node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PV05_00114 | PV05_00162 | A0A0D2EVU6 | A0A0D2EZ01 | Uncharacterized protein. | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. | 0.742 |
PV05_00114 | PV05_00447 | A0A0D2EVU6 | A0A0D2DD23 | Uncharacterized protein. | Uncharacterized protein; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.537 |
PV05_00114 | PV05_00728 | A0A0D2EVU6 | A0A0D2C6N6 | Uncharacterized protein. | Uncharacterized protein. | 0.811 |
PV05_00114 | PV05_00917 | A0A0D2EVU6 | A0A0D2F191 | Uncharacterized protein. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.763 |
PV05_00114 | PV05_01284 | A0A0D2EVU6 | A0A0D2C868 | Uncharacterized protein. | Histone H2B; Belongs to the histone H2B family. | 0.649 |
PV05_00114 | PV05_01879 | A0A0D2EVU6 | A0A0D2F1H0 | Uncharacterized protein. | Uncharacterized protein. | 0.716 |
PV05_00114 | PV05_05079 | A0A0D2EVU6 | A0A0D2F8Q2 | Uncharacterized protein. | Polyubiquitin. | 0.826 |
PV05_00114 | PV05_07520 | A0A0D2EVU6 | A0A0D2CYJ9 | Uncharacterized protein. | AAA_23 domain-containing protein. | 0.697 |
PV05_00114 | PV05_09061 | A0A0D2EVU6 | A0A0D2BLT8 | Uncharacterized protein. | BZIP domain-containing protein. | 0.811 |
PV05_00114 | PV05_09373 | A0A0D2EVU6 | A0A0D2ERZ6 | Uncharacterized protein. | Ubiquitin-40S ribosomal protein S27a. | 0.811 |
PV05_00114 | PV05_10103 | A0A0D2EVU6 | A0A0D2E7E3 | Uncharacterized protein. | Uncharacterized protein. | 0.716 |
PV05_00162 | PV05_00114 | A0A0D2EZ01 | A0A0D2EVU6 | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. | Uncharacterized protein. | 0.742 |
PV05_00162 | PV05_00447 | A0A0D2EZ01 | A0A0D2DD23 | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. | Uncharacterized protein; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.763 |
PV05_00162 | PV05_00822 | A0A0D2EZ01 | A0A0D2EY24 | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.825 |
PV05_00162 | PV05_00917 | A0A0D2EZ01 | A0A0D2F191 | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.991 |
PV05_00162 | PV05_01284 | A0A0D2EZ01 | A0A0D2C868 | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. | Histone H2B; Belongs to the histone H2B family. | 0.633 |
PV05_00162 | PV05_01879 | A0A0D2EZ01 | A0A0D2F1H0 | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. | Uncharacterized protein. | 0.972 |
PV05_00162 | PV05_05079 | A0A0D2EZ01 | A0A0D2F8Q2 | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. | Polyubiquitin. | 0.674 |
PV05_00162 | PV05_07520 | A0A0D2EZ01 | A0A0D2CYJ9 | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. | AAA_23 domain-containing protein. | 0.986 |
PV05_00162 | PV05_10103 | A0A0D2EZ01 | A0A0D2E7E3 | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. | Uncharacterized protein. | 0.954 |