STRINGSTRING
Hhal_0142 Hhal_0142 Hhal_0143 Hhal_0143 Hhal_0144 Hhal_0144 Hhal_0145 Hhal_0145 Hhal_0213 Hhal_0213 Hhal_0458 Hhal_0458 Hhal_0459 Hhal_0459 Hhal_0464 Hhal_0464 lon lon clpX clpX clpP clpP Hhal_0662 Hhal_0662 Hhal_0663 Hhal_0663 Hhal_0664 Hhal_0664 hflX hflX hfq hfq miaA miaA Hhal_0669 Hhal_0669 Hhal_0670 Hhal_0670 nnrD nnrD queG queG Hhal_0938 Hhal_0938 Hhal_0943 Hhal_0943 Hhal_1001 Hhal_1001 hslV hslV hslU hslU msrA msrA Hhal_1391 Hhal_1391 Hhal_1400 Hhal_1400 clpS clpS dnaJ dnaJ dnaK dnaK grpE grpE hrcA hrcA nadK nadK Hhal_1480 Hhal_1480 htpG htpG Hhal_1595 Hhal_1595 Hhal_1689 Hhal_1689 ftsH ftsH Hhal_1971 Hhal_1971 htpX htpX Hhal_1997 Hhal_1997 Hhal_2056 Hhal_2056 Hhal_2188 Hhal_2188 clpB clpB Hhal_2289 Hhal_2289 groS groS groL groL Hhal_2396 Hhal_2396
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Hhal_0142Hypothetical protein; KEGG: ade:Adeh_2705 response regulator receiver. (754 aa)
Hhal_0143PFAM: heat shock protein DnaJ domain protein. (113 aa)
Hhal_0144GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (218 aa)
Hhal_0145PFAM: Heat shock protein 70; KEGG: sus:Acid_6320 heat shock protein 70. (577 aa)
Hhal_0213PFAM: glutaredoxin; Glutathione S-transferase, N-terminal domain; KEGG: csa:Csal_3222 glutaredoxin. (118 aa)
Hhal_0458KEGG: aeh:Mlg_1470 hypothetical protein. (234 aa)
Hhal_0459Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (721 aa)
Hhal_0464Heat shock protein Hsp15; PFAM: RNA-binding S4 domain protein; KEGG: aeh:Mlg_1173 RNA-binding S4 domain protein; Belongs to the HSP15 family. (130 aa)
lonATP-dependent proteinase, Serine peptidase, MEROPS family S16; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (820 aa)
clpXATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (426 aa)
clpPATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (210 aa)
Hhal_0662KEGG: tcx:Tcr_1092 hypothetical protein. (63 aa)
Hhal_0663Protease FtsH subunit HflC; HflC and HflK could regulate a protease. (302 aa)
Hhal_0664Protease FtsH subunit HflK; HflC and HflK could encode or regulate a protease. (395 aa)
hflXGTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (445 aa)
hfqRNA-binding protein Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (90 aa)
miaAtRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (310 aa)
Hhal_0669N-acetylmuramoyl-L-alanine amidase; PFAM: Peptidoglycan-binding LysM; cell wall hydrolase/autolysin; KEGG: aeh:Mlg_0570 N-acetylmuramoyl-L-alanine amidase. (430 aa)
Hhal_0670PFAM: protein of unknown function UPF0079; KEGG: sgl:SG0333 hypothetical protein. (155 aa)
nnrDCarbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] (509 aa)
queGPutative iron-sulfur cluster binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (355 aa)
Hhal_0938PFAM: protein of unknown function DUF179; KEGG: aeh:Mlg_0349 protein of unknown function DUF179; Belongs to the UPF0301 (AlgH) family. (192 aa)
Hhal_0943PFAM: Thioredoxin domain; KEGG: aeh:Mlg_0318 thioredoxin. (286 aa)
Hhal_1001Hsp33 protein; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress; Belongs to the HSP33 family. (296 aa)
hslVHslV component of HslUV peptidase, Threonine peptidase, MEROPS family T01B; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (184 aa)
hslUHeat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (442 aa)
msrAPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (180 aa)
Hhal_1391PFAM: protein of unknown function UPF0005; KEGG: aeh:Mlg_1630 protein of unknown function UPF0005; Belongs to the BI1 family. (226 aa)
Hhal_1400KEGG: aeh:Mlg_1447 ATP-dependent Clp protease, ATP-binding subunit ClpA; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. (756 aa)
clpSATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (106 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (385 aa)
dnaKChaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (647 aa)
grpEGrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (240 aa)
hrcAHeat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (351 aa)
nadKNAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (307 aa)
Hhal_1480DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA. (556 aa)
htpGHeat shock protein Hsp90; Molecular chaperone. Has ATPase activity. (633 aa)
Hhal_1595KEGG: aeh:Mlg_2039 methionine-R-sulfoxide reductase; TIGRFAM: methionine-R-sulfoxide reductase; PFAM: Methionine sulfoxide reductase B; Belongs to the MsrB Met sulfoxide reductase family. (134 aa)
Hhal_1689TIGRFAM: Glutaredoxin-family domain protein; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; glutaredoxin; Redoxin domain protein; KEGG: aeh:Mlg_2464 glutaredoxin-family domain protein. (248 aa)
ftsHMembrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (651 aa)
Hhal_1971PFAM: glutaredoxin; KEGG: aeh:Mlg_0529 glutaredoxin. (253 aa)
htpXHeat shock protein, Metallo peptidase, MEROPS family M48B; PFAM: peptidase M48, Ste24p; HtpX domain protein; KEGG: aeh:Mlg_0715 HtpX domain protein; Belongs to the peptidase M48B family. (297 aa)
Hhal_1997Plasmid segregation actin-type ATPase ParM; KEGG: sth:STH3287 hypothetical protein. (384 aa)
Hhal_2056TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: aeh:Mlg_0368 thioredoxin; Belongs to the thioredoxin family. (108 aa)
Hhal_2188PFAM: heat shock protein Hsp20; KEGG: aeh:Mlg_0320 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family. (156 aa)
clpBATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (870 aa)
Hhal_2289TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: aeh:Mlg_0248 thioredoxin reductase. (320 aa)
groSChaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (96 aa)
groLChaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (550 aa)
Hhal_2396TIGRFAM: glutathione-disulfide reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: aeh:Mlg_2534 glutathione-disulfide reductase. (453 aa)
Your Current Organism:
Halorhodospira halophila
NCBI taxonomy Id: 349124
Other names: H. halophila SL1, Halorhodospira halophila DSM 244, Halorhodospira halophila SL 1, Halorhodospira halophila SL1, Halorhodospira halophila str. SL1, Halorhodospira halophila strain SL1
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