STRINGSTRING
mdlA mdlA thiQ thiQ ACD06361.1 ACD06361.1 fhuC fhuC metN metN tauB tauB lon lon dnaX dnaX ACD06765.1 ACD06765.1 ACD09260.1 ACD09260.1 fepC fepC gltL gltL modF modF modC modC ACD10211.1 ACD10211.1 ccmA ccmA ACD07448.1 ACD07448.1 mglA mglA ACD08623.1 ACD08623.1 znuC znuC ruvB ruvB araG araG yecC yecC potA potA dhaR dhaR oppD oppD oppF oppF sapF sapF sapD sapD pspF pspF tyrR tyrR sitB_2 sitB_2 hrpA hrpA ACD08966.1 ACD08966.1 ACD08157.1 ACD08157.1 ACD10372.1 ACD10372.1 sufC sufC btuD btuD ACD08138.1 ACD08138.1 lolD lolD uup uup msbA msbA ACD10168.1 ACD10168.1 cydD cydD cudC cudC clpA clpA macB macB artP artP potG potG gsiA gsiA ACD07573.1 ACD07573.1 glnQ glnQ ACD06569.1 ACD06569.1 hisP hisP cysA cysA ACD09202.1 ACD09202.1 clpB clpB recD recD norR norR recA recA proV proV ACD06319.1 ACD06319.1 ACD07459.1 ACD07459.1 ACD07543.1 ACD07543.1 lptB lptB ACD06852.1 ACD06852.1 hflB hflB ACD10495.1 ACD10495.1 ACD08303.1 ACD08303.1 rtcR rtcR ACD06351.1 ACD06351.1 nikE nikE nikD nikD ftsE ftsE livG livG livF livF ugpC ugpC xylG xylG dppD dppD dppF dppF rho rho ACD08392.1 ACD08392.1 ACD10382.1 ACD10382.1 atpD atpD pstB pstB dnaA dnaA ntrC ntrC hslU hslU zraR zraR dnaB dnaB dnaC dnaC radA radA ACD06493.1 ACD06493.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mdlAMultidrug resistance, ATP-binding protein mdlA; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664. (553 aa)
thiQThiamine ABC transporter, ATP-binding protein; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family. (232 aa)
ACD06361.1ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (308 aa)
fhuCFerrichrome transport ATP-binding protein FhuC; Identified by match to protein family HMM PF00005. (265 aa)
metND-methionine ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (343 aa)
tauBTaurine ABC transporter, ATP-binding protein; Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Taurine importer (TC 3.A.1.17.1) family. (255 aa)
lonATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, and UmuD. Its overproduction spec [...] (784 aa)
dnaXDNA polymerase III, tau subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (643 aa)
ACD06765.1ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (225 aa)
ACD09260.1ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (228 aa)
fepCFerric enterobactin ABC transporter, ATP-binding protein FepC; Identified by match to protein family HMM PF00005. (271 aa)
gltLGlutamate/aspartate ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (241 aa)
modFABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (490 aa)
modCMolybdate ABC transporter, ATP-binding protein; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. (352 aa)
ACD10211.1ABC transporter ATP-binding protein; Identified by similarity to SP:P33941; match to protein family HMM PF00005; match to protein family HMM TIGR01194. (547 aa)
ccmAHeme ABC exporter, ATP-binding protein CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (205 aa)
ACD07448.1ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005; Belongs to the ABC transporter superfamily. (529 aa)
mglAGalactoside ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (334 aa)
ACD08623.1ABC transporter, quaternary amine uptake (QAT) family, ATP-binding protein; Identified by match to protein family HMM PF00005. (308 aa)
znuCHigh-affinity zinc uptake ABC transporter, ATP-binding protein ZnuC; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. (251 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (336 aa)
araGL-arabinose ABC transporter, ATP-binding protein; Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Arabinose importer (TC 3.A.1.2.2) family. (504 aa)
yecCAmino acid ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (250 aa)
potASpermidine/putrescine ABC transporter, ATP-binding protein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (378 aa)
dhaRPTS-dependent dihydroxyacetone kinase operon regulatory protein, DhaR; Identified by match to protein family HMM PF00158; match to protein family HMM PF00989; match to protein family HMM PF01590; match to protein family HMM PF02954. (639 aa)
oppDOligopeptide ABC transporter, ATP-binding protein OppD; Identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; Belongs to the ABC transporter superfamily. (337 aa)
oppFOligopeptide ABC transporter, ATP-binding protein OppF; Identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; Belongs to the ABC transporter superfamily. (334 aa)
sapFPeptide ABC transporter, ATP-binding protein SapF; Identified by match to protein family HMM PF00005. (268 aa)
sapDPeptide ABC transporter, ATP-binding protein SapD; Identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; Belongs to the ABC transporter superfamily. (330 aa)
pspFSigma-54 dependent transcriptional regulator PspF; Identified by match to protein family HMM PF00158; match to protein family HMM PF02954; match to protein family HMM PF07728; match to protein family HMM TIGR02974. (325 aa)
tyrRTranscriptional regulatory protein TyrR; Identified by match to protein family HMM PF00158; match to protein family HMM PF01842. (513 aa)
sitB_2Iron/manganese transport system inner membrane protein SitB; Identified by match to protein family HMM PF00005. (275 aa)
hrpAATP-dependent helicase HrpA; Identified by match to protein family HMM PF00271; match to protein family HMM PF04408; match to protein family HMM PF07717; match to protein family HMM TIGR01967. (1300 aa)
ACD08966.1Putative ABC transport system ATP-binding protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; Belongs to the ABC transporter superfamily. (308 aa)
ACD08157.1ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; Belongs to the ABC transporter superfamily. (328 aa)
ACD10372.1Inner membrane ABC transporter ATP-binding protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF05992; match to protein family HMM PF06472. (561 aa)
sufCFeS assembly ATPase SufC; Identified by match to protein family HMM PF00005; match to protein family HMM TIGR01978. (248 aa)
btuDVitamin B12 import ATP-binding protein BtuD; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system. (249 aa)
ACD08138.1ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (217 aa)
