(45 nodes) mRNA cis splicing, via spliceosome network (Aspergillus clavatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ACLA_002730	Splicing factor 3a subunit 3, putative. (504 aa)
	ACLA_085900	Sde2_N_Ubi domain-containing protein. (309 aa)
	ACLA_085840	Uncharacterized protein. (299 aa)
	ACLA_084730	DnaJ domain protein. (214 aa)
	ACLA_084410	XAP5 domain protein. (366 aa)
	ACLA_083720	DUF572 domain protein. (371 aa)
	ACLA_083430	FF domain protein. (576 aa)
	ACLA_082970	Tudor domain-containing protein. (312 aa)
	ACLA_080710	Cwf15/Cwc15 cell cycle control family protein. (239 aa)
	ACLA_080580	DUF2040 domain-containing protein. (456 aa)
	ACLA_080400	Nuclear cap-binding protein subunit 2. (138 aa)
	ACLA_079420	Pre-mRNA splicing factor (Srp1), putative. (217 aa)
	ACLA_030050	Uncharacterized protein. (276 aa)
	ACLA_028120	Uncharacterized protein. (216 aa)
	ACLA_026120	Uncharacterized protein. (202 aa)
	ACLA_025340	Cell cycle control protein (Cwf4), putative. (676 aa)
	ACLA_024550	Mago nashi domain protein. (110 aa)
	ACLA_024480	DUF1604 domain protein. (873 aa)
	ACLA_019550	RNA splicing factor (Pad-1), putative. (566 aa)
	ACLA_097830	Uncharacterized protein. (291 aa)
	ACLA_041070	Uncharacterized protein. (187 aa)
	ACLA_038420	Serine/threonine protein kinase (Prp4), putative. (800 aa)
	ACLA_038350	CID domain-containing protein. (818 aa)
	ACLA_037300	Regulatory factor Sgt1, putative. (611 aa)
	ACLA_035490	Rna-binding protein. (726 aa)
	ACLA_034390	Pre-mRNA splicing factor, putative. (528 aa)
	ACLA_052350	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (218 aa)
	ACLA_050870	Cell cycle control protein (Cwf19), putative. (706 aa)
	ACLA_049620	DNA binding protein SART-1, putative. (668 aa)
	ACLA_048370	DEAD/DEAH box helicase, putative. (590 aa)
	ACLA_046120	G-patch DNA repair protein (Drt111), putative. (516 aa)
	ACLA_045670	SMN domain-containing protein. (165 aa)
	ACLA_065640	DUF1716 domain protein. (585 aa)
	ACLA_065250	U5 snRNP complex subunit, putative. (359 aa)
	ACLA_091810	Pre-mRNA splicing factor (Prp8), putative. (2354 aa)
	ACLA_091780	Cactin, putative. (559 aa)
	ACLA_091280	RNA binding protein (Rbm8A), putative. (159 aa)
	ACLA_010070	Cell cycle control protein (Cwf2), putative. (418 aa)
	ACLA_009110	Uncharacterized protein. (479 aa)
	ACLA_054030	Pre-mRNA-splicing factor; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. (1421 aa)
	ACLA_053550	Uncharacterized protein. (171 aa)
	ACLA_075850	Pinin/SDK/memA domain protein. (313 aa)
	ACLA_071040	Uncharacterized protein. (416 aa)
	ACLA_068880	Uncharacterized protein. (760 aa)
	ACLA_002080	WD domain protein. (334 aa)

Your Current Organism:

Aspergillus clavatus

NCBI taxonomy Id: 344612
Other names: A. clavatus NRRL 1, Aspergillus clavatus NRRL 1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLA_002080	ACLA_019550	A1C529	A1CNM9	WD domain protein.	RNA splicing factor (Pad-1), putative.	0.444
ACLA_002080	ACLA_024480	A1C529	A1CQ12	WD domain protein.	DUF1604 domain protein.	0.880
ACLA_002080	ACLA_026120	A1C529	A1CQH4	WD domain protein.	Uncharacterized protein.	0.510
ACLA_002080	ACLA_050870	A1C529	A1CIB0	WD domain protein.	Cell cycle control protein (Cwf19), putative.	0.450
ACLA_002080	ACLA_054030	A1C529	A1C933	WD domain protein.	Pre-mRNA-splicing factor; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.	0.425
ACLA_002080	ACLA_091810	A1C529	A1CF34	WD domain protein.	Pre-mRNA splicing factor (Prp8), putative.	0.940
ACLA_002730	ACLA_010070	A1C594	A1CA16	Splicing factor 3a subunit 3, putative.	Cell cycle control protein (Cwf2), putative.	0.677
ACLA_002730	ACLA_025340	A1C594	A1CQ96	Splicing factor 3a subunit 3, putative.	Cell cycle control protein (Cwf4), putative.	0.914
ACLA_002730	ACLA_028120	A1C594	A1CR16	Splicing factor 3a subunit 3, putative.	Uncharacterized protein.	0.512
ACLA_002730	ACLA_034390	A1C594	A1CJB2	Splicing factor 3a subunit 3, putative.	Pre-mRNA splicing factor, putative.	0.999
ACLA_002730	ACLA_038350	A1C594	A1CKF0	Splicing factor 3a subunit 3, putative.	CID domain-containing protein.	0.773
ACLA_002730	ACLA_038420	A1C594	A1CKF7	Splicing factor 3a subunit 3, putative.	Serine/threonine protein kinase (Prp4), putative.	0.470
ACLA_002730	ACLA_041070	A1C594	A1CL67	Splicing factor 3a subunit 3, putative.	Uncharacterized protein.	0.460
ACLA_002730	ACLA_046120	A1C594	A1CGZ2	Splicing factor 3a subunit 3, putative.	G-patch DNA repair protein (Drt111), putative.	0.859
ACLA_002730	ACLA_048370	A1C594	A1CHL2	Splicing factor 3a subunit 3, putative.	DEAD/DEAH box helicase, putative.	0.477
ACLA_002730	ACLA_049620	A1C594	A1CHY5	Splicing factor 3a subunit 3, putative.	DNA binding protein SART-1, putative.	0.989
ACLA_002730	ACLA_052350	A1C594	A1CIQ7	Splicing factor 3a subunit 3, putative.	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.	0.939
ACLA_002730	ACLA_054030	A1C594	A1C933	Splicing factor 3a subunit 3, putative.	Pre-mRNA-splicing factor; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.	0.499
ACLA_002730	ACLA_065250	A1C594	A1CG11	Splicing factor 3a subunit 3, putative.	U5 snRNP complex subunit, putative.	0.566
ACLA_002730	ACLA_065640	A1C594	A1CG50	Splicing factor 3a subunit 3, putative.	DUF1716 domain protein.	0.680