(81 nodes) Regulation of actin dynamics for phagocytic cup formation, and Focal adhesion network (Anopheles melas)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A182TD43	Uncharacterized protein. (1535 aa)
	A0A182TDN8	Uncharacterized protein. (357 aa)
	A0A182TEH6	Uncharacterized protein. (231 aa)
	A0A182TEK1	Uncharacterized protein; Belongs to the DapA family. (282 aa)
	A0A182TEK2	Urb2 domain-containing protein. (1463 aa)
	A0A182TF63	Uncharacterized protein. (753 aa)
	A0A182TF69	Uncharacterized protein. (672 aa)
	A0A182TH77	Protein kinase domain-containing protein. (210 aa)
	A0A182THP4	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (340 aa)
	A0A182TIB4	Uncharacterized protein. (241 aa)
	A0A182TIN6	Uncharacterized protein. (870 aa)
	A0A182TIV6	Uncharacterized protein. (447 aa)
	A0A182TJ27	Uncharacterized protein. (371 aa)
	A0A182TJN1	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. GMF subfamily. (138 aa)
	A0A182TK65	Uncharacterized protein. (1121 aa)
	A0A182TKS1	Uncharacterized protein; Belongs to the actin family. (418 aa)
	A0A182TL71	LIM domain-containing protein. (311 aa)
	A0A182TLE5	LIM zinc-binding domain-containing protein. (95 aa)
	A0A182TLI5	Uncharacterized protein. (280 aa)
	A0A182TNS1	Uncharacterized protein. (667 aa)
	A0A182TPA2	Uncharacterized protein. (351 aa)
	A0A182TPN4	Uncharacterized protein. (2755 aa)
	A0A182TQX4	I/LWEQ domain-containing protein. (428 aa)
	A0A182TR25	DUF2013 domain-containing protein. (772 aa)
	A0A182TRV9	Uncharacterized protein. (686 aa)
	A0A182TSZ6	Uncharacterized protein. (113 aa)
	A0A182TTA2	Uncharacterized protein. (722 aa)
	A0A182TTQ8	Uncharacterized protein. (694 aa)
	A0A182TTY6	Uncharacterized protein. (340 aa)
	A0A182TUD8	Adenylyl cyclase-associated protein; Belongs to the CAP family. (945 aa)
	A0A182TUJ5	Uncharacterized protein. (75 aa)
	A0A182TV53	Uncharacterized protein. (347 aa)
	A0A182TVD0	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
	A0A182TVD5	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (306 aa)
	A0A182TVR2	PH domain-containing protein. (668 aa)
	A0A182TWN5	Uncharacterized protein. (107 aa)
	A0A182TXM0	Uncharacterized protein. (123 aa)
	A0A182TXM7	Uncharacterized protein. (376 aa)
	A0A182TY29	Uncharacterized protein. (361 aa)
	A0A182TY73	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (296 aa)
	A0A182TYN7	Uncharacterized protein. (1697 aa)
	A0A182TYT2	Uncharacterized protein. (365 aa)
	A0A182TZK3	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (182 aa)
	A0A182U0C6	Uncharacterized protein. (480 aa)
	A0A182U0G0	Uncharacterized protein. (376 aa)
	A0A182U0I5	Profilin; Belongs to the profilin family. (89 aa)
	A0A182U1B9	Focal_AT domain-containing protein. (309 aa)
	A0A182U1L9	LIM zinc-binding domain-containing protein. (260 aa)
	A0A182U2G0	Uncharacterized protein. (245 aa)
	A0A182U2L1	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (374 aa)
	A0A182U3V6	Phorbol-ester/DAG-type domain-containing protein. (314 aa)
	A0A182U437	PH domain-containing protein. (617 aa)
	A0A182U458	Uncharacterized protein. (281 aa)
	A0A182U4I4	Uncharacterized protein. (151 aa)
	A0A182U5G3	SH3 domain-containing protein. (105 aa)
	A0A182U727	Uncharacterized protein. (556 aa)
	A0A182U758	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (128 aa)
	A0A182U766	Uncharacterized protein. (270 aa)
	A0A182U7M2	Uncharacterized protein. (950 aa)
	A0A182U965	Uncharacterized protein. (137 aa)
	A0A182U9H2	WD_REPEATS_REGION domain-containing protein. (597 aa)
	A0A182U9M5	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (129 aa)
	A0A182U9M9	Uncharacterized protein. (317 aa)
	A0A182UAH0	F-BAR domain-containing protein. (310 aa)
	A0A182UAK9	Uncharacterized protein. (1192 aa)
	A0A182UAM7	MR_MLE domain-containing protein. (229 aa)
	A0A182UBG4	Uncharacterized protein. (641 aa)
	A0A182UBK8	Uncharacterized protein. (126 aa)
	A0A182UCL1	Uncharacterized protein. (431 aa)
	A0A182UE49	PDZ domain-containing protein. (355 aa)
	A0A182UE86	Uncharacterized protein. (194 aa)
	A0A182UFL1	Uncharacterized protein. (259 aa)
	A0A182UGR4	Uncharacterized protein. (448 aa)
	A0A182UH94	Uncharacterized protein. (463 aa)
	A0A182UHL9	WH2 domain-containing protein. (638 aa)
	A0A182UJB6	Uncharacterized protein. (381 aa)
	A0A182UJD6	Uncharacterized protein. (553 aa)
	A0A182UKN9	Abi_HHR domain-containing protein. (316 aa)
	A0A182UKU7	Uncharacterized protein. (156 aa)
	A0A182ULB6	WH2 domain-containing protein. (655 aa)
	A0A182ULM9	Uncharacterized protein. (376 aa)

