(23 nodes) Protein-lysine N-methyltransferase activity network (Aspergillus clavatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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Predicted Interactions

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Your Input:
	ACLA_071460	Uncharacterized protein. (818 aa)
	EFM7	Protein N-terminal and lysine N-methyltransferase EFM7; S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono-and dimethylation of 'Lys-3'. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family. (259 aa)
	ACLA_009270	SET and WW domain protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (968 aa)
	ACLA_011630	Uncharacterized protein. (326 aa)
	ACLA_015130	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (504 aa)
	ACLA_004200	SET domain protein. (426 aa)
	ACLA_069000	Uncharacterized protein. (355 aa)
	ACLA_069110	SET and MYND domain protein, putative. (555 aa)
	ACLA_088100	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. (1232 aa)
	EFM4	Protein-lysine N-methyltransferase EFM4; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family. (348 aa)
	EFM6	Protein-lysine N-methyltransferase EFM6; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha. Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily. (251 aa)
	ACLA_047260	Uncharacterized protein. (371 aa)
	ACLA_048940	Secretory component protein shr3, putative. (232 aa)
	ACLA_050140	SET domain protein. (677 aa)
	ACLA_034350	SET domain-containing protein. (421 aa)
	ACLA_096150	Ribosomal lysine N-methyltransferase 4; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that monomethylates 60S ribosomal protein L42. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (492 aa)
	ACLA_019250	Glucose-inducible SAM-dependent methyltransferase Rrg1, putative. (345 aa)
	ACLA_020730	WD domain protein. (481 aa)
	ACLA_021910	SET domain protein. (498 aa)
	ACLA_022270	Copper-activated transcription factor GRISEA, putative. (430 aa)
	ACLA_080330	SET domain protein. (635 aa)
	ACLA_034430	Histone-lysine N-methyltransferase (Ash1), putative. (847 aa)
	ACLA_039900	PHD transcription factor, putative. (862 aa)

Your Current Organism:

Aspergillus clavatus

NCBI taxonomy Id: 344612
Other names: A. clavatus NRRL 1, Aspergillus clavatus NRRL 1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLA_009270	ACLA_011630	A1C9T9	A1CAG8	SET and WW domain protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	Uncharacterized protein.	0.590
ACLA_009270	ACLA_015130	A1C9T9	A1CBF7	SET and WW domain protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	0.965
ACLA_009270	ACLA_020730	A1C9T9	A1CNZ5	SET and WW domain protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	WD domain protein.	0.736
ACLA_009270	ACLA_034430	A1C9T9	A1CJB6	SET and WW domain protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	Histone-lysine N-methyltransferase (Ash1), putative.	0.977
ACLA_009270	ACLA_039900	A1C9T9	A1CKV0	SET and WW domain protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	PHD transcription factor, putative.	0.444
ACLA_009270	ACLA_050140	A1C9T9	A1CI37	SET and WW domain protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	SET domain protein.	0.454
ACLA_009270	ACLA_069110	A1C9T9	A1C662	SET and WW domain protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	SET and MYND domain protein, putative.	0.925
ACLA_009270	ACLA_071460	A1C9T9	A1C6U2	SET and WW domain protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	Uncharacterized protein.	0.604
ACLA_009270	ACLA_080330	A1C9T9	A1CSR2	SET and WW domain protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	SET domain protein.	0.961
ACLA_009270	ACLA_088100	A1C9T9	A1CE22	SET and WW domain protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.	0.974
ACLA_011630	ACLA_009270	A1CAG8	A1C9T9	Uncharacterized protein.	SET and WW domain protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	0.590
ACLA_011630	ACLA_020730	A1CAG8	A1CNZ5	Uncharacterized protein.	WD domain protein.	0.515
ACLA_011630	ACLA_088100	A1CAG8	A1CE22	Uncharacterized protein.	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.	0.728
ACLA_015130	ACLA_009270	A1CBF7	A1C9T9	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	SET and WW domain protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	0.965
ACLA_015130	ACLA_034430	A1CBF7	A1CJB6	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	Histone-lysine N-methyltransferase (Ash1), putative.	0.941
ACLA_015130	ACLA_069110	A1CBF7	A1C662	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	SET and MYND domain protein, putative.	0.929
ACLA_015130	ACLA_071460	A1CBF7	A1C6U2	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	Uncharacterized protein.	0.559
ACLA_015130	ACLA_080330	A1CBF7	A1CSR2	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	SET domain protein.	0.958
ACLA_015130	ACLA_088100	A1CBF7	A1CE22	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.	0.983
ACLA_019250	ACLA_069000	A1CNJ9	A1C651	Glucose-inducible SAM-dependent methyltransferase Rrg1, putative.	Uncharacterized protein.	0.422