(25 nodes) mRNA 3-end processing network (Aspergillus clavatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ACLA_068240	Uncharacterized protein. (113 aa)
	ACLA_068230	Heterogeneous nuclear ribonucleoprotein HRP1. (466 aa)
	ACLA_068090	Retinoblastoma-binding protein. (631 aa)
	ACLA_003240	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (278 aa)
	ACLA_000920	RNA binding protein Nrd1, putative. (741 aa)
	ACLA_070150	Pol II transcription elongation factor subunit Cdc73, putative. (482 aa)
	ACLA_010440	Nucleoside-diphosphate-sugar epimerase, putative. (2450 aa)
	clp1	mRNA cleavage and polyadenylation factor clp1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation. (560 aa)
	ACLA_015430	WD repeat protein. (371 aa)
	ACLA_005400	Serine/threonine protein kinase (Kin28), putative; Belongs to the protein kinase superfamily. (404 aa)
	ACLA_092960	RNA polymerase II transcription elongation factor Rtf1p, putative. (605 aa)
	ACLA_049250	DUF618 domain protein. (416 aa)
	ACLA_035980	Polymerase (RNA) II (DNA directed) polypeptide D. (148 aa)
	ACLA_037490	Cleavage and polyadenylation specificity factor subunit 2. (1014 aa)
	ACLA_057780	DUF3453 domain-containing protein. (764 aa)
	ACLA_038940	CFIA complex component Rna14, putative. (1058 aa)
	sub2	ATP-dependent RNA helicase sub2; ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity); Belongs to the DEAD box helicase family. DECD subfamily. (441 aa)
	ACLA_018680	Cleavage and polyadenylation specifity factor, 73 kDa subunit, putative. (878 aa)
	ACLA_019990	Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (598 aa)
	ACLA_027100	mRNA cleavage factor complex component Pcf11, putative. (652 aa)
	ACLA_029690	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (324 aa)
	ACLA_031620	mRNA cleavage and polyadenylation specificity factor complex subunit, putative. (255 aa)
	ACLA_080220	WD repeat protein. (615 aa)
	ACLA_080910	Polyadenylation factor subunit CstF64, putative. (296 aa)
	ACLA_084420	Cleavage and polyadenylylation specificity factor subunit Fip1, putative. (320 aa)

Your Current Organism:

Aspergillus clavatus

NCBI taxonomy Id: 344612
Other names: A. clavatus NRRL 1, Aspergillus clavatus NRRL 1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLA_000920	ACLA_027100	A1C4R3	A1CQR7	RNA binding protein Nrd1, putative.	mRNA cleavage factor complex component Pcf11, putative.	0.695
ACLA_000920	ACLA_038940	A1C4R3	A1CKK5	RNA binding protein Nrd1, putative.	CFIA complex component Rna14, putative.	0.509
ACLA_000920	ACLA_049250	A1C4R3	A1CHU8	RNA binding protein Nrd1, putative.	DUF618 domain protein.	0.617
ACLA_000920	ACLA_080220	A1C4R3	A1CSQ1	RNA binding protein Nrd1, putative.	WD repeat protein.	0.451
ACLA_003240	ACLA_018680	A1C5E4	A1CNE3	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Cleavage and polyadenylation specifity factor, 73 kDa subunit, putative.	0.924
ACLA_003240	ACLA_019990	A1C5E4	A1CNS3	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's.	0.911
ACLA_003240	ACLA_027100	A1C5E4	A1CQR7	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	mRNA cleavage factor complex component Pcf11, putative.	0.926
ACLA_003240	ACLA_029690	A1C5E4	A1CRG8	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.414
ACLA_003240	ACLA_031620	A1C5E4	A1CS08	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	mRNA cleavage and polyadenylation specificity factor complex subunit, putative.	0.994
ACLA_003240	ACLA_037490	A1C5E4	A1CK68	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Cleavage and polyadenylation specificity factor subunit 2.	0.927
ACLA_003240	ACLA_038940	A1C5E4	A1CKK5	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	CFIA complex component Rna14, putative.	0.870
ACLA_003240	ACLA_057780	A1C5E4	A1C3Y2	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	DUF3453 domain-containing protein.	0.852
ACLA_003240	ACLA_080220	A1C5E4	A1CSQ1	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	WD repeat protein.	0.895
ACLA_003240	ACLA_080910	A1C5E4	A1CSX0	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Polyadenylation factor subunit CstF64, putative.	0.886
ACLA_003240	ACLA_084420	A1C5E4	A1CTW0	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Cleavage and polyadenylylation specificity factor subunit Fip1, putative.	0.977
ACLA_003240	clp1	A1C5E4	A1CB93	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	mRNA cleavage and polyadenylation factor clp1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	0.864
ACLA_003240	sub2	A1C5E4	A1CMQ7	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	ATP-dependent RNA helicase sub2; ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity); Belongs to the DEAD box helicase family. DECD subfamily.	0.718
ACLA_005400	ACLA_027100	A1CD59	A1CQR7	Serine/threonine protein kinase (Kin28), putative; Belongs to the protein kinase superfamily.	mRNA cleavage factor complex component Pcf11, putative.	0.706
ACLA_005400	ACLA_035980	A1CD59	A1CJS1	Serine/threonine protein kinase (Kin28), putative; Belongs to the protein kinase superfamily.	Polymerase (RNA) II (DNA directed) polypeptide D.	0.954
ACLA_015430	ACLA_018680	A1CBI3	A1CNE3	WD repeat protein.	Cleavage and polyadenylation specifity factor, 73 kDa subunit, putative.	0.995