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nusA nusA Mthe_0047 Mthe_0047 Mthe_0064 Mthe_0064 Mthe_0065 Mthe_0065 Mthe_0137 Mthe_0137 Mthe_0151 Mthe_0151 tbp tbp eif1a eif1a eif2b eif2b Mthe_0187 Mthe_0187 tfb tfb Mthe_0286 Mthe_0286 Mthe_0289 Mthe_0289 prf1 prf1 Mthe_0366 Mthe_0366 Mthe_0384 Mthe_0384 Mthe_0407 Mthe_0407 Mthe_0416 Mthe_0416 Mthe_0436 Mthe_0436 Mthe_0449 Mthe_0449 Mthe_0457 Mthe_0457 Mthe_0459 Mthe_0459 Mthe_0477 Mthe_0477 Mthe_0484 Mthe_0484 Mthe_0503 Mthe_0503 Mthe_0511 Mthe_0511 Mthe_0543 Mthe_0543 Mthe_0581 Mthe_0581 Mthe_0584 Mthe_0584 Mthe_0598 Mthe_0598 Mthe_0612 Mthe_0612 Mthe_0620 Mthe_0620 Mthe_0621 Mthe_0621 Mthe_0630 Mthe_0630 Mthe_0662 Mthe_0662 Mthe_0674 Mthe_0674 Mthe_0683 Mthe_0683 Mthe_0716 Mthe_0716 Mthe_0793 Mthe_0793 Mthe_0804 Mthe_0804 fusA fusA tuf tuf ef1b ef1b Mthe_0868 Mthe_0868 Mthe_0902 Mthe_0902 Mthe_0903 Mthe_0903 Mthe_1000 Mthe_1000 Mthe_1007 Mthe_1007 Mthe_1026 Mthe_1026 pcn pcn Mthe_1108 Mthe_1108 dphB dphB Mthe_1134 Mthe_1134 Mthe_1153 Mthe_1153 Mthe_1201 Mthe_1201 Mthe_1210 Mthe_1210 Mthe_1230 Mthe_1230 Mthe_1233 Mthe_1233 Mthe_1248 Mthe_1248 Mthe_1291 Mthe_1291 infB infB Mthe_1313 Mthe_1313 eif2g eif2g spt4 spt4 Mthe_1335 Mthe_1335 Mthe_1352 Mthe_1352 Mthe_1376 Mthe_1376 Mthe_1398 Mthe_1398 Mthe_1410 Mthe_1410 rpl1 rpl1 spt5 spt5 Mthe_1431 Mthe_1431 Mthe_1446 Mthe_1446 Mthe_1493 Mthe_1493 Mthe_1517 Mthe_1517 Mthe_1524 Mthe_1524 Mthe_1531 Mthe_1531 eif6 eif6 Mthe_1635 Mthe_1635 tfe tfe eIF5A eIF5A Mthe_1687 Mthe_1687 Mthe_1698 Mthe_1698
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
nusANusA family KH domain protein; Participates in transcription termination. Belongs to the NusA family. (143 aa)
Mthe_0047SMART: regulatory protein, AsnC/Lrp family; KEGG: mba:Mbar_A1460 heme d1 biosynthesis protein NirH. (162 aa)
Mthe_0064PFAM: response regulator receiver; KEGG: gme:Gmet_3211 response regulator receiver domain protein (CheY-like). (119 aa)
Mthe_0065KEGG: mbu:Mbur_0694 external sensor signal transduction histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; PAS fold-4 domain protein; SMART: PAS domain containing protein. (377 aa)
Mthe_0137KEGG: mma:MM2384 hypothetical protein. (122 aa)
Mthe_0151KEGG: mac:MA1281 hypothetical protein. (305 aa)
tbpTATA binding protein of transcription factor TFIID; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (183 aa)
eif1aTranslation initiation factor 1A (aeIF-1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (90 aa)
eif2bTranslation initiation factor 2 subunit beta (aeIF-2b); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (208 aa)
Mthe_0187KEGG: afu:AF1663 hypothetical protein. (88 aa)
tfbTranscription initiation factor IIB (TFIIB); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (337 aa)
Mthe_0286TIGRFAM: uncharacterized domain 1; PFAM: thioesterase superfamily protein; KEGG: mta:Moth_0402 phenylacetic acid degradation protein PaaD. (132 aa)
Mthe_0289PFAM: Cobyrinic acid a,c-diamide synthase; SMART: AAA ATPase; KEGG: mbu:Mbur_0861 cobyrinic acid a,c-diamide synthase. (253 aa)
prf1Peptide chain release factor subunit 1 (aeRF-1); Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (413 aa)
Mthe_0366PFAM: translation initiation factor SUI1; KEGG: mba:Mbar_A0534 translation initiation factor SUI1; Belongs to the SUI1 family. (102 aa)
Mthe_0384KEGG: cyb:CYB_1640 sensory box histidine kinase/response regulator; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; GAF domain protein; ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; Hpt domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein. (1692 aa)
Mthe_0407PFAM: response regulator receiver; KEGG: rru:Rru_A1654 response regulator receiver domain protein (CheY). (142 aa)
Mthe_0416PFAM: RNA binding S1 domain protein; Eukaryotic translation initiation factor 2, alpha subunit; KEGG: mbu:Mbur_1396 translation initiation factor 2, alpha subunit. (257 aa)
Mthe_0436Putative transcriptional regulator, CopG/Arc/MetJ family; KEGG: mba:Mbar_A1024 hypothetical protein. (55 aa)
