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A0A182UKK3 A0A182UKK3 A0A182TGC5 A0A182TGC5 A0A182TGP4 A0A182TGP4 A0A182THQ6 A0A182THQ6 A0A182THS3 A0A182THS3 A0A182TI60 A0A182TI60 A0A182TJV1 A0A182TJV1 A0A182TK31 A0A182TK31 A0A182TKA9 A0A182TKA9 A0A182TKL7 A0A182TKL7 A0A182TKZ0 A0A182TKZ0 A0A182TLB9 A0A182TLB9 A0A182TLC4 A0A182TLC4 A0A182TMI1 A0A182TMI1 A0A182TN77 A0A182TN77 A0A182TN89 A0A182TN89 A0A182TP10 A0A182TP10 A0A182TQ06 A0A182TQ06 A0A182TQZ6 A0A182TQZ6 A0A182TR65 A0A182TR65 A0A182TRK8 A0A182TRK8 A0A182TT82 A0A182TT82 A0A182TT84 A0A182TT84 A0A182TTI3 A0A182TTI3 A0A182TUD1 A0A182TUD1 A0A182TUH6 A0A182TUH6 A0A182TV02 A0A182TV02 A0A182TVD4 A0A182TVD4 A0A182TVK1 A0A182TVK1 A0A182TWA9 A0A182TWA9 A0A182TWL8 A0A182TWL8 A0A182TWM8 A0A182TWM8 A0A182TXC1 A0A182TXC1 A0A182TXM4 A0A182TXM4 A0A182TXN6 A0A182TXN6 A0A182TXV7 A0A182TXV7 A0A182TYW2 A0A182TYW2 A0A182TYW7 A0A182TYW7 A0A182TYX1 A0A182TYX1 A0A182TZB1 A0A182TZB1 A0A182TZD9 A0A182TZD9 A0A182U021 A0A182U021 A0A182U086 A0A182U086 A0A182U0Y9 A0A182U0Y9 A0A182U140 A0A182U140 A0A182U1B7 A0A182U1B7 A0A182U1D3 A0A182U1D3 A0A182U1I6 A0A182U1I6 A0A182U2D7 A0A182U2D7 A0A182U2U9 A0A182U2U9 A0A182U3Q4 A0A182U3Q4 A0A182U4V5 A0A182U4V5 A0A182U518 A0A182U518 A0A182U581 A0A182U581 A0A182U639 A0A182U639 A0A182U6G4 A0A182U6G4 A0A182U7T3 A0A182U7T3 A0A182U7T7 A0A182U7T7 A0A182U7V3 A0A182U7V3 A0A182U7Z7 A0A182U7Z7 A0A182U8D3 A0A182U8D3 A0A182U8K9 A0A182U8K9 A0A182U995 A0A182U995 A0A182U9I4 A0A182U9I4 A0A182UAI9 A0A182UAI9 A0A182UAP6 A0A182UAP6 A0A182UAY5 A0A182UAY5 A0A182UAZ6 A0A182UAZ6 A0A182UCF7 A0A182UCF7 A0A182UCN3 A0A182UCN3 A0A182UCV7 A0A182UCV7 A0A182UDJ4 A0A182UDJ4 A0A182UE82 A0A182UE82 A0A182UEI9 A0A182UEI9 A0A182UF09 A0A182UF09 A0A182UFB1 A0A182UFB1 A0A182UFH7 A0A182UFH7 A0A182UFW2 A0A182UFW2 A0A182UG57 A0A182UG57 A0A182UGE9 A0A182UGE9 A0A182UGM8 A0A182UGM8 A0A182UGR5 A0A182UGR5 A0A182UGV6 A0A182UGV6 A0A182UH47 A0A182UH47 A0A182UHI7 A0A182UHI7 A0A182UHR7 A0A182UHR7 A0A182UHV4 A0A182UHV4 A0A182UHX1 A0A182UHX1 A0A182UI87 A0A182UI87 A0A182UJ61 A0A182UJ61 A0A182UJB5 A0A182UJB5 wuho wuho A0A182UJQ7 A0A182UJQ7 A0A182UKC2 A0A182UKC2 A0A182UKE6 A0A182UKE6 A0A182UKY4 A0A182UKY4 A0A182UL20 A0A182UL20 A0A182UL89 A0A182UL89 A0A1I8JV57 A0A1I8JV57 A0A182TD64 A0A182TD64 A0A182TDC0 A0A182TDC0 A0A182TDK1 A0A182TDK1 A0A182TDZ8 A0A182TDZ8 A0A182TEM4 A0A182TEM4 A0A182TET6 A0A182TET6 A0A182TGA6 A0A182TGA6 A0A182TGA9 A0A182TGA9 A0A182TGC1 A0A182TGC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A182UKK3Uncharacterized protein. (685 aa)
A0A182TGC5Uncharacterized protein. (387 aa)
A0A182TGP4Uncharacterized protein. (263 aa)
A0A182THQ6Uncharacterized protein. (947 aa)
A0A182THS3Uncharacterized protein. (251 aa)
A0A182TI60CHHC U11-48K-type domain-containing protein. (432 aa)
A0A182TJV1Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (314 aa)
A0A182TK31tRNA (guanine(26)-N(2))-dimethyltransferase. (560 aa)
A0A182TKA9Queuosine salvage protein; Involved in salvaging queuosine. (347 aa)
A0A182TKL7Fe2OG dioxygenase domain-containing protein. (619 aa)
