(54 nodes) Neuron remodeling network (Anopheles melas)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A182U2B5	Uncharacterized protein. (145 aa)
	A0A182U321	Uncharacterized protein. (125 aa)
	A0A182U4F7	Uncharacterized protein. (300 aa)
	A0A182U4J4	USP8_dimer domain-containing protein. (587 aa)
	A0A182U4T8	Nuclear receptor domain-containing protein. (229 aa)
	A0A182U667	MIT domain-containing protein. (184 aa)
	A0A182U6E6	Uncharacterized protein; Belongs to the peptidase C2 family. (910 aa)
	A0A182U974	Calponin-homology (CH) domain-containing protein. (808 aa)
	A0A182U9Q7	BRO1 domain-containing protein. (1490 aa)
	A0A182UAG0	Protein kinase domain-containing protein. (764 aa)
	A0A182UAU3	Uncharacterized protein. (161 aa)
	A0A182UB18	HMG box domain-containing protein. (644 aa)
	A0A182UCK8	NR LBD domain-containing protein. (164 aa)
	A0A182UDV9	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (578 aa)
	A0A182UEF9	Uncharacterized protein. (720 aa)
	A0A182UES6	LIM zinc-binding domain-containing protein. (2543 aa)
	A0A182UF16	Uncharacterized protein. (292 aa)
	A0A182UGC4	SMC hinge domain-containing protein. (274 aa)
	A0A182UGU5	Uncharacterized protein. (749 aa)
	A0A182UHN0	Nuclear receptor domain-containing protein. (250 aa)
	A0A182UHQ9	Uncharacterized protein; Belongs to the peptidase C14A family. (293 aa)
	A0A182UIM2	Uncharacterized protein. (4991 aa)
	A0A182UJ80	Uncharacterized protein. (608 aa)
	A0A182UJW1	RRM domain-containing protein. (497 aa)
	A0A182UKE0	Uncharacterized protein. (311 aa)
	A0A182UL84	Uncharacterized protein. (431 aa)
	A0A182ULG3	Uncharacterized protein. (280 aa)
	A0A182ULE2	Uncharacterized protein. (424 aa)
	A0A182TEU6	BMERB domain-containing protein. (1513 aa)
	A0A182TGE0	Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (286 aa)
	A0A182THL7	Uncharacterized protein. (395 aa)
	A0A182THQ5	Uncharacterized protein. (260 aa)
	A0A182TI04	PID domain-containing protein. (731 aa)
	A0A182TIZ0	AAA domain-containing protein; Belongs to the AAA ATPase family. (270 aa)
	A0A182TJP7	Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (159 aa)
	A0A182TK08	Uncharacterized protein. (981 aa)
	A0A182TKT8	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (777 aa)
	A0A182TLR7	SMC hinge domain-containing protein. (613 aa)
	A0A182TP28	Uncharacterized protein. (225 aa)
	A0A182TQS8	Chromo domain-containing protein. (508 aa)
	A0A182TRC9	Uncharacterized protein. (1256 aa)
	A0A182TVN2	Uncharacterized protein; Belongs to the peptidase C2 family. (908 aa)
	A0A182TWF9	Uncharacterized protein; Belongs to the peptidase C2 family. (696 aa)
	A0A182TX43	Uncharacterized protein. (197 aa)
	A0A182TXD9	Uncharacterized protein; Belongs to the peptidase C14A family. (313 aa)
	A0A182TY13	Uncharacterized protein. (161 aa)
	A0A182TYD7	SMC_N domain-containing protein. (663 aa)
	A0A182TYG2	USP domain-containing protein; Belongs to the peptidase C19 family. (350 aa)
	A0A182TZ10	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (210 aa)
	A0A182U0E3	Uncharacterized protein. (66 aa)
	A0A182U0I5	Profilin; Belongs to the profilin family. (89 aa)
	A0A182U0N2	Uncharacterized protein. (826 aa)
	A0A182U0P9	Uncharacterized protein. (131 aa)
	A0A182U0U0	UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. (801 aa)

Your Current Organism:

Anopheles melas

NCBI taxonomy Id: 34690
Other names: A. melas

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182TGE0	A0A182TP28	Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family.	Uncharacterized protein.	0.406
A0A182TGE0	A0A182U0P9	Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family.	Uncharacterized protein.	0.406
A0A182THL7	A0A182TIZ0	Uncharacterized protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.693
A0A182THL7	A0A182TKT8	Uncharacterized protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.990
A0A182THL7	A0A182TP28	Uncharacterized protein.	Uncharacterized protein.	0.834
A0A182THL7	A0A182TZ10	Uncharacterized protein.	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	0.999
A0A182THL7	A0A182U0P9	Uncharacterized protein.	Uncharacterized protein.	0.834
A0A182THL7	A0A182U667	Uncharacterized protein.	MIT domain-containing protein.	0.693
A0A182THL7	A0A182U9Q7	Uncharacterized protein.	BRO1 domain-containing protein.	0.766
A0A182THL7	A0A182UGU5	Uncharacterized protein.	Uncharacterized protein.	0.957
A0A182THQ5	A0A182UCK8	Uncharacterized protein.	NR LBD domain-containing protein.	0.581
A0A182THQ5	A0A182UHN0	Uncharacterized protein.	Nuclear receptor domain-containing protein.	0.581
A0A182THQ5	A0A182ULG3	Uncharacterized protein.	Uncharacterized protein.	0.581
A0A182TI04	A0A182TK08	PID domain-containing protein.	Uncharacterized protein.	0.679
A0A182TI04	A0A182TKT8	PID domain-containing protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.513
A0A182TI04	A0A182TXD9	PID domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.452
A0A182TI04	A0A182UEF9	PID domain-containing protein.	Uncharacterized protein.	0.679
A0A182TI04	A0A182UHQ9	PID domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.452
A0A182TIZ0	A0A182THL7	AAA domain-containing protein; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.693
A0A182TIZ0	A0A182TKT8	AAA domain-containing protein; Belongs to the AAA ATPase family.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.656