Your Current Organism:

Anopheles melas

NCBI taxonomy Id: 34690
Other names: A. melas

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182TD43	A0A182TDN8	Uncharacterized protein.	Uncharacterized protein.	0.693
A0A182TD43	A0A182TEH6	Uncharacterized protein.	Uncharacterized protein.	0.811
A0A182TD43	A0A182TF69	Uncharacterized protein.	Uncharacterized protein.	0.761
A0A182TD43	A0A182TH77	Uncharacterized protein.	Protein kinase domain-containing protein.	0.780
A0A182TD43	A0A182THP4	Uncharacterized protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.525
A0A182TD43	A0A182TKS1	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.501
A0A182TD43	A0A182TLE5	Uncharacterized protein.	LIM zinc-binding domain-containing protein.	0.811
A0A182TD43	A0A182TLI5	Uncharacterized protein.	Uncharacterized protein.	0.781
A0A182TD43	A0A182TNS1	Uncharacterized protein.	Uncharacterized protein.	0.761
A0A182TD43	A0A182TPN4	Uncharacterized protein.	Uncharacterized protein.	0.721
A0A182TD43	A0A182TQX4	Uncharacterized protein.	I/LWEQ domain-containing protein.	0.721
A0A182TD43	A0A182TR25	Uncharacterized protein.	DUF2013 domain-containing protein.	0.499
A0A182TD43	A0A182TSZ6	Uncharacterized protein.	Uncharacterized protein.	0.755
A0A182TD43	A0A182TTQ8	Uncharacterized protein.	Uncharacterized protein.	0.693
A0A182TD43	A0A182TV53	Uncharacterized protein.	Uncharacterized protein.	0.538
A0A182TD43	A0A182TVD5	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.755
A0A182TD43	A0A182TWN5	Uncharacterized protein.	Uncharacterized protein.	0.538
A0A182TD43	A0A182TXM7	Uncharacterized protein.	Uncharacterized protein.	0.538
A0A182TD43	A0A182TY29	Uncharacterized protein.	Uncharacterized protein.	0.665
A0A182TD43	A0A182U0G0	Uncharacterized protein.	Uncharacterized protein.	0.538