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pyrD pyrD dut dut pyrE pyrE upp upp pyrC pyrC pyrF pyrF pyrG pyrG pyrH pyrH tmk tmk ushA2 ushA2 hts hts udp2 udp2 nrdJ nrdJ udp1 udp1 cdd cdd pyrB pyrB pyrI pyrI ndk ndk surE surE nrdB3 nrdB3 carB carB carA carA cmk cmk nrdB2 nrdB2 dcd dcd
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pyrDDihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (350 aa)
dutdUTP diphosphatase. (153 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (173 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (223 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (422 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (269 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (548 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (227 aa)
tmkThymidylate kinase. (196 aa)
ushA25'-nucleotidase family hydrolase. (453 aa)
htsThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (342 aa)
udp2Uridine phosphorylase. (241 aa)
nrdJRibonucleoside-diphosphate reductase,adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1041 aa)
udp1Uridine phosphorylase. (267 aa)
cddCytidine deaminase. (130 aa)
pyrBAspartate carbamoyltransferase catalytic subunit. (300 aa)
pyrIAspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (153 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (153 aa)
surE5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (257 aa)
nrdB3Probable ribonucleoside-diphosphate reductase beta subunit. (316 aa)
carBCarbamoyl-phosphate synthase (glutamine-hydrolyzing) large subunit; Belongs to the CarB family. (1077 aa)
carACarbamoyl-phosphate synthase (glutamine-hydrolyzing) small subunit; Belongs to the CarA family. (352 aa)
cmkCytidylate kinase. (192 aa)
nrdB2Probable ribonucleoside-diphosphate reductase beta subunit. (306 aa)
dcddCTP deaminase; Catalyzes the deamination of dCTP to dUTP. (195 aa)
Your Current Organism:
Natronomonas pharaonis
NCBI taxonomy Id: 348780
Other names: N. pharaonis DSM 2160, Natronomonas pharaonis ATCC 35678, Natronomonas pharaonis DSM 2160, Natronomonas pharaonis Gabara, Natronomonas pharaonis JCM 8858, Natronomonas pharaonis str. DSM 2160, Natronomonas pharaonis strain DSM 2160
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