(30 nodes) Terpenoid backbone biosynthesis network (Exophiala xenobiotica)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	PV05_10834	Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (286 aa)
	PV05_10749	Uncharacterized protein. (423 aa)
	PV05_02095	Uncharacterized protein. (253 aa)
	PV05_01708	Uncharacterized protein. (621 aa)
	PV05_00843	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (485 aa)
	PV05_00554	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (472 aa)
	PV05_03552	Di-trans,poly-cis-decaprenylcistransferase. (409 aa)
	PV05_02484	Uncharacterized protein. (328 aa)
	PV05_09481	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (471 aa)
	PV05_09459	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (564 aa)
	PV05_00208	Isopentenyl-diphosphate delta-isomerase. (281 aa)
	PV05_08958	Uncharacterized protein. (596 aa)
	PV05_09042	AB hydrolase-1 domain-containing protein. (573 aa)
	PV05_01505	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (460 aa)
	PV05_01551	Prenylcys_lyase domain-containing protein. (483 aa)
	PV05_05172	Uncharacterized protein. (374 aa)
	PV05_01256	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (851 aa)
	PV05_08959	Uncharacterized protein. (830 aa)
	PV05_08918	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (438 aa)
	PV05_04269	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (466 aa)
	PV05_07567	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1007 aa)
	PV05_05107	Uncharacterized protein. (471 aa)
	PV05_11505	Peptidase_M48 domain-containing protein. (365 aa)
	PV05_03749	Uncharacterized protein. (421 aa)
	PV05_07603	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1146 aa)
	PV05_08375	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (398 aa)
	PV05_02195	Farnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (348 aa)
	PV05_06504	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (386 aa)
	PV05_10096	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (413 aa)
	PV05_09460	Uncharacterized protein. (356 aa)

Your Current Organism:

Exophiala xenobiotica

NCBI taxonomy Id: 348802
Other names: CBS 118157, E. xenobiotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PV05_00208	PV05_00554	A0A0D2EZ57	A0A0D2DDD1	Isopentenyl-diphosphate delta-isomerase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.909
PV05_00208	PV05_00843	A0A0D2EZ57	A0A0D2DEB3	Isopentenyl-diphosphate delta-isomerase.	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.537
PV05_00208	PV05_01505	A0A0D2EZ57	A0A0D2F352	Isopentenyl-diphosphate delta-isomerase.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.459
PV05_00208	PV05_02195	A0A0D2EZ57	A0A0D2BYX2	Isopentenyl-diphosphate delta-isomerase.	Farnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family.	0.920
PV05_00208	PV05_03552	A0A0D2EZ57	A0A0D2EWC8	Isopentenyl-diphosphate delta-isomerase.	Di-trans,poly-cis-decaprenylcistransferase.	0.854
PV05_00208	PV05_04269	A0A0D2EZ57	A0A0D2EJH3	Isopentenyl-diphosphate delta-isomerase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.890
PV05_00208	PV05_05172	A0A0D2EZ57	A0A0D2F943	Isopentenyl-diphosphate delta-isomerase.	Uncharacterized protein.	0.850
PV05_00208	PV05_06504	A0A0D2EZ57	A0A0D2BNG3	Isopentenyl-diphosphate delta-isomerase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.899
PV05_00208	PV05_07603	A0A0D2EZ57	A0A0D2CYU1	Isopentenyl-diphosphate delta-isomerase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.779
PV05_00208	PV05_08375	A0A0D2EZ57	A0A0D2CRW9	Isopentenyl-diphosphate delta-isomerase.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.954
PV05_00208	PV05_09459	A0A0D2EZ57	A0A0D2E7F7	Isopentenyl-diphosphate delta-isomerase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.731
PV05_00208	PV05_10096	A0A0D2EZ57	A0A0D2BGL8	Isopentenyl-diphosphate delta-isomerase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.543
PV05_00554	PV05_00208	A0A0D2DDD1	A0A0D2EZ57	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Isopentenyl-diphosphate delta-isomerase.	0.909
PV05_00554	PV05_00843	A0A0D2DDD1	A0A0D2DEB3	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.544
PV05_00554	PV05_02195	A0A0D2DDD1	A0A0D2BYX2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Farnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family.	0.823
PV05_00554	PV05_03552	A0A0D2DDD1	A0A0D2EWC8	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Di-trans,poly-cis-decaprenylcistransferase.	0.452
PV05_00554	PV05_04269	A0A0D2DDD1	A0A0D2EJH3	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.642
PV05_00554	PV05_05107	A0A0D2DDD1	A0A0D2ELZ4	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.529
PV05_00554	PV05_05172	A0A0D2DDD1	A0A0D2F943	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.455
PV05_00554	PV05_06504	A0A0D2DDD1	A0A0D2BNG3	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.731