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gap gap glnA1 glnA1 hisH hisH pheA pheA NP_0200A NP_0200A serA1 serA1 serB serB metX metX hom hom citB1 citB1 hisE hisE trpD2 trpD2 lysC lysC prsA prsA leuA2 leuA2 rpiA rpiA pabC pabC pabA pabA pabB pabB aroE aroE hisG hisG ilvA ilvA hisA hisA citZ citZ dapA dapA dapB dapB dapD dapD fba1 fba1 thrC3 thrC3 lysA lysA aspC2 aspC2 pykA pykA gpmI gpmI asd asd citB2 citB2 glyA glyA hisC hisC tpiA1 tpiA1 leuB leuB leuD leuD leuC leuC ilvC ilvC ilvN ilvN ilvB1 ilvB1 aroD aroD hisB hisB icd icd eno eno hisD hisD asnB asnB leuA3 leuA3 trpD3 trpD3 aroA aroA aroC aroC mat mat cysK2 cysK2 fba2 fba2 trpA trpA trpB1 trpB1 trpC trpC trpD1 trpD1 trpF trpF trpE1 trpE1 trpG1 trpG1 tyrA tyrA trpB2 trpB2 metE1 metE1 metE2 metE2 tpiA2 tpiA2 proC proC proB proB proA proA aroQ aroQ aroK aroK pgk pgk hisF hisF cysE cysE glnA2 glnA2 aspC3 aspC3 thrC2 thrC2 thrB thrB cysK1 cysK1 ilvD ilvD ilvE1 ilvE1 hisI hisI argG argG argH argH argX argX argC argC argB argB argD argD argE argE argF argF thrC1 thrC1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
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gene co-occurrence
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textmining
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Your Input:
gapGlyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating). (338 aa)
glnA1Glutamine synthetase. (456 aa)
hisHImidazoleglycerol-phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (215 aa)
pheAPrephenate dehydratase. (267 aa)
NP_0200APeptidase M20 family protein (homolog to succinyl-diaminopimelate desuccinylase). (248 aa)
serA1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (526 aa)
serBPhosphoserine phosphatase. (234 aa)
metXHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (401 aa)
homHomoserine dehydrogenase. (315 aa)
citB1Aconitate hydratase. (657 aa)
hisEphosphoribosyl-ATP pyrophosphatase. (101 aa)
trpD2Probable phosphoribosyltransferase (homolog to anthranilate phosphoribosyltransferase). (358 aa)
lysCAspartate kinase; Belongs to the aspartokinase family. (394 aa)
prsARibose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (277 aa)
leuA22-isopropylmalate synthase / (R)-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (511 aa)
rpiARibose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (225 aa)
pabCAminodeoxychorismate lyase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (284 aa)
pabAAminodeoxychorismate synthase component 2. (200 aa)
pabBAminodeoxychorismate synthase component 1. (496 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (264 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (281 aa)
ilvAThreonine ammonia-lyase. (402 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (239 aa)
citZCitrate synthase; Unknown EC_number=2.3.3.16. (378 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (246 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. (278 aa)
fba1Fructose-bisphosphate aldolase, class 1. (264 aa)
thrC3Threonine synthase. (388 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (410 aa)
aspC2Pyridoxal phosphate-dependent aminotransferase. (373 aa)
pykAPyruvate kinase; Belongs to the pyruvate kinase family. (593 aa)
gpmIPhosphoglycerate mutase, 2,3-biphosphateglycerate-independent type; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (506 aa)
asdAspartate-semialdehyde dehydrogenase. (345 aa)
citB2Aconitate hydratase. (917 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa)
hisCHistidinol-phosphate aminotransferase. (355 aa)
tpiA1Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (215 aa)
leuB3-isopropylmalate dehydrogenase. (325 aa)
leuD3-isopropylmalate dehydratase small subunit. (214 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa)
ilvNAcetolactate synthase small subunit. (210 aa)
ilvB1Acetolactate synthase large subunit. (581 aa)
aroD3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (225 aa)
hisBImidazoleglycerol-phosphate dehydratase. (195 aa)
icdIsocitrate dehydrogenase (NADP). (418 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (398 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (422 aa)
asnBAsparagine synthase (glutamine-hydrolyzing). (362 aa)
leuA3Homolog to 2-isopropylmalate synthase / homocitrate synthase / (R)-citramalate synthase. (296 aa)
trpD3Probable phosphoribosyltransferase (homolog to anthranilate phosphoribosyltransferase). (354 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (438 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (395 aa)
matS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (401 aa)
cysK2Cysteine synthase. (327 aa)
fba22-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (262 aa)
trpATryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate; Belongs to the TrpA family. (277 aa)
trpB1Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (417 aa)
trpCIndole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (254 aa)
trpD1Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (333 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (208 aa)
trpE1Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (531 aa)
trpG1Anthranilate synthase component 2. (197 aa)
tyrAPrephenate dehydrogenase. (243 aa)
trpB2Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (389 aa)
metE15-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (methionine synthase II); Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. (356 aa)
metE25-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (methionine synthase II). (327 aa)
tpiA2Triosephosphate isomerase. (230 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (257 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (284 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (438 aa)
aroQChorismate mutase. (96 aa)
aroKShikimate kinase, archaeal-type. (280 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (396 aa)
hisFImidazoleglycerol-phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (271 aa)
cysESerine O-acetyltransferase. (189 aa)
glnA2Glutamine synthetase. (451 aa)
aspC3Pyridoxal phosphate-dependent aminotransferase. (382 aa)
thrC2Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (409 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (291 aa)
cysK1Cysteine synthase. (329 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (593 aa)
ilvE1Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (312 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (120 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (400 aa)
argHArgininosuccinate lyase. (490 aa)
argXPutative glutamate--argW ligase. (287 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (346 aa)
argBAcetylglutamate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (277 aa)
argDAcetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (375 aa)
argEAcetylornithine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (349 aa)
argFOrnithine carbamoyltransferase. (294 aa)
thrC1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (419 aa)
Your Current Organism:
Natronomonas pharaonis
NCBI taxonomy Id: 348780
Other names: N. pharaonis DSM 2160, Natronomonas pharaonis ATCC 35678, Natronomonas pharaonis DSM 2160, Natronomonas pharaonis Gabara, Natronomonas pharaonis JCM 8858, Natronomonas pharaonis str. DSM 2160, Natronomonas pharaonis strain DSM 2160
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