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Mthe_1082 Mthe_1082 mutS2 mutS2 Mthe_0986 Mthe_0986 radB radB Mthe_0911 Mthe_0911 Mthe_0886 Mthe_0886 radA radA lig lig hel308 hel308 Mthe_0782 Mthe_0782 Mthe_0779 Mthe_0779 Mthe_0743 Mthe_0743 Mthe_0742 Mthe_0742 Mthe_0737 Mthe_0737 dnaJ dnaJ Mthe_0728 Mthe_0728 Mthe_0711 Mthe_0711 Mthe_0707 Mthe_0707 Mthe_0685 Mthe_0685 Mthe_0662 Mthe_0662 Mthe_0651 Mthe_0651 Mthe_0650 Mthe_0650 Mthe_0649 Mthe_0649 Mthe_0648 Mthe_0648 Mthe_0647 Mthe_0647 Mthe_0646 Mthe_0646 Mthe_0645 Mthe_0645 Mthe_0644 Mthe_0644 Mthe_0641 Mthe_0641 Mthe_0640 Mthe_0640 Mthe_0637 Mthe_0637 cas2 cas2 Mthe_0633 Mthe_0633 Mthe_0630 Mthe_0630 Mthe_0534 Mthe_0534 Mthe_0533 Mthe_0533 Mthe_0493 Mthe_0493 Mthe_0013 Mthe_0013 Mthe_0011 Mthe_0011 Mthe_0237 Mthe_0237 Mthe_0228 Mthe_0228 Mthe_0199 Mthe_0199 Mthe_0094 Mthe_0094 Mthe_0065 Mthe_0065 Mthe_0064 Mthe_0064 Mthe_1692 Mthe_1692 Mthe_1687 Mthe_1687 Mthe_1653 Mthe_1653 fen fen Mthe_1631 Mthe_1631 Mthe_1589 Mthe_1589 cas2-2 cas2-2 cas1 cas1 Mthe_1558 Mthe_1558 Mthe_1531 Mthe_1531 Mthe_1524 Mthe_1524 Mthe_1517 Mthe_1517 Mthe_1484 Mthe_1484 Mthe_1483 Mthe_1483 Mthe_1479 Mthe_1479 mutL mutL mutS mutS Mthe_1472 Mthe_1472 Mthe_1443 Mthe_1443 Mthe_1437 Mthe_1437 Mthe_1429 Mthe_1429 Mthe_1416 Mthe_1416 Mthe_1341 Mthe_1341 Mthe_1335 Mthe_1335 Mthe_1315 Mthe_1315 Mthe_1281 Mthe_1281 nfi nfi Mthe_1248 Mthe_1248 Mthe_1232 Mthe_1232 Mthe_0251 Mthe_0251 Mthe_1216 Mthe_1216 Mthe_0260 Mthe_0260 Mthe_0316 Mthe_0316 Mthe_0319 Mthe_0319 Mthe_0361 Mthe_0361 Mthe_0384 Mthe_0384 nfo nfo Mthe_0407 Mthe_0407 Mthe_0471 Mthe_0471 Mthe_1207 Mthe_1207 Mthe_1150 Mthe_1150 Mthe_1133 Mthe_1133
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Mthe_1082PFAM: conserved hypothetical protein 374; KEGG: bja:bll5419 hypothetical protein. (304 aa)
mutS2DNA mismatch repair protein, MutS family; Has ATPase and non-specific DNA-binding activities. Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily. (678 aa)
Mthe_0986PFAM: DNA ligase domain protein; ATP dependent DNA ligase; KEGG: pai:PAE0833 DNA ligase. (385 aa)
radBDNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. (221 aa)
Mthe_0911PFAM: HhH-GPD family protein; SMART: iron-sulfur cluster loop; KEGG: cya:CYA_0846 base excision DNA repair protein, HhH-GPD family. (219 aa)
Mthe_0886PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mbu:Mbur_1764 single-stranded DNA-binding replication protein A (RPA) large (70 kD) subunit and related ssDNA-binding proteins. (371 aa)
radADNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (322 aa)
ligDNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (552 aa)
hel308DEAD/DEAH box helicase domain protein; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (693 aa)
Mthe_0782TIGRFAM: alkylhydroperoxidase like protein, AhpD family; PFAM: Carboxymuconolactone decarboxylase; KEGG: mth:MTH935 hypothetical protein. (107 aa)
Mthe_0779ATP dependent helicase, Lhr family; PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; DEAD/H associated domain protein; SMART: DEAD-like helicases-like; KEGG: mbu:Mbur_0732 DEAD/DEAH box helicase-like protein. (932 aa)
Mthe_0743PFAM: Rubrerythrin; Rubredoxin-type Fe(Cys)4 protein; KEGG: sat:SYN_00469 rubrerythrin. (165 aa)
Mthe_0742Nucleoid protein MC1; PFAM: Non-histone chromosomal MC1; KEGG: mma:MM1221 chromosomal protein. (94 aa)
