(29 nodes) Glycolysis / Gluconeogenesis network (Natronomonas pharaonis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	gap	Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating). (338 aa)
	lpdA	Dihydrolipoyl dehydrogenase. (474 aa)
	acs5	acyl-CoA synthetase. (544 aa)
	dsa	Dihydrolipoamide S-acyltransferase. (516 aa)
	oxdhB	2-oxo-3-methylvalerate dehydrogenase E1 component beta subunit. (329 aa)
	oxdhA1	2-oxo-3-methylvalerate dehydrogenase E1 component alpha subunit. (374 aa)
	ppsA	Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (759 aa)
	korA	Oxoglutarate--ferredoxin oxidoreductase alpha subunit. (587 aa)
	korB1	Oxoglutarate--ferredoxin oxidoreductase beta subunit. (289 aa)
	fbp	Fructose-1,6-bisphosphatase. (283 aa)
	fba1	Fructose-bisphosphate aldolase, class 1. (264 aa)
	pykA	Pyruvate kinase; Belongs to the pyruvate kinase family. (593 aa)
	gpmI	Phosphoglycerate mutase, 2,3-biphosphateglycerate-independent type; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (506 aa)
	tpiA1	Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (215 aa)
	oxdhA2	Probable 2-oxoacid dehydrogenase E1 component alpha subunit. (379 aa)
	eno	Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (398 aa)
	acdA	acetate--CoA ligase (ADP-forming). (697 aa)
	aldH2	Aldehyde dehydrogenase. (505 aa)
	fba2	2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (262 aa)
	tpiA2	Triosephosphate isomerase. (230 aa)
	porB	Pyruvate--ferredoxin oxidoreductase beta subunit. (311 aa)
	porA	Pyruvate--ferredoxin oxidoreductase alpha subunit. (629 aa)
	pgk	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (396 aa)
	acs1	acyl-CoA synthetase. (655 aa)
	acs2	acyl-CoA synthetase. (560 aa)
	pgi	Glucose-6-phosphate isomerase; Belongs to the GPI family. (428 aa)
	acs3	acyl-CoA synthetase. (662 aa)
	acs4	acyl-CoA synthetase. (657 aa)
	pmm4	Phosphohexomutase (phosphoglucomutase / phosphomannomutase). (458 aa)

Your Current Organism:

Natronomonas pharaonis

NCBI taxonomy Id: 348780
Other names: N. pharaonis DSM 2160, Natronomonas pharaonis ATCC 35678, Natronomonas pharaonis DSM 2160, Natronomonas pharaonis Gabara, Natronomonas pharaonis JCM 8858, Natronomonas pharaonis str. DSM 2160, Natronomonas pharaonis strain DSM 2160

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
acdA	acs1	NP_2858A	NP_4240A	acetate--CoA ligase (ADP-forming).	acyl-CoA synthetase.	0.929
acdA	acs2	NP_2858A	NP_4242A	acetate--CoA ligase (ADP-forming).	acyl-CoA synthetase.	0.918
acdA	acs3	NP_2858A	NP_5128A	acetate--CoA ligase (ADP-forming).	acyl-CoA synthetase.	0.918
acdA	acs4	NP_2858A	NP_5132A	acetate--CoA ligase (ADP-forming).	acyl-CoA synthetase.	0.918
acdA	acs5	NP_2858A	NP_0164A	acetate--CoA ligase (ADP-forming).	acyl-CoA synthetase.	0.918
acdA	aldH2	NP_2858A	NP_3020A	acetate--CoA ligase (ADP-forming).	Aldehyde dehydrogenase.	0.918
acdA	dsa	NP_2858A	NP_0556A	acetate--CoA ligase (ADP-forming).	Dihydrolipoamide S-acyltransferase.	0.905
acdA	gap	NP_2858A	NP_0012A	acetate--CoA ligase (ADP-forming).	Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating).	0.404
acdA	korA	NP_2858A	NP_1232A	acetate--CoA ligase (ADP-forming).	Oxoglutarate--ferredoxin oxidoreductase alpha subunit.	0.948
acdA	korB1	NP_2858A	NP_1234A	acetate--CoA ligase (ADP-forming).	Oxoglutarate--ferredoxin oxidoreductase beta subunit.	0.919
acdA	oxdhA1	NP_2858A	NP_0560A	acetate--CoA ligase (ADP-forming).	2-oxo-3-methylvalerate dehydrogenase E1 component alpha subunit.	0.809
acdA	oxdhA2	NP_2858A	NP_2542A	acetate--CoA ligase (ADP-forming).	Probable 2-oxoacid dehydrogenase E1 component alpha subunit.	0.809
acdA	oxdhB	NP_2858A	NP_0558A	acetate--CoA ligase (ADP-forming).	2-oxo-3-methylvalerate dehydrogenase E1 component beta subunit.	0.826
acdA	porA	NP_2858A	NP_4046A	acetate--CoA ligase (ADP-forming).	Pyruvate--ferredoxin oxidoreductase alpha subunit.	0.960
acdA	porB	NP_2858A	NP_4044A	acetate--CoA ligase (ADP-forming).	Pyruvate--ferredoxin oxidoreductase beta subunit.	0.919
acs1	acdA	NP_4240A	NP_2858A	acyl-CoA synthetase.	acetate--CoA ligase (ADP-forming).	0.929
acs1	acs2	NP_4240A	NP_4242A	acyl-CoA synthetase.	acyl-CoA synthetase.	0.708
acs1	acs3	NP_4240A	NP_5128A	acyl-CoA synthetase.	acyl-CoA synthetase.	0.698
acs1	acs4	NP_4240A	NP_5132A	acyl-CoA synthetase.	acyl-CoA synthetase.	0.693
acs1	acs5	NP_4240A	NP_0164A	acyl-CoA synthetase.	acyl-CoA synthetase.	0.708

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