14 items (Strongyloides ratti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A090LB94	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (294 aa)
	A0A090L753	XPG-I domain and 5'-3' exonuclease, C-terminal domain-containing protein. (501 aa)
	A0A090L1U9	Endonuclease. (162 aa)
	A0A090KXX7	DNA repair endonuclease XPF. (866 aa)
	A0A090L9A7	Double-strand break repair protein MRE11A; Belongs to the MRE11/RAD32 family. (541 aa)
	A0A090LA41	Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. (1819 aa)
	A0A090LDS3	DNA replication ATP-dependent helicase/nuclease DNA2. (1032 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (366 aa)
	A0A090LG13	annotation not available (437 aa)
	A0A090LIP5	Endonuclease. (266 aa)
	A0A090LKQ0	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (664 aa)
	A0A090MY01	Crossover junction endonuclease MUS81. (462 aa)
	A0A090MYW4	Exonuclease 1. (530 aa)
	A0A090L8M4	Uncharacterized protein. (427 aa)

Your Current Organism:

Strongyloides ratti

NCBI taxonomy Id: 34506
Other names: S. ratti

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A090KXX7	A0A090L753	A0A090KXX7	A0A090L753	DNA repair endonuclease XPF.	XPG-I domain and 5'-3' exonuclease, C-terminal domain-containing protein.	0.949
A0A090KXX7	A0A090L9A7	A0A090KXX7	A0A090L9A7	DNA repair endonuclease XPF.	Double-strand break repair protein MRE11A; Belongs to the MRE11/RAD32 family.	0.851
A0A090KXX7	A0A090LB94	A0A090KXX7	A0A090LB94	DNA repair endonuclease XPF.	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family.	0.930
A0A090KXX7	A0A090LDS3	A0A090KXX7	A0A090LDS3	DNA repair endonuclease XPF.	DNA replication ATP-dependent helicase/nuclease DNA2.	0.822
A0A090KXX7	A0A090LKQ0	A0A090KXX7	A0A090LKQ0	DNA repair endonuclease XPF.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.849
A0A090KXX7	A0A090MY01	A0A090KXX7	A0A090MY01	DNA repair endonuclease XPF.	Crossover junction endonuclease MUS81.	0.968
A0A090KXX7	A0A090MYW4	A0A090KXX7	A0A090MYW4	DNA repair endonuclease XPF.	Exonuclease 1.	0.897
A0A090KXX7	FEN1	A0A090KXX7	A0A090LE32	DNA repair endonuclease XPF.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.890
A0A090L1U9	A0A090L753	A0A090L1U9	A0A090L753	Endonuclease.	XPG-I domain and 5'-3' exonuclease, C-terminal domain-containing protein.	0.448
A0A090L1U9	A0A090MYW4	A0A090L1U9	A0A090MYW4	Endonuclease.	Exonuclease 1.	0.461
A0A090L1U9	FEN1	A0A090L1U9	A0A090LE32	Endonuclease.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.735
A0A090L753	A0A090KXX7	A0A090L753	A0A090KXX7	XPG-I domain and 5'-3' exonuclease, C-terminal domain-containing protein.	DNA repair endonuclease XPF.	0.949
A0A090L753	A0A090L1U9	A0A090L753	A0A090L1U9	XPG-I domain and 5'-3' exonuclease, C-terminal domain-containing protein.	Endonuclease.	0.448
A0A090L753	A0A090L9A7	A0A090L753	A0A090L9A7	XPG-I domain and 5'-3' exonuclease, C-terminal domain-containing protein.	Double-strand break repair protein MRE11A; Belongs to the MRE11/RAD32 family.	0.918
A0A090L753	A0A090LB94	A0A090L753	A0A090LB94	XPG-I domain and 5'-3' exonuclease, C-terminal domain-containing protein.	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family.	0.770
A0A090L753	A0A090LDS3	A0A090L753	A0A090LDS3	XPG-I domain and 5'-3' exonuclease, C-terminal domain-containing protein.	DNA replication ATP-dependent helicase/nuclease DNA2.	0.912
A0A090L753	A0A090LIP5	A0A090L753	A0A090LIP5	XPG-I domain and 5'-3' exonuclease, C-terminal domain-containing protein.	Endonuclease.	0.448
A0A090L753	A0A090MY01	A0A090L753	A0A090MY01	XPG-I domain and 5'-3' exonuclease, C-terminal domain-containing protein.	Crossover junction endonuclease MUS81.	0.959
A0A090L753	A0A090MYW4	A0A090L753	A0A090MYW4	XPG-I domain and 5'-3' exonuclease, C-terminal domain-containing protein.	Exonuclease 1.	0.523
A0A090L753	FEN1	A0A090L753	A0A090LE32	XPG-I domain and 5'-3' exonuclease, C-terminal domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.653