A0A182TKZ0Uncharacterized protein. (299 aa)
A0A182TLB9Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. (450 aa)
A0A182TLC4Methyltransf_11 domain-containing protein. (670 aa)
A0A182TMI1Sen15 domain-containing protein. (166 aa)
A0A182TN77Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (145 aa)
A0A182TN89SpoU_methylase domain-containing protein. (1403 aa)
A0A182TP10Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (967 aa)
A0A182TQ06Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (407 aa)
A0A182TQZ6TrmE-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (495 aa)
A0A182TR65Uncharacterized protein. (464 aa)
A0A182TRK8Uncharacterized protein. (218 aa)
A0A182TT82Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (346 aa)
A0A182TT84Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (307 aa)
A0A182TTI3Uncharacterized protein. (419 aa)
A0A182TUD1Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (197 aa)
A0A182TUH6tRNA pseudouridine synthase. (460 aa)
A0A182TV02Uncharacterized protein. (456 aa)
A0A182TVD4Alba domain-containing protein. (225 aa)
A0A182TVK1Uncharacterized protein. (744 aa)
A0A182TWA9DTW domain-containing protein. (265 aa)
A0A182TWL8tRNA_int_end_N2 domain-containing protein. (352 aa)
A0A182TWM8Uncharacterized protein. (211 aa)
A0A182TXC1Uncharacterized protein. (465 aa)
A0A182TXM4Ubiquitin-related modifier 1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxid [...] (109 aa)
A0A182TXN6Uncharacterized protein; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (428 aa)
A0A182TXV7Uncharacterized protein. (958 aa)
A0A182TYW2Uncharacterized protein. (244 aa)
A0A182TYW7A to I editase domain-containing protein. (457 aa)
A0A182TYX1Mitochondrial alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (1011 aa)
A0A182TZB1tRNA-dihydrouridine(47) synthase [NAD(P)(+)]. (610 aa)
A0A182TZD9Uncharacterized protein. (285 aa)
A0A182U021tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. (235 aa)
A0A182U086Uncharacterized protein. (258 aa)
A0A182U0Y9Uncharacterized protein. (306 aa)
A0A182U140Uncharacterized protein. (324 aa)
A0A182U1B7tRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family. (317 aa)
A0A182U1D3DUF2428 domain-containing protein. (1301 aa)
A0A182U1I6tRNA_int_endo domain-containing protein. (172 aa)
A0A182U2D7Uncharacterized protein. (308 aa)
A0A182U2U9TRUD domain-containing protein. (704 aa)
A0A182U3Q4Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. (342 aa)
A0A182U4V5Uncharacterized protein. (750 aa)
A0A182U518tRNA pseudouridine synthase. (454 aa)
A0A182U581Uncharacterized protein. (553 aa)
A0A182U639Uncharacterized protein. (510 aa)
A0A182U6G4SAM-dependent MTase TRM10-type domain-containing protein. (294 aa)
A0A182U7T3Uncharacterized protein. (129 aa)
A0A182U7T7Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (415 aa)
A0A182U7V3Uncharacterized protein. (342 aa)
A0A182U7Z7Fibrinogen C-terminal domain-containing protein. (732 aa)
A0A182U8D3Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (255 aa)
