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ACLA_002030 ACLA_002030 ACLA_069150 ACLA_069150 ACLA_070060 ACLA_070060 ACLA_070090 ACLA_070090 ACLA_070740 ACLA_070740 LSM1 LSM1 LSM4 LSM4 ACLA_074190 ACLA_074190 ACLA_075760 ACLA_075760 ACLA_076820 ACLA_076820 ACLA_054620 ACLA_054620 ACLA_010640 ACLA_010640 ACLA_012180 ACLA_012180 ACLA_012650 ACLA_012650 ACLA_013770 ACLA_013770 ACLA_014160 ACLA_014160 ACLA_015480 ACLA_015480 ACLA_016350 ACLA_016350 LSM5 LSM5 pan2 pan2 ACLA_092760 ACLA_092760 ACLA_066660 ACLA_066660 ACLA_051380 ACLA_051380 ccr4 ccr4 dhh1 dhh1 ACLA_035140 ACLA_035140 ACLA_038100 ACLA_038100 ACLA_040180 ACLA_040180 ACLA_077890 ACLA_077890 ACLA_078150 ACLA_078150 pan3 pan3 ACLA_021120 ACLA_021120 ACLA_023090 ACLA_023090 pab1 pab1 ACLA_030940 ACLA_030940 ACLA_032150 ACLA_032150 ACLA_032680 ACLA_032680 mrh4 mrh4 ACLA_083590 ACLA_083590
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACLA_0020305'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1408 aa)
ACLA_069150ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (368 aa)
ACLA_070060AMFR protein, putative. (195 aa)
ACLA_070090NOT2 family protein. (527 aa)
ACLA_070740Uncharacterized protein. (292 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation. (177 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (119 aa)
ACLA_074190U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (98 aa)
ACLA_075760Endonuclease/exonuclease/phosphatase family protein. (344 aa)
ACLA_076820Pyridoxamine 5'-phosphate oxidase. (224 aa)
ACLA_054620Uncharacterized protein. (297 aa)
ACLA_010640CCR4-NOT core complex subunit Caf1, putative. (507 aa)
ACLA_012180NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (260 aa)
ACLA_012650Decapping enzyme Dcp1, putative. (331 aa)
ACLA_013770Topisomerase II associated protein (Pat1), putative. (826 aa)
ACLA_014160Thiamin pyrophosphokinase-related protein. (322 aa)
ACLA_015480Decapping enzyme Dcp2, putative. (856 aa)
ACLA_016350YjeF_N domain protein. (705 aa)
LSM5U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (83 aa)
pan2PAN2-PAN3 deadenylation complex catalytic subunit pan2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1161 aa)
ACLA_092760CCR4-NOT transcription complex, subunit 3. (617 aa)
ACLA_066660RNA exonuclease, putative. (424 aa)
ACLA_051380Cell differentiation protein (Rcd1), putative. (406 aa)
ccr4Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to [...] (667 aa)
dhh1ATP-dependent RNA helicase dhh1; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (503 aa)
ACLA_035140DEAD/DEAH box RNA helicase, putative; Belongs to the DEAD box helicase family. (584 aa)
ACLA_038100Ccr4-Not transcription complex subunit (NOT1), putative. (2346 aa)
ACLA_040180RNA exonuclease Rex3, putative. (649 aa)
ACLA_077890Nudix hydrolase domain-containing protein. (192 aa)
ACLA_078150Uncharacterized protein. (557 aa)
pan3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...] (659 aa)
ACLA_021120Small nuclear ribonucleoprotein (LSM7), putative. (140 aa)
ACLA_023090G2/M phase checkpoint control protein Sum2, putative. (574 aa)
pab1Polyadenylate-binding protein, cytoplasmic and nuclear; Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and [...] (754 aa)
ACLA_030940Acid phosphatase, putative. (358 aa)
ACLA_032150ARS binding protein Abp2, putative. (785 aa)
ACLA_032680Thiamin pyrophosphokinase, putative. (342 aa)
mrh4ATP-dependent RNA helicase mrh4, mitochondrial; ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA (By similarity); Belongs to the DEAD box helicase family. MRH4 subfamily. (632 aa)
ACLA_083590CCR4-NOT core complex subunit Not4, putative. (1579 aa)
Your Current Organism:
Aspergillus clavatus
NCBI taxonomy Id: 344612
Other names: A. clavatus NRRL 1, Aspergillus clavatus NRRL 1
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