Mthe_0449Protoporphyrin IX magnesium-chelatase; KEGG: mhu:Mhun_0291 magnesium chelatase, ChlI subunit; PFAM: magnesium chelatase, ChlI subunit; von Willebrand factor, type A; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase. (669 aa)
Mthe_0457PFAM: GvpD gas vesicle; SMART: AAA ATPase; KEGG: hal:VNG6240G GvpD protein, cluster B. (454 aa)
Mthe_0459Transcriptional regulator, XRE family; SMART: helix-turn-helix domain protein; KEGG: mma:MM1005 zinc finger protein. (165 aa)
Mthe_0477PFAM: protein of unknown function DUF52; KEGG: mma:MM1761 conserved protein; Belongs to the MEMO1 family. (269 aa)
Mthe_0484Transcriptional regulator, XRE family; SMART: helix-turn-helix domain protein; KEGG: mbu:Mbur_0290 hypothetical protein. (116 aa)
Mthe_0503PFAM: regulatory protein, AsnC/Lrp family; KEGG: mac:MA1588 hypothetical protein. (77 aa)
Mthe_0511PFAM: Cobyrinic acid a,c-diamide synthase; KEGG: mac:MA3449 hypothetical protein. (249 aa)
Mthe_0543PFAM: CopG domain protein DNA-binding domain protein; KEGG: afu:AF1745 hypothetical protein. (180 aa)
Mthe_0581PFAM: deoxyribonuclease/rho motif-related TRAM; KEGG: mbu:Mbur_0304 hypothetical protein. (74 aa)
Mthe_0584PFAM: transcriptional regulator TrmB; KEGG: mbu:Mbur_1199 hypothetical protein. (355 aa)
Mthe_0598PFAM: regulatory protein, AsnC/Lrp family; KEGG: mac:MA1588 hypothetical protein. (76 aa)
Mthe_0612PFAM: regulatory protein, ArsR; KEGG: mma:MM1257 transcriptional regulator, ArsR family. (204 aa)
Mthe_0620Phosphate uptake regulator, PhoU; PFAM: SpoVT/AbrB domain protein; PhoU family protein; KEGG: mac:MA1380 hypothetical protein. (336 aa)
Mthe_0621Phosphate uptake regulator, PhoU; Plays a role in the regulation of phosphate uptake. (226 aa)
Mthe_0630Multi-sensor signal transduction histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; PAS fold-4 domain protein; PAS fold domain protein; KEGG: noc:Noc_2450 PAS sensor signal transduction histidine kinase. (713 aa)
Mthe_0662Transcriptional regulator, CopG family; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (140 aa)
Mthe_06742'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. (177 aa)
Mthe_0683PFAM: Fe-S cluster domain protein; KEGG: mbu:Mbur_1457 putative Fe-S cluster protein. (203 aa)
Mthe_0716KaiC; KEGG: mbu:Mbur_1808 KaiC. (208 aa)
Mthe_0793biotin--acetyl-CoA-carboxylase ligase; KEGG: mma:MM1829 biotin--[acetyl-COA-carboxylase] synthetase; TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin protein ligase domain protein; biotin/lipoate A/B protein ligase; Helix-turn-helix, type 11 domain protein. (336 aa)
Mthe_0804KEGG: mba:Mbar_A1639 hypothetical protein. (119 aa)
fusATranslation elongation factor 2 (EF-2/EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...] (730 aa)
tufTranslation elongation factor 1A (EF-1A/EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (424 aa)
ef1bTranslation elongation factor 1B (aEF-1B); Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (89 aa)
Mthe_0868KEGG: pfu:PF0263 hypothetical protein; Belongs to the GbsR family. (192 aa)
Mthe_0902KEGG: afu:AF1663 hypothetical protein. (83 aa)
Mthe_0903Dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: mac:MA1652 dihydrolipoamide dehydrogenase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (462 aa)
Mthe_1000PFAM: histone deacetylase superfamily; KEGG: sat:SYN_01017 deacetylase family protrein. (252 aa)
Mthe_1007Transcriptional regulator, ArsR family; PFAM: Domain of unknown function DUF1724; KEGG: mth:MTH1843 hypothetical protein. (269 aa)
Mthe_1026PFAM: Transcription factor TFIIS; KEGG: mma:MM1398 DNA-directed RNA polymerase subunit M. (85 aa)
pcnMonomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. (244 aa)
Mthe_1108Transcriptional regulator, ArsR family; PFAM: regulatory protein, ArsR; KEGG: dsy:DSY4143 hypothetical protein. (127 aa)
dphBDiphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. (265 aa)
Mthe_1134SMART: regulatory protein, AsnC/Lrp family; KEGG: mbu:Mbur_1232 transcriptional regulator, AsnC family. (149 aa)
