13 items (Strongyloides ratti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A090KXX7	DNA repair endonuclease XPF. (866 aa)
	A0A090L1A0	Mismatch repair endonuclease PMS2. (718 aa)
	A0A090L1U9	Endonuclease. (162 aa)
	A0A090L3L3	tRNA-splicing endonuclease subunit Sen2. (224 aa)
	A0A090L9A7	Double-strand break repair protein MRE11A; Belongs to the MRE11/RAD32 family. (541 aa)
	A0A090LB94	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (294 aa)
	A0A090LCP3	Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (386 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (366 aa)
	A0A090LE72	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (290 aa)
	A0A090LIP5	Endonuclease. (266 aa)
	NTH1	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (286 aa)
	A0A090LLK7	annotation not available (413 aa)
	A0A090MY01	Crossover junction endonuclease MUS81. (462 aa)

Your Current Organism:

Strongyloides ratti

NCBI taxonomy Id: 34506
Other names: S. ratti

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A090KXX7	A0A090L1A0	A0A090KXX7	A0A090L1A0	DNA repair endonuclease XPF.	Mismatch repair endonuclease PMS2.	0.408
A0A090KXX7	A0A090L9A7	A0A090KXX7	A0A090L9A7	DNA repair endonuclease XPF.	Double-strand break repair protein MRE11A; Belongs to the MRE11/RAD32 family.	0.851
A0A090KXX7	A0A090LB94	A0A090KXX7	A0A090LB94	DNA repair endonuclease XPF.	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family.	0.930
A0A090KXX7	A0A090LE72	A0A090KXX7	A0A090LE72	DNA repair endonuclease XPF.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.526
A0A090KXX7	A0A090MY01	A0A090KXX7	A0A090MY01	DNA repair endonuclease XPF.	Crossover junction endonuclease MUS81.	0.968
A0A090KXX7	FEN1	A0A090KXX7	A0A090LE32	DNA repair endonuclease XPF.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.890
A0A090KXX7	NTH1	A0A090KXX7	A0A090LJL0	DNA repair endonuclease XPF.	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.727
A0A090L1A0	A0A090KXX7	A0A090L1A0	A0A090KXX7	Mismatch repair endonuclease PMS2.	DNA repair endonuclease XPF.	0.408
A0A090L1A0	A0A090L9A7	A0A090L1A0	A0A090L9A7	Mismatch repair endonuclease PMS2.	Double-strand break repair protein MRE11A; Belongs to the MRE11/RAD32 family.	0.486
A0A090L1A0	A0A090MY01	A0A090L1A0	A0A090MY01	Mismatch repair endonuclease PMS2.	Crossover junction endonuclease MUS81.	0.573
A0A090L1A0	FEN1	A0A090L1A0	A0A090LE32	Mismatch repair endonuclease PMS2.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.860
A0A090L1A0	NTH1	A0A090L1A0	A0A090LJL0	Mismatch repair endonuclease PMS2.	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.550
A0A090L1U9	FEN1	A0A090L1U9	A0A090LE32	Endonuclease.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.735
A0A090L9A7	A0A090KXX7	A0A090L9A7	A0A090KXX7	Double-strand break repair protein MRE11A; Belongs to the MRE11/RAD32 family.	DNA repair endonuclease XPF.	0.851
A0A090L9A7	A0A090L1A0	A0A090L9A7	A0A090L1A0	Double-strand break repair protein MRE11A; Belongs to the MRE11/RAD32 family.	Mismatch repair endonuclease PMS2.	0.486
A0A090L9A7	A0A090LB94	A0A090L9A7	A0A090LB94	Double-strand break repair protein MRE11A; Belongs to the MRE11/RAD32 family.	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family.	0.585
A0A090L9A7	A0A090MY01	A0A090L9A7	A0A090MY01	Double-strand break repair protein MRE11A; Belongs to the MRE11/RAD32 family.	Crossover junction endonuclease MUS81.	0.845
A0A090L9A7	FEN1	A0A090L9A7	A0A090LE32	Double-strand break repair protein MRE11A; Belongs to the MRE11/RAD32 family.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.983
A0A090L9A7	NTH1	A0A090L9A7	A0A090LJL0	Double-strand break repair protein MRE11A; Belongs to the MRE11/RAD32 family.	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.509
A0A090LB94	A0A090KXX7	A0A090LB94	A0A090KXX7	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family.	DNA repair endonuclease XPF.	0.930