STRINGSTRING
AJE02495.1 AJE02495.1 AJE02654.1 AJE02654.1 AJE04710.1 AJE04710.1 mqnE mqnE mqnC mqnC AJE04563.1 AJE04563.1 lipA lipA thiE-2 thiE-2 thiG thiG thiE thiE AJE04150.1 AJE04150.1 AJE04919.1 AJE04919.1 aksA aksA AJE03953.1 AJE03953.1 trpC trpC trpF trpF trpA trpA AJE03867.1 AJE03867.1 AJE03861.1 AJE03861.1 rlmN rlmN AJE03774.1 AJE03774.1 AJE03748.1 AJE03748.1 AJE03740.1 AJE03740.1 AJE03738.1 AJE03738.1 guaB guaB AJE04888.1 AJE04888.1 AJE03628.1 AJE03628.1 AJE03622.1 AJE03622.1 AJE03611.1 AJE03611.1 AJE03545.1 AJE03545.1 AJE03496.1 AJE03496.1 AJE03461.1 AJE03461.1 pyrF pyrF tpiA tpiA pyrD pyrD AJE03359.1 AJE03359.1 queE queE bioB bioB AJE03158.1 AJE03158.1 AJE04731.1 AJE04731.1 pdxJ pdxJ AJE03112.1 AJE03112.1 AJE03085.1 AJE03085.1 AJE03084.1 AJE03084.1 AJE03016.1 AJE03016.1 kdsA kdsA leuA-2 leuA-2 AJE02972.1 AJE02972.1 AJE02863.1 AJE02863.1 leuA leuA AJE04813.1 AJE04813.1 AJE01979.1 AJE01979.1 AJE01989.1 AJE01989.1 AJE02026.1 AJE02026.1 AJE02048.1 AJE02048.1 AJE02096.1 AJE02096.1 AJE02098.1 AJE02098.1 AJE02149.1 AJE02149.1 AJE02154.1 AJE02154.1 AJE02160.1 AJE02160.1 AJE02201.1 AJE02201.1 dapA dapA AJE04777.1 AJE04777.1 moaA moaA AJE02317.1 AJE02317.1 hisA hisA hisF hisF tal tal AJE04790.1 AJE04790.1 AJE02485.1 AJE02485.1 AJE02494.1 AJE02494.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJE02495.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
AJE02654.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
AJE04710.1hydroxymethylglutaryl-CoA lyase; Catalyzes the formation of acetoacetate and acetyl-CoA from 3-hydroxy-3-methylglutaryl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (312 aa)
mqnERadical SAM protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (360 aa)
mqnCHypothetical protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (354 aa)
AJE04563.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (459 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (283 aa)
thiE-2Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (260 aa)
thiEPhosphomethylpyrimidine kinase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (488 aa)
AJE04150.1Nitrogenase cofactor biosynthesis protein NifB; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
AJE04919.1TIM barrel oxidoreductase NifR3; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (324 aa)
aksATrans-homoaconitate synthase; In Methanococcus jannaschii this protein catalyzes the condensation of alpha-ketoglutarate and acetyl-CoA to form trans-homoaconitate; functions in alphaketosuberate synthesis which is a precursor in coenzyme B and biotin synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (382 aa)
AJE03953.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1148 aa)
trpCIndole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. (266 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. (203 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (266 aa)
AJE03867.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
AJE03861.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (441 aa)
rlmN50S rRNA methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (344 aa)
AJE03774.1Hydrolase TatD; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
AJE03748.1Ketose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
AJE03740.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (355 aa)
AJE03738.1Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (476 aa)
guaBInosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (491 aa)
AJE04888.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
AJE03628.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate synthase family. (509 aa)
AJE03622.1Fructose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
AJE03611.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
AJE03545.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
AJE03496.1FeS-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)
AJE03461.1Nicotinate-nucleotide pyrophosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NadC/ModD family. (276 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (239 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (305 aa)
AJE03359.1Lysine 2,3-aminomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
queERadical SAM protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (250 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (329 aa)
AJE03158.1Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (528 aa)
AJE04731.1Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (383 aa)
pdxJPyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (239 aa)
AJE03112.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (437 aa)
AJE03085.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
AJE03084.1NADH:flavin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (653 aa)
AJE03016.12-nitropropane dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the KdsA family. (272 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (512 aa)
AJE02972.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
AJE02863.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (517 aa)
AJE04813.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
AJE01979.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
AJE01989.13-deoxy-7-phosphoheptulonate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
AJE02026.1Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa)
AJE02048.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1511 aa)
AJE02096.1Biotin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
AJE02098.1NADH-dependent flavin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
AJE02149.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (423 aa)
AJE02154.1Nitrogenase cofactor biosynthesis protein NifB; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
AJE02160.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
AJE02201.1Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. (325 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (290 aa)
AJE04777.1Dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (306 aa)
moaAMolybdenum cofactor biosynthesis protein MoeA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (326 aa)
AJE02317.13-deoxy-7-phosphoheptulonate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
hisACatalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-hosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
hisFImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (214 aa)
AJE04790.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
AJE02485.1Iron-sulfur cluster-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
AJE02494.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
Your Current Organism:
Geobacter pickeringii
NCBI taxonomy Id: 345632
Other names: DSM 17153, G. pickeringii, Geobacter pickeringii Shelobolina et al. 2007, JCM 13000, strain G13
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