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| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (293 aa) |
| | Mflv_0279 | L-aspartate aminotransferase apoenzyme; PFAM: aminotransferase, class I and II; KEGG: mva:Mvan_0618 aminotransferase, class I and II. (422 aa) |
| | ilvD | KEGG: mkm:Mkms_0155 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (589 aa) |
| | Mflv_0532 | PFAM: dihydrodipicolinate synthetase; KEGG: mva:Mvan_0558 dihydrodipicolinate synthetase; Belongs to the DapA family. (325 aa) |
| | Mflv_0569 | PFAM: aldehyde dehydrogenase; KEGG: mkm:Mkms_1663 aldehyde dehydrogenase (NAD(+)); Belongs to the aldehyde dehydrogenase family. (486 aa) |
| | Mflv_0585 | PFAM: dihydrodipicolinate synthetase; KEGG: mva:Mvan_0472 dihydrodipicolinate synthetase; Belongs to the DapA family. (341 aa) |
| | Mflv_0586 | KEGG: mkm:Mkms_1657 conserved hypothetical protein. (128 aa) |
| | Mflv_0588 | PFAM: dihydrodipicolinate synthetase; KEGG: mva:Mvan_0469 dihydrodipicolinate synthetase; Belongs to the DapA family. (332 aa) |
| | Mflv_0589 | 1-hydroxy-2-naphthoate dioxygenase / gentisate 1,2-dioxygenase; PFAM: Cupin domain protein; Cupin 2, conserved barrel domain protein; KEGG: mva:Mvan_0468 cupin 2, conserved barrel domain protein. (361 aa) |
| | Mflv_0673 | PFAM: dihydrodipicolinate synthetase; KEGG: mva:Mvan_0472 dihydrodipicolinate synthetase. (341 aa) |
| | Mflv_0813 | Anthranilate synthase, component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: mva:Mvan_0022 glutamine amidotransferase of anthranilate synthase. (234 aa) |
| | Mflv_0819 | KEGG: sma:SAV2776 putative L-serine dehydratase; TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (452 aa) |
| | Mflv_0867 | PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase, GAPDH domain protein; KEGG: mva:Mvan_6040 myo-inositol-1-phosphate synthase. (362 aa) |
| | pheA | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: mva:Mvan_5662 prephenate dehydratase. (309 aa) |
| | pat | Aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (360 aa) |
| | Mflv_1212 | PFAM: Prephenate dehydrogenase; KEGG: mva:Mvan_5596 prephenate dehydrogenase. (314 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (606 aa) |
| | Mflv_1303 | PFAM: nitroreductase; KEGG: mva:Mvan_5505 nitroreductase. (199 aa) |
| | Mflv_1304 | KEGG: mva:Mvan_5504 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (440 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (347 aa) |
| | Mflv_1306 | KEGG: mva:Mvan_5502 conserved hypothetical protein. (370 aa) |
| | Mflv_1307 | KEGG: mva:Mvan_5494 conserved hypothetical protein. (132 aa) |
| | Mflv_1545 | PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: mbo:Mb3539c probable acetohydroxyacid synthase IlvX (acetolactate synthase). (531 aa) |
| | Mflv_1673 | Chorismate mutase, putative; Catalyzes the Claisen rearrangement of chorismate to prephenate. (189 aa) |
| | Mflv_1680 | Succinyldiaminopimelate aminotransferase apoenzyme; PFAM: aminotransferase, class I and II; KEGG: mmc:Mmcs_4497 aminotransferase, class I and II. (391 aa) |
| | serC | Aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (395 aa) |
| | Mflv_1860 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; KEGG: mva:Mvan_4874 chorismate mutase. (92 aa) |
| | Mflv_1916 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding, N-terminal domain protein; KEGG: mmc:Mmcs_4283 shikimate 5-dehydrogenase. (298 aa) |
| | Mflv_1926 | TIGRFAM: para-aminobenzoate synthase, subunit I; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: mmc:Mmcs_4272 para-aminobenzoate synthase, component I. (412 aa) |
| | Mflv_2170 | 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (107 aa) |
| | Mflv_2171 | Succinyldiaminopimelate aminotransferase apoenzyme; PFAM: aminotransferase, class I and II; KEGG: mbo:Mb1211 probable aminotransferase. (379 aa) |
| | Mflv_2172 | PFAM: aldehyde dehydrogenase; Proline dehydrogenase; KEGG: art:Arth_3884 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (1140 aa) |
| | dapD | Putative transferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (317 aa) |
| | Mflv_2180 | TIGRFAM: succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: mmc:Mmcs_4012 succinyl-diaminopimelate desuccinylase. (354 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (472 aa) |
| | Mflv_2298 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: mmc:Mmcs_3896 homoserine dehydrogenase. (438 aa) |
| | Mflv_2299 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (359 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (315 aa) |
| | Mflv_2534 | PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: mpa:MAP2330c hypothetical protein. (452 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (370 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (415 aa) |
| | Mflv_2940 | KEGG: mmc:Mmcs_3308 branched-chain amino acid aminotransferase; TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV. (367 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (364 aa) |
| | Mflv_2971 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; KEGG: mmc:Mmcs_3273 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase, class II; Belongs to the class-II DAHP synthase family. (468 aa) |
| | hisE | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mmc:Mmcs_3146 phosphoribosyl-ATP pyrophosphohydrolase. (93 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (281 aa) |
| | Mflv_3175 | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (433 aa) |
| | Mflv_3301 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mmc:Mmcs_2731 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (317 aa) |
| | Mflv_3520 | Hypothetical protein. (168 aa) |
| | Mflv_3521 | KEGG: mva:Mvan_3305 hypothetical protein. (184 aa) |
| | Mflv_3522 | Hypothetical protein. (