Mthe_0737KEGG: mbu:Mbur_1930 hypothetical protein. (244 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (386 aa)
Mthe_0728CRISPR-associated exonuclease, Cas4 family; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (172 aa)
Mthe_0711TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: mbu:Mbur_1670 thioredoxin. (138 aa)
Mthe_0707PFAM: glutaredoxin; glutaredoxin 2; KEGG: mba:Mbar_A1038 glutaredoxin-like protein. (81 aa)
Mthe_0685Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (208 aa)
Mthe_0662Transcriptional regulator, CopG family; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (140 aa)
Mthe_0651TIGRFAM: CRISPR-associated protein, TM1812 family; CRISPR-associated protein DxTHG motif; KEGG: tma:TM1812 hypothetical protein. (583 aa)
Mthe_0650TIGRFAM: CRISPR-associated RAMP protein, Cmr1 family; PFAM: protein of unknown function DUF324; KEGG: sat:SYN_02252 hypothetical cytosolic protein. (421 aa)
Mthe_0649TIGRFAM: CRISPR-associated protein, Crm2 family; KEGG: tte:TTE2639 predicted hydrolase of the HD superfamily (permuted catalytic motifs). (638 aa)
Mthe_0648TIGRFAM: CRISPR-associated protein, Cmr3 family; KEGG: ttj:TTHB161 hypothetical protein. (358 aa)
Mthe_0647TIGRFAM: CRISPR-associated RAMP protein, Cmr4 family; PFAM: protein of unknown function DUF324; KEGG: dge:Dgeo_0962 CRISPR-associated RAMP Cmr4. (267 aa)
Mthe_0646TIGRFAM: CRISPR-associated protein, Cmr5 family; KEGG: sat:SYN_02248 hypothetical cytosolic protein. (133 aa)
Mthe_0645TIGRFAM: CRISPR-associated RAMP protein, Cmr6 family; PFAM: protein of unknown function DUF324; KEGG: sat:SYN_02247 hypothetical cytosolic protein. (341 aa)
Mthe_0644KEGG: ppr:PBPRA1222 hypothetical protein. (404 aa)
Mthe_0641TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated HD domain protein; SMART: DEAD-like helicases-like; KEGG: mst:Msp_0422 predicted helicase. (804 aa)
Mthe_0640CRISPR-associated protein, Cas5h family; TIGRFAM: CRISPR-associated protein Cas5, Hmari subtype; CRISPR-associated protein Cas5; KEGG: mst:Msp_0421 hypothetical protein. (233 aa)
Mthe_0637CRISPR-associated exonuclease, Cas4 family; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (191 aa)
cas2CRISPR-associated protein, Cas2 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (95 aa)
Mthe_0633PFAM: AMP-dependent synthetase and ligase; KEGG: mbu:Mbur_0339 phenylacetate--CoA ligase. (432 aa)
Mthe_0630Multi-sensor signal transduction histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; PAS fold-4 domain protein; PAS fold domain protein; KEGG: noc:Noc_2450 PAS sensor signal transduction histidine kinase. (713 aa)
Mthe_0534TIGRFAM: phosphoesterase, putative; KEGG: mmp:MMP1142 metallo-phosphoesterase:serine/threonine-specific protein phosphatase. (235 aa)
Mthe_0533ATP dependent helicase, Lhr family; PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; DEAD/H associated domain protein; SMART: DEAD-like helicases-like; KEGG: mmp:MMP1141 Lhr-like RNA helicase. (870 aa)
Mthe_0493TIGRFAM: alkylhydroperoxidase like protein, AhpD family; PFAM: Carboxymuconolactone decarboxylase; KEGG: mbu:Mbur_1909 alkylhydroperoxidase like protein. (145 aa)
Mthe_0013phenylacetate-CoA ligase; KEGG: afu:AF1070 coenzyme F390 synthetase (FtsA-1). (427 aa)
