(8 nodes) Rb-E2F complex, and TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest network (Anopheles quadriannulatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A182X923	Uncharacterized protein. (967 aa)
	A0A182X964	Transcription factor. (391 aa)
	A0A182XAX4	Uncharacterized protein; Belongs to the cyclin family. (356 aa)
	A0A182XBE6	E2F_TDP domain-containing protein. (807 aa)
	A0A182XGB9	E2F_TDP domain-containing protein. (494 aa)
	A0A182XKY1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (671 aa)
	A0A182XMG3	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
	A0A182XRL2	Uncharacterized protein. (262 aa)

Your Current Organism:

Anopheles quadriannulatus

NCBI taxonomy Id: 34691
Other names: A. quadriannulatus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182X923	A0A182X964	Uncharacterized protein.	Transcription factor.	0.989
A0A182X923	A0A182XAX4	Uncharacterized protein.	Uncharacterized protein; Belongs to the cyclin family.	0.879
A0A182X923	A0A182XBE6	Uncharacterized protein.	E2F_TDP domain-containing protein.	0.983
A0A182X923	A0A182XGB9	Uncharacterized protein.	E2F_TDP domain-containing protein.	0.996
A0A182X923	A0A182XKY1	Uncharacterized protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.976
A0A182X923	A0A182XMG3	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.879
A0A182X923	A0A182XRL2	Uncharacterized protein.	Uncharacterized protein.	0.921
A0A182X964	A0A182X923	Transcription factor.	Uncharacterized protein.	0.989
A0A182X964	A0A182XAX4	Transcription factor.	Uncharacterized protein; Belongs to the cyclin family.	0.719
A0A182X964	A0A182XBE6	Transcription factor.	E2F_TDP domain-containing protein.	0.989
A0A182X964	A0A182XGB9	Transcription factor.	E2F_TDP domain-containing protein.	0.993
A0A182X964	A0A182XKY1	Transcription factor.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.815
A0A182X964	A0A182XMG3	Transcription factor.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.724
A0A182X964	A0A182XRL2	Transcription factor.	Uncharacterized protein.	0.727
A0A182XAX4	A0A182X923	Uncharacterized protein; Belongs to the cyclin family.	Uncharacterized protein.	0.879
A0A182XAX4	A0A182X964	Uncharacterized protein; Belongs to the cyclin family.	Transcription factor.	0.719
A0A182XAX4	A0A182XBE6	Uncharacterized protein; Belongs to the cyclin family.	E2F_TDP domain-containing protein.	0.859
A0A182XAX4	A0A182XGB9	Uncharacterized protein; Belongs to the cyclin family.	E2F_TDP domain-containing protein.	0.859
A0A182XAX4	A0A182XKY1	Uncharacterized protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.854
A0A182XAX4	A0A182XMG3	Uncharacterized protein; Belongs to the cyclin family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.871