lolDLipoprotein releasing system, ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (233 aa)
uupABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF02463. (635 aa)
msbALipid A export permease/ATP-binding protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (582 aa)
ACD10168.1Putative DNA recombination-associated ATPase RarA; Identified by match to protein family HMM PF00004. (447 aa)
cydDABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM TIGR02857. (588 aa)
cudCABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC; Identified by match to protein family HMM PF00005; match to protein family HMM TIGR02868. (573 aa)
clpAATP-dependent Clp protease ATP-binding subunit ClpA; Identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; match to protein family HMM TIGR02639; Belongs to the ClpA/ClpB family. (758 aa)
macBMacrolide-specific ABC-type efflux carrier protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (648 aa)
artPArginine ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (242 aa)
potGPutrescine ABC transporter, ATP-binding protein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. (377 aa)
gsiAGlutathione ABC transporter, ATP-binding protein GsiA; Identified by similarity to SP:P75796; match to protein family HMM PF00005; match to protein family HMM PF08352; Belongs to the ABC transporter superfamily. (623 aa)
ACD07573.1ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (530 aa)
glnQGlutamine ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (240 aa)
ACD06569.1ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (578 aa)
hisPHistidine ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (257 aa)
cysASulfate/thiosulfate ABC transporter, ATP-binding protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (365 aa)
ACD09202.1Sigma-54 dependent response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF07728. (444 aa)
clpBATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (857 aa)
recDExodeoxyribonuclease V, alpha subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...] (608 aa)
norRAnaerobic nitric oxide reductase transcription regulator NorR; Identified by match to protein family HMM PF00158; match to protein family HMM PF01590. (504 aa)
recAProtein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (353 aa)
proVGlycine betaine/L-proline ABC transporter, ATP binding protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00571; match to protein family HMM TIGR01186. (400 aa)
ACD06319.1ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (225 aa)
ACD07459.1ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (236 aa)
ACD07543.1Identified by match to protein family HMM PF00437; match to protein family HMM TIGR01420. (326 aa)
lptBLipopolysaccharide ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (241 aa)
ACD06852.1Toluene ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (269 aa)
hflBATP-dependent metallopeptidase HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (647 aa)
ACD10495.1Amino acid ABC transporter, ATP-binding protein; yhdZ; identified by match to protein family HMM PF00005. (252 aa)
ACD08303.1ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (637 aa)
rtcRSigma-54 dependent transcriptional regulator RtcR; Identified by match to protein family HMM PF00158; match to protein family HMM PF06956; match to protein family HMM PF07728. (532 aa)
ACD06351.1ABC transporter, ATP binding protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF01061. (911 aa)
nikENickel ABC transporter, ATP-binding protein NikE; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (268 aa)
nikDNickel ABC transporter, ATP-binding protein NikD; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (254 aa)
ftsECell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. (222 aa)
livGHigh-affinity branched-chain amino acid ABC transporter, ATP-binding protein LivG; Identified by match to protein family HMM PF00005. (255 aa)
livFHigh-affinity branched-chain amino acid ABC transporter, ATP-binding protein LivF; Identified by match to protein family HMM PF00005; Belongs to the ABC transporter superfamily. (241 aa)
ugpCSn-glycerol-3-phosphate transport ATP-binding protein; Part of the ABC transporter complex UgpABCE involved in sn- glycerol-3-phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. sn-glycerol-3- phosphate importer (TC 3.A.1.1.3) family. (356 aa)
xylGD-xylose ABC transporter, ATP-binding protein; Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Xylose importer (TC 3.A.1.2.4) family. (513 aa)
dppDDipeptide ABC transporter, ATP-binding protein DppD; Identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; Belongs to the ABC transporter superfamily. (327 aa)
dppFDipeptide ABC transporter, ATP-binding protein DppF; Identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; Belongs to the ABC transporter superfamily. (334 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (419 aa)
ACD08392.1ATPase, AAA family; Identified by match to protein family HMM PF01078; match to protein family HMM PF07728; match to protein family HMM TIGR00368. (506 aa)
ACD10382.1Hypothetical protein; Identified by glimmer; putative. (468 aa)
atpDATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (460 aa)
pstBPhosphate ABC transporter, ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (257 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (467 aa)
ntrCNitrogen regulation protein NR(I); Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (469 aa)
hslUHeat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (443 aa)
zraRResponse regulator ZraR; Identified by match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF02954; match to protein family HMM PF07728. (441 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (471 aa)
dnaCDNA replication protein DnaC. (245 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (460 aa)
ACD06493.1ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (555 aa)
Your Current Organism:
Shigella boydii
NCBI taxonomy Id: 344609
Other names: S. boydii CDC 3083-94, Shigella boydii BS512, Shigella boydii CDC 3083-94, Shigella boydii str. CDC 3083-94, Shigella boydii strain CDC 3083-94
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