A0A182U8K9Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (548 aa)
A0A182U995Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] (441 aa)
A0A182U9I4Uncharacterized protein. (217 aa)
A0A182UAI9Uncharacterized protein. (794 aa)
A0A182UAP6tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (287 aa)
A0A182UAY5Uncharacterized protein. (113 aa)
A0A182UAZ6Uncharacterized protein. (412 aa)
A0A182UCF7Protein CLP1 homolog; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation; Belongs to the Clp1 family. Clp1 subfamily. (423 aa)
A0A182UCN3C2H2-type domain-containing protein. (263 aa)
A0A182UCV7Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (432 aa)
A0A182UDJ4Uncharacterized protein. (828 aa)
A0A182UE82DRBM domain-containing protein. (506 aa)
A0A182UEI9Uncharacterized protein. (101 aa)
A0A182UF09Uncharacterized protein. (477 aa)
A0A182UFB1RNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs; Belongs to the RtcB family. (506 aa)
A0A182UFH7tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (437 aa)
A0A182UFW2Rhodanese domain-containing protein. (837 aa)
A0A182UG57tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (483 aa)
A0A182UGE9GIDA_assoc domain-containing protein. (666 aa)
A0A182UGM8tRNA (guanine(26)-N(2))-dimethyltransferase. (573 aa)
A0A182UGR5DTW domain-containing protein. (309 aa)
A0A182UGV6SAM-dependent MTase TRM10-type domain-containing protein. (347 aa)
A0A182UH47Uncharacterized protein. (412 aa)
A0A182UHI7Uncharacterized protein; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (485 aa)
A0A182UHR7Hflx-type G domain-containing protein. (463 aa)
A0A182UHV4Uncharacterized protein. (794 aa)
A0A182UHX1CMP/dCMP-type deaminase domain-containing protein. (167 aa)
A0A182UI87Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (377 aa)
A0A182UJ61DNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (339 aa)
A0A182UJB5PPR_long domain-containing protein. (678 aa)
wuhotRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wuho; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (382 aa)
A0A182UJQ7Uncharacterized protein. (1226 aa)
A0A182UKC2ATP_bind_3 domain-containing protein. (254 aa)
A0A182UKE6Uncharacterized protein. (716 aa)
A0A182UKY4Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1326 aa)
A0A182UL20SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (707 aa)
A0A182UL89Uncharacterized protein. (115 aa)
A0A1I8JV57UPF0020 domain-containing protein. (487 aa)
A0A182TD64C3H1-type domain-containing protein. (587 aa)
A0A182TDC0TsaA-like domain-containing protein. (275 aa)
A0A182TDK1Archease domain-containing protein. (157 aa)
A0A182TDZ8THUMP domain-containing protein. (338 aa)
A0A182TEM4MTTase N-terminal domain-containing protein. (763 aa)
A0A182TET6DALR_1 domain-containing protein. (406 aa)
A0A182TGA6CMP/dCMP-type deaminase domain-containing protein. (380 aa)
A0A182TGA9Uncharacterized protein. (250 aa)
A0A182TGC1Uncharacterized protein. (287 aa)
Your Current Organism:
Anopheles melas
NCBI taxonomy Id: 34690
Other names: A. melas
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