STRINGSTRING
trpB-2 trpB-2 metZ metZ trpA trpA argJ argJ SEM27413.1 SEM27413.1 leuB leuB SEL20649.1 SEL20649.1 carA carA SEL22428.1 SEL22428.1 glyA glyA folD folD argD argD SEL27729.1 SEL27729.1 SEL30833.1 SEL30833.1 trpC trpC trpD trpD SEL20612.1 SEL20612.1 lysA lysA dapF dapF serC serC carB carB argG argG SEL43912.1 SEL43912.1 argC argC ilvA ilvA SEL45307.1 SEL45307.1 SEL47388.1 SEL47388.1 SEL47476.1 SEL47476.1 SEL47584.1 SEL47584.1 SEL40835.1 SEL40835.1 SEL42334.1 SEL42334.1 SEL56670.1 SEL56670.1 SEL57271.1 SEL57271.1 argH argH dapA dapA dapB dapB argA argA SEL59025.1 SEL59025.1 thrB thrB SEL52969.1 SEL52969.1 trpE trpE SEL67348.1 SEL67348.1 leuC leuC leuD leuD asd asd SEL69278.1 SEL69278.1 metXS metXS leuA leuA proA proA SEL65799.1 SEL65799.1 panD panD serS serS SEL78247.1 SEL78247.1 SEL74860.1 SEL74860.1 SEL84656.1 SEL84656.1 SEL84697.1 SEL84697.1 dapE dapE proB proB SEL90995.1 SEL90995.1 SEL88873.1 SEL88873.1 dapD dapD SEL94591.1 SEL94591.1 SEL96078.1 SEL96078.1 SEL96105.1 SEL96105.1 ilvE ilvE ilvC ilvC SEM02994.1 SEM02994.1 trpB trpB trpF trpF SEM07115.1 SEM07115.1 SEM06066.1 SEM06066.1 ilvD ilvD SEM13287.1 SEM13287.1 SEM13310.1 SEM13310.1 argB argB SEM20982.1 SEM20982.1 SEM21469.1 SEM21469.1 proC proC SEM23162.1 SEM23162.1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
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trpB-2Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (402 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (395 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa)
argJGlutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (406 aa)
SEM27413.1Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (367 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (359 aa)
SEL20649.1L-glutamine synthetase. (469 aa)
carACarbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (380 aa)
SEL22428.15,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. (278 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa)
argDAcetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (403 aa)
SEL27729.1Aspartate kinase; Belongs to the aspartokinase family. (426 aa)
SEL30833.1Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (356 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (268 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (348 aa)
SEL20612.1Anthranilate synthase, component II. (194 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (414 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (280 aa)
serCPhosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (360 aa)
carBCarbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1077 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (446 aa)
SEL43912.1Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (306 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (349 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (512 aa)
SEL45307.1L-proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1249 aa)
SEL47388.1Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (305 aa)
SEL47476.1Methionine synthase (B12-independent). (347 aa)
SEL47584.1Ribosomal protein S18 acetylase RimI. (167 aa)
SEL40835.1Aromatic-amino-acid transaminase. (401 aa)
SEL42334.1Putative acetyltransferase. (161 aa)
SEL56670.1Phosphoserine / homoserine phosphotransferase. (210 aa)
SEL57271.1Phosphoserine phosphatase. (406 aa)
argHArgininosuccinate lyase. (476 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
argAN-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. (450 aa)
SEL59025.1Adenosylhomocysteine nucleosidase. (188 aa)
thrBHomoserine kinase type II; Belongs to the pseudomonas-type ThrB family. (316 aa)
SEL52969.15-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. (63 aa)
trpEAnthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (497 aa)
SEL67348.1Protein of unknown function. (83 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (482 aa)
leuD3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (216 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (372 aa)
SEL69278.1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (170 aa)
metXSHomoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (386 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (565 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (421 aa)
SEL65799.1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa)
panDL-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa)
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (423 aa)
SEL78247.1Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1228 aa)
SEL74860.1Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa)
SEL84656.1Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. (244 aa)
SEL84697.1Phosphoserine phosphatase. (205 aa)
dapESuccinyldiaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (377 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (377 aa)
SEL90995.1Chorismate mutase. (369 aa)
SEL88873.1LysR family transcriptional regulator, cys regulon transcriptional activator; Belongs to the LysR transcriptional regulatory family. (309 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (273 aa)
SEL94591.1Glutamate synthase (NADPH) large subunit. (1493 aa)
SEL96078.1Homoserine dehydrogenase. (434 aa)
SEL96105.1L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (379 aa)
ilvEBranched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (308 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
SEM02994.1Acetolactate synthase, small subunit. (163 aa)
trpBTryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (414 aa)
trpFPhosphoribosylanthranilate isomerase; Belongs to the TrpF family. (214 aa)
SEM07115.1Glutamate synthase domain-containing protein 2; Belongs to the glutamate synthase family. (556 aa)
SEM06066.1Serine O-acetyltransferase. (270 aa)
ilvDDihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (595 aa)
SEM13287.1Protein of unknown function. (83 aa)
SEM13310.1Protein of unknown function. (79 aa)
argBN-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (301 aa)
SEM20982.1Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. (306 aa)
SEM21469.1Rieske [2Fe-2S] domain-containing protein; Belongs to the glutamate synthase family. (539 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (276 aa)
SEM23162.1Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (332 aa)
Your Current Organism:
Acinetobacter sp. DSM 11652
NCBI taxonomy Id: 346222
Other names: A. sp. DSM 11652, Acinetobacter hebeiensis
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