(36 nodes) Cellular response to toxic substance network (Strongyloides ratti)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A090LLP9	Peroxidasin-like protein. (1534 aa)
	A0A090MZC3	Uncharacterized protein; Belongs to the GST superfamily. (353 aa)
	A0A090MY64	DUF953 domain-containing protein. (128 aa)
	A0A090MXK1	Glutathione S-transferase kappa. (225 aa)
	A0A090MWB2	15 kDa selenoprotein. (159 aa)
	A0A090MVU8	UNC93-like protein MFSD11. (438 aa)
	A0A090MTV8	Peroxiredoxin-6. (231 aa)
	A0A090LST9	MIP04163p. (615 aa)
	A0A090LND6	Uncharacterized protein. (408 aa)
	A0A090LMY1	Immunoglobulin-like fold domain-containing protein. (624 aa)
	A0A090LLX6	Peroxidasin-like protein. (1419 aa)
	A0A090LLL5	Superoxide dismutase [Cu-Zn]. (175 aa)
	A0A090LKX0	Uncharacterized protein. (341 aa)
	A0A090LKN0	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (190 aa)
	A0A090LJT3	Prostaglandin E synthase 2. (343 aa)
	A0A090LI74	UNC93-like protein MFSD11. (459 aa)
	A0A090LGD1	annotation not available (400 aa)
	A0A090LGB1	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (278 aa)
	A0A090LEW3	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (505 aa)
	A0A090LE94	Dual oxidase 1. (1518 aa)
	A0A090LE48	MIF4-like, type 1/2/3 domain and Armadillo-type fold domain-containing protein. (280 aa)
	A0A090LCK6	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (132 aa)
	A0A090LC50	Glutaredoxin-1. (116 aa)
	A0A090LBQ0	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (158 aa)
	A0A090LAG7	Thioredoxin-like protein 1. (303 aa)
	A0A090L7Z9	Nucleoredoxin. (528 aa)
	A0A090L610	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (381 aa)
	A0A090L545	Redox-regulatory protein FAM213A. (446 aa)
	A0A090L504	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (218 aa)
	A0A090L4X9	Peroxidasin-like protein. (970 aa)
	A0A090L430	Extracellular superoxide dismutase [Cu-Zn]. (193 aa)
	A0A090L0T6	UNC93-like protein MFSD11. (453 aa)
	A0A090L0E0	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (468 aa)
	A0A090L067	annotation not available (223 aa)
	A0A090L053	annotation not available (207 aa)
	A0A090KXI3	Thioredoxin reductase 1, cytoplasmic; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (678 aa)

Your Current Organism:

Strongyloides ratti

NCBI taxonomy Id: 34506
Other names: S. ratti

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A090KXI3	A0A090L053	Thioredoxin reductase 1, cytoplasmic; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	annotation not available	0.649
A0A090KXI3	A0A090L067	Thioredoxin reductase 1, cytoplasmic; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	annotation not available	0.649
A0A090KXI3	A0A090L504	Thioredoxin reductase 1, cytoplasmic; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.412
A0A090KXI3	A0A090LC50	Thioredoxin reductase 1, cytoplasmic; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Glutaredoxin-1.	0.739
A0A090KXI3	A0A090LEW3	Thioredoxin reductase 1, cytoplasmic; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.545
A0A090KXI3	A0A090LKN0	Thioredoxin reductase 1, cytoplasmic; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.722
A0A090KXI3	A0A090LKX0	Thioredoxin reductase 1, cytoplasmic; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Uncharacterized protein.	0.566
A0A090KXI3	A0A090LND6	Thioredoxin reductase 1, cytoplasmic; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Uncharacterized protein.	0.722
A0A090KXI3	A0A090MTV8	Thioredoxin reductase 1, cytoplasmic; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Peroxiredoxin-6.	0.588
A0A090KXI3	A0A090MWB2	Thioredoxin reductase 1, cytoplasmic; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	15 kDa selenoprotein.	0.489
A0A090KXI3	A0A090MZC3	Thioredoxin reductase 1, cytoplasmic; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Uncharacterized protein; Belongs to the GST superfamily.	0.736
A0A090L053	A0A090KXI3	annotation not available	Thioredoxin reductase 1, cytoplasmic; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.649
A0A090L053	A0A090L0E0	annotation not available	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.699
A0A090L053	A0A090L430	annotation not available	Extracellular superoxide dismutase [Cu-Zn].	0.624
A0A090L053	A0A090L504	annotation not available	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.738
A0A090L053	A0A090LAG7	annotation not available	Thioredoxin-like protein 1.	0.410
A0A090L053	A0A090LBQ0	annotation not available	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.665
A0A090L053	A0A090LC50	annotation not available	Glutaredoxin-1.	0.444
A0A090L053	A0A090LEW3	annotation not available	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.784
A0A090L053	A0A090LKN0	annotation not available	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.807