Mthe_1153Putative signal transduction protein with CBS domains; PFAM: CBS domain containing protein; protein of unknown function UPF0074; Protein of unknown function DUF293; Helix-turn-helix, type 11 domain protein; KEGG: mac:MA1391 hypothetical protein. (288 aa)
Mthe_1201PFAM: sigma-70 region 4 domain protein; KEGG: mja:MJ0173 hypothetical protein. (146 aa)
Mthe_1210Putative transcriptional regulator; PFAM: AAA-4 family protein; KEGG: mac:MA2370 ATP-dependent DNA helicase. (448 aa)
Mthe_1230Transcriptional regulator, ArsR family; PFAM: regulatory protein, ArsR; KEGG: pho:PH0885 hypothetical protein. (107 aa)
Mthe_1233PFAM: Helix-turn-helix, type 11 domain protein; SMART: regulatory protein, Crp; KEGG: mma:MM0289 transcriptional regulator. (264 aa)
Mthe_1248PFAM: response regulator receiver; KEGG: noc:Noc_2451 response regulator receiver. (157 aa)
Mthe_1291PFAM: regulatory protein, ArsR; KEGG: mma:MM2246 transcriptional regulator, ArsR family. (121 aa)
infBTranslation initiation factor eaIF-5B; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. (602 aa)
Mthe_1313KEGG: mba:Mbar_A2256 CODH nickel-insertion accessory protein. (213 aa)
eif2gTranslation initiation factor 2 subunit gamma (aeIF-2g); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (409 aa)
spt4DNA-directed RNA polymerase, subunit E; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. (61 aa)
Mthe_1335Serine phosphatase; PFAM: histidine kinase, HAMP region domain protein; Stage II sporulation E family protein; SMART: protein phosphatase 2C domain protein; KEGG: mhu:Mhun_0060 serine phosphatase. (636 aa)
Mthe_1352TIGRFAM: putative ATP binding protein; PFAM: protein of unknown function DUF71, ATP-binding region; KEGG: mhu:Mhun_1584 protein of unknown function DUF71, ATP-binding region. (238 aa)
Mthe_1376PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: dme:CG6915-PA CG6915 gene product from transcript CG6915-RA. (1261 aa)
Mthe_1398PFAM: elongation factor Tu, domain 2 protein; KEGG: mhu:Mhun_2296 elongation factor Tu, domain 2. (316 aa)
Mthe_1410PFAM: multiple antibiotic resistance (MarC)-related proteins; KEGG: mba:Mbar_A3711 multiple antibiotic resistance protein. (231 aa)
rpl1LSU ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (212 aa)
spt5LSU ribosomal protein L24A; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (153 aa)
Mthe_1431PFAM: deoxyribonuclease/rho motif-related TRAM; KEGG: mbu:Mbur_0304 hypothetical protein. (74 aa)
Mthe_1446Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; KEGG: mba:Mbar_A2318 hypothetical protein. (334 aa)
Mthe_1493KEGG: gme:Gmet_0666 PAS/PAC sensor signal transduction histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein. (761 aa)
Mthe_1517Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: noc:Noc_2450 PAS sensor signal transduction histidine kinase. (607 aa)
Mthe_1524Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: noc:Noc_2450 PAS sensor signal transduction histidine kinase. (607 aa)
Mthe_1531Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: noc:Noc_2450 PAS sensor signal transduction histidine kinase. (607 aa)
eif6Translation initiation factor 6 (aeIF-6); Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (221 aa)
Mthe_1635Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. (334 aa)
tfeTranscription factor IIE (TFIIE), alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elo [...] (167 aa)
eIF5ATranslation initiation factor 5A precursor (eIF-5A); Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (127 aa)
Mthe_1687TIGRFAM: PAS sensor protein; KEGG: gsu:GSU2789 sensory box histidine kinase. (183 aa)
Mthe_1698KEGG: mhu:Mhun_2616 hypothetical protein. (187 aa)
Your Current Organism:
Methanothrix thermoacetophila
NCBI taxonomy Id: 349307
Other names: M. thermoacetophila PT, Methanosaeta thermophila PT, Methanothrix thermoacetophila PT, Methanothrix thermophila DSM 6194, Methanothrix thermophila PT
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