Mthe_0011PFAM: CutA1 divalent ion tolerance protein; KEGG: ape:APE1668 106aa long hypothetical periplasmic divalent cation tolerance protein. (105 aa)
Mthe_0237Deoxyribodipyrimidine photolyase-like protein; KEGG: mac:MA4066 deoxyribodipyrimidine photolyase. (114 aa)
Mthe_0228PFAM: helix-hairpin-helix motif; helicase domain protein; ERCC4 domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; SMART: Helix-hairpin-helix DNA-binding, class 1; DEAD-like helicases-like; KEGG: afu:AF1458 ATP-dependent RNA helicase, putative. (749 aa)
Mthe_0199Protein of unknown function DUF650; Involved in DNA damage repair; Belongs to the Nre family. (398 aa)
Mthe_0094PFAM: Carboxymuconolactone decarboxylase; KEGG: mac:MA3736 carboxymuconolactone decarboxylase. (125 aa)
Mthe_0065KEGG: mbu:Mbur_0694 external sensor signal transduction histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; PAS fold-4 domain protein; SMART: PAS domain containing protein. (377 aa)
Mthe_0064PFAM: response regulator receiver; KEGG: gme:Gmet_3211 response regulator receiver domain protein (CheY-like). (119 aa)
Mthe_1692PFAM: conserved hypothetical protein 374; KEGG: mst:Msp_1503 conserved hypothetical membrane-spanning protein. (385 aa)
Mthe_1687TIGRFAM: PAS sensor protein; KEGG: gsu:GSU2789 sensory box histidine kinase. (183 aa)
Mthe_1653PFAM: protein of unknown function DUF541; KEGG: rsp:RSP_2430 hypothetical protein. (233 aa)
fenFlap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] (336 aa)
Mthe_1631PFAM: heat shock protein Hsp20; CS; KEGG: bja:blr7961 probable HspC2 heat shock protein; Belongs to the small heat shock protein (HSP20) family. (145 aa)
Mthe_1589TIGRFAM: methylated-DNA--protein-cysteine methyltransferase; PFAM: methylated-DNA-[protein]-cysteine S-methyltransferase; KEGG: det:DET1460 methylated-DNA--protein-cysteine methyltransferase. (140 aa)
cas2-2CRISPR-associated protein, Cas2 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (88 aa)
cas1CRISPR-associated protein, Cas1 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (330 aa)
Mthe_1558CRISPR-associated exonuclease, Cas4 family; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (190 aa)
Mthe_1531Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: noc:Noc_2450 PAS sensor signal transduction histidine kinase. (607 aa)
Mthe_1524Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: noc:Noc_2450 PAS sensor signal transduction histidine kinase. (607 aa)
Mthe_1517Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: noc:Noc_2450 PAS sensor signal transduction histidine kinase. (607 aa)
Mthe_1484PFAM: SMC domain protein; KEGG: mst:Msp_1095 DNA double-strand break repair protein Rad50. (1061 aa)
Mthe_1483PFAM: metallophosphoesterase; KEGG: mst:Msp_1094 DNA double-strand break repair protein Mre11. (375 aa)
Mthe_1479TIGRFAM: phage SPO1 DNA polymerase-related protein; PFAM: Uracil-DNA glycosylase superfamily; KEGG: ape:APE0427 DNA polymerase homologus protein. (184 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (557 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (857 aa)
Mthe_1472PFAM: Integral membrane protein TerC; KEGG: gvi:glr4409 putative transmembrane transport protein. (318 aa)
Mthe_1443KEGG: mbu:Mbur_1362 single-stranded DNA-binding replication protein A. (405 aa)
Mthe_1437TIGRFAM: ZPR1-like zinc finger protein; ZPR1-related zinc finger protein; PFAM: Zinc finger, ZPR1-type; KEGG: mbu:Mbur_0189 ZPR1-like zinc finger protein. (191 aa)
Mthe_1429Methyltransferase type 11; PFAM: UbiE/COQ5 methyltransferase; Methyltransferase type 11; Methyltransferase type 12; KEGG: mma:MM0661 methyltransferase. (262 aa)
Mthe_14161-Cys peroxiredoxin / 3-Cys thioredoxin peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (220 aa)
Mthe_1341KEGG: mma:MM0121 carbon monoxide dehydrogenase; TIGRFAM: carbon-monoxide dehydrogenase, catalytic subunit; PFAM: Prismane. (623 aa)
Mthe_1335Serine phosphatase; PFAM: histidine kinase, HAMP region domain protein; Stage II sporulation E family protein; SMART: protein phosphatase 2C domain protein; KEGG: mhu:Mhun_0060 serine phosphatase. (636 aa)
Mthe_1315PFAM: helix-hairpin-helix motif; PHP C-terminal domain protein; SMART: DNA polymerase X; phosphoesterase PHP domain protein; Helix-hairpin-helix DNA-binding, class 1; KEGG: sat:SYN_00286 DNA polymerase IV. (588 aa)
Mthe_1281PFAM: Radical SAM domain protein; KEGG: afu:AF0902 hypothetical protein. (294 aa)
nfiDeoxyribonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (223 aa)
Mthe_1248PFAM: response regulator receiver; KEGG: noc:Noc_2451 response regulator receiver. (157 aa)
Mthe_1232PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like; KEGG: mac:MA1411 ATP-dependent DNA helicase. (820 aa)
Mthe_0251PFAM: helix-hairpin-helix motif; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mth:MTH1458 hypothetical protein. (372 aa)
Mthe_1216KEGG: mma:MM2301 carbon monoxide dehydrogenase; TIGRFAM: carbon-monoxide dehydrogenase, catalytic subunit; PFAM: Prismane. (648 aa)
Mthe_0260KEGG: mbu:Mbur_0207 phenylacetate--CoA ligase. (434 aa)
Mthe_0316Hypothetical protein. (340 aa)
Mthe_0319SMART: HhH-GPD family protein; KEGG: fnu:FN0622 8-oxoguanine DNA glycosylase / DNA-(apurinic or apyrimidinic site) lyase. (215 aa)
Mthe_0361PFAM: Xylose isomerase domain protein TIM barrel; KEGG: mma:MM1311 hypothetical protein. (253 aa)
Mthe_0384KEGG: cyb:CYB_1640 sensory box histidine kinase/response regulator; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; GAF domain protein; ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; Hpt domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein. (1692 aa)
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (291 aa)
Mthe_0407PFAM: response regulator receiver; KEGG: rru:Rru_A1654 response regulator receiver domain protein (CheY). (142 aa)
Mthe_0471PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding; KEGG: mma:MM2842 5-nitroimidazole antibiotic resistance protein. (142 aa)
Mthe_1207KEGG: mma:MM2976 type I restriction-modification system restriction subunit. (146 aa)
Mthe_1150Thioredoxin-disulfide reductase; PFAM: glucose-inhibited division protein A; HI0933 family protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: mta:Moth_2420 thioredoxin reductase. (299 aa)
Mthe_1133TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: mba:Mbar_A2310 thioredoxin. (98 aa)
Your Current Organism:
Methanothrix thermoacetophila
NCBI taxonomy Id: 349307
Other names: M. thermoacetophila PT, Methanosaeta thermophila PT, Methanothrix thermoacetophila PT, Methanothrix thermophila DSM 6194, Methanothrix thermophila PT
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