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crtI2 crtI2 idiB idiB hmgA2 hmgA2 NP_0506A NP_0506A NP_0508A NP_0508A NP_0510A NP_0510A NP_0512A NP_0512A NP_0514A NP_0514A idsA2 idsA2 carS carS pcrB pcrB mvaD mvaD NP_1630A NP_1630A NP_1688A NP_1688A NP_1690A NP_1690A hmgA1 hmgA1 NP_2774A NP_2774A mvk mvk NP_2852A NP_2852A NP_3024A NP_3024A idsA3 idsA3 NP_4168A NP_4168A ubiA2 ubiA2 gldA gldA NP_4540A NP_4540A NP_4542A NP_4542A uppS2 uppS2 uppS1 uppS1 idsA1 idsA1 NP_4564A NP_4564A crtD crtD lyeJ lyeJ cruF cruF crtB crtB idiA idiA
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
crtI2Phytoene dehydrogenase (phytoene desaturase). (510 aa)
idiBIsopentenyl-diphosphate delta-isomerase, type II; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (358 aa)
hmgA2hydroxymethylglutaryl-CoA reductase (NADPH). (539 aa)
NP_0506ASmall CPxCG-related zinc finger protein. (136 aa)
NP_0508ADUF3426 domain protein. (178 aa)
NP_0510AUncharacterized protein. (219 aa)
NP_0512AFAD-dependent oxidoreductase (homolog to geranylgeranyl reductase). (361 aa)
NP_0514AUncharacterized protein. (206 aa)
idsA2Bifunctional short chain isoprenyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (291 aa)
carSCDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (189 aa)
pcrB(S)-3-O-geranylgeranylglyceryl phosphate synthase 1; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (235 aa)
mvaDPhosphomevalonate decarboxylase. (324 aa)
NP_1630AAmine oxidase domain protein. (418 aa)
NP_1688ABeta-lactamase domain protein. (298 aa)
NP_1690AUncharacterized protein. (287 aa)
hmgA1hydroxymethylglutaryl-CoA reductase (NADPH); Belongs to the HMG-CoA reductase family. (402 aa)
NP_2774AHAD superfamily hydrolase. (261 aa)
mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (329 aa)
NP_2852AIsopentenyl phosphate kinase; Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. (243 aa)
NP_3024AFAD-dependent oxidoreductase (homolog to geranylgeranyl reductase). (451 aa)
idsA3Bifunctional short chain isoprenyl diphosphate synthase; Probably involved in biosynthesis of the precursor for C25 (sesterterpanyl chain) moiety of C20-C25 diether (2-O-sesterterpanyl-3- O-phytanyl-sn-glycer) membrane lipid. Catalyzes the condensation of isopentenyl pyrophosphate with the allylic pyrophosphates to yield geranylfarnesyl diphosphate (GFPP). Geranylgeranyl diphosphate (GGPP) is the preferred substrate, but dimethylallyl diphosphate (DMAPP) and farnesyl diphosphate (FPP) can also be used as allylic substrate. (341 aa)
NP_4168AFAD-dependent oxidoreductase (homolog to geranylgeranyl reductase). (456 aa)
ubiA2(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (277 aa)
gldAGlycerol-1-phosphate dehydrogenase (NAD(P)); Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Belongs to the glycerol-1-phosphate dehydrogenase family. (352 aa)
NP_4540AGNAT family acetyltransferase. (135 aa)
NP_4542ADUF92 family protein. (440 aa)
uppS2Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific). (202 aa)
uppS1Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific); Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids. (306 aa)
idsA1Bifunctional short chain isoprenyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (353 aa)
NP_4564AFAD-dependent oxidoreductase (homolog to geranylgeranyl reductase). (457 aa)
crtDCarotenoid 3,4-desaturase. (492 aa)
lyeJLycopene elongase / lycopene 1,2-hydratase. (290 aa)
cruFBisanhydrobacterioruberin hydratase. (275 aa)
crtBPhytoene synthase. (318 aa)
idiAIsopentenyl-diphosphate delta-isomerase, type I. (188 aa)
Your Current Organism:
Natronomonas pharaonis
NCBI taxonomy Id: 348780
Other names: N. pharaonis DSM 2160, Natronomonas pharaonis ATCC 35678, Natronomonas pharaonis DSM 2160, Natronomonas pharaonis Gabara, Natronomonas pharaonis JCM 8858, Natronomonas pharaonis str. DSM 2160, Natronomonas pharaonis strain DSM 2160
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