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NP_0200A NP_0200A serA1 serA1 serB serB hom hom lysC lysC leuA2 leuA2 pabC pabC NP_0884A NP_0884A ilvA ilvA dapA dapA dapB dapB dapD dapD thrC3 thrC3 lysA lysA ilvB2 ilvB2 asd asd leuB leuB leuD leuD leuC leuC ilvC ilvC ilvN ilvN ilvB1 ilvB1 leuA3 leuA3 proC proC proB proB proA proA NP_4078A NP_4078A thrC2 thrC2 thrB thrB ilvD ilvD ilvE1 ilvE1 argG argG argH argH argW argW argX argX argC argC argB argB argD argD argE argE argF argF thrC1 thrC1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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NP_0200APeptidase M20 family protein (homolog to succinyl-diaminopimelate desuccinylase). (248 aa)
serA1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (526 aa)
serBPhosphoserine phosphatase. (234 aa)
homHomoserine dehydrogenase. (315 aa)
lysCAspartate kinase; Belongs to the aspartokinase family. (394 aa)
leuA22-isopropylmalate synthase / (R)-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (511 aa)
pabCAminodeoxychorismate lyase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (284 aa)
NP_0884APyridoxal phosphate-dependent aminotransferase. (367 aa)
ilvAThreonine ammonia-lyase. (402 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (246 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. (278 aa)
thrC3Threonine synthase. (388 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (410 aa)
ilvB2Benzoylformate decarboxylase; Thiamine pyrophosphate-dependent enzyme (homolog to acetolactate synthase / benzoylformate decarboxylase); Belongs to the TPP enzyme family. (564 aa)
asdAspartate-semialdehyde dehydrogenase. (345 aa)
leuB3-isopropylmalate dehydrogenase. (325 aa)
leuD3-isopropylmalate dehydratase small subunit. (214 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa)
ilvNAcetolactate synthase small subunit. (210 aa)
ilvB1Acetolactate synthase large subunit. (581 aa)
leuA3Homolog to 2-isopropylmalate synthase / homocitrate synthase / (R)-citramalate synthase. (296 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (257 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (284 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (438 aa)
NP_4078AM20 family amidohydrolase (homolog to indole-3-acetyl-aspartate hydrolase). (423 aa)
thrC2Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (409 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (291 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (593 aa)
ilvE1Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (312 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (400 aa)
argHArgininosuccinate lyase. (490 aa)
argWProbable biosynthetic carrier protein ArgW. (54 aa)
argXPutative glutamate--argW ligase. (287 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (346 aa)
argBAcetylglutamate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (277 aa)
argDAcetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (375 aa)
argEAcetylornithine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (349 aa)
argFOrnithine carbamoyltransferase. (294 aa)
thrC1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (419 aa)
Your Current Organism:
Natronomonas pharaonis
NCBI taxonomy Id: 348780
Other names: N. pharaonis DSM 2160, Natronomonas pharaonis ATCC 35678, Natronomonas pharaonis DSM 2160, Natronomonas pharaonis Gabara, Natronomonas pharaonis JCM 8858, Natronomonas pharaonis str. DSM 2160, Natronomonas pharaonis strain DSM 2160
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