate importer (TC 3.A.1.1.3) family. (356 aa)
ugpESn-glycerol 3-phosphate transport protein; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane. (281 aa)
ugpASn-glycerol-3-phosphate transport system permease protein UgpA; Identified by match to protein family HMM PF00528. (295 aa)
Your Current Organism:
Shigella boydii
NCBI taxonomy Id: 344609
Other names: S. boydii CDC 3083-94, Shigella boydii BS512, Shigella boydii CDC 3083-94, Shigella boydii str. CDC 3083-94, Shigella boydii strain CDC 3083-94
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