(16 nodes) Regulation of transcription elongation from RNA polymerase II promoter network (Aspergillus clavatus)

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Your Input:
	ACLA_001990	Protein kinase, putative. (1072 aa)
	ACLA_024780	Prefoldin subunit 5, putative. (173 aa)
	ACLA_026290	Uncharacterized protein. (468 aa)
	ccr4	Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to [...] (667 aa)
	ACLA_051380	Cell differentiation protein (Rcd1), putative. (406 aa)
	ACLA_046550	Helicase C-terminal domain protein. (432 aa)
	ACLA_092960	RNA polymerase II transcription elongation factor Rtf1p, putative. (605 aa)
	ACLA_088560	Proteasome regulatory particle subunit Rpt4, putative; Belongs to the AAA ATPase family. (393 aa)
	ACLA_005400	Serine/threonine protein kinase (Kin28), putative; Belongs to the protein kinase superfamily. (404 aa)
	ACLA_060570	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (717 aa)
	ACLA_010010	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. (120 aa)
	ACLA_008810	Protein kinase domain protein. (552 aa)
	ACLA_053690	Proteasome regulatory particle subunit Rpt6, putative; Belongs to the AAA ATPase family. (389 aa)
	ACLA_070150	Pol II transcription elongation factor subunit Cdc73, putative. (482 aa)
	ACLA_033860	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family. (1421 aa)
	ACLA_052110	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (767 aa)

Your Current Organism:

Aspergillus clavatus

NCBI taxonomy Id: 344612
Other names: A. clavatus NRRL 1, Aspergillus clavatus NRRL 1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLA_001990	ACLA_005400	A1C520	A1CD59	Protein kinase, putative.	Serine/threonine protein kinase (Kin28), putative; Belongs to the protein kinase superfamily.	0.756
ACLA_001990	ACLA_008810	A1C520	A1C9P3	Protein kinase, putative.	Protein kinase domain protein.	0.496
ACLA_001990	ACLA_010010	A1C520	A1CA10	Protein kinase, putative.	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.755
ACLA_001990	ACLA_026290	A1C520	A1CQJ1	Protein kinase, putative.	Uncharacterized protein.	0.463
ACLA_001990	ACLA_033860	A1C520	A1CJ59	Protein kinase, putative.	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family.	0.463
ACLA_001990	ACLA_052110	A1C520	A1CIN4	Protein kinase, putative.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.462
ACLA_001990	ACLA_070150	A1C520	A1C6G3	Protein kinase, putative.	Pol II transcription elongation factor subunit Cdc73, putative.	0.505
ACLA_005400	ACLA_001990	A1CD59	A1C520	Serine/threonine protein kinase (Kin28), putative; Belongs to the protein kinase superfamily.	Protein kinase, putative.	0.756
ACLA_005400	ACLA_008810	A1CD59	A1C9P3	Serine/threonine protein kinase (Kin28), putative; Belongs to the protein kinase superfamily.	Protein kinase domain protein.	0.749
ACLA_005400	ACLA_010010	A1CD59	A1CA10	Serine/threonine protein kinase (Kin28), putative; Belongs to the protein kinase superfamily.	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.926
ACLA_005400	ACLA_052110	A1CD59	A1CIN4	Serine/threonine protein kinase (Kin28), putative; Belongs to the protein kinase superfamily.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.594
ACLA_005400	ACLA_060570	A1CD59	A1CC45	Serine/threonine protein kinase (Kin28), putative; Belongs to the protein kinase superfamily.	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	0.908
ACLA_008810	ACLA_001990	A1C9P3	A1C520	Protein kinase domain protein.	Protein kinase, putative.	0.496
ACLA_008810	ACLA_005400	A1C9P3	A1CD59	Protein kinase domain protein.	Serine/threonine protein kinase (Kin28), putative; Belongs to the protein kinase superfamily.	0.749
ACLA_008810	ACLA_010010	A1C9P3	A1CA10	Protein kinase domain protein.	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.787
ACLA_008810	ACLA_026290	A1C9P3	A1CQJ1	Protein kinase domain protein.	Uncharacterized protein.	0.452
ACLA_008810	ACLA_033860	A1C9P3	A1CJ59	Protein kinase domain protein.	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family.	0.507
ACLA_008810	ACLA_052110	A1C9P3	A1CIN4	Protein kinase domain protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.462
ACLA_008810	ACLA_070150	A1C9P3	A1C6G3	Protein kinase domain protein.	Pol II transcription elongation factor subunit Cdc73, putative.	0.514
ACLA_010010	ACLA_001990	A1CA10	A1C520	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	Protein kinase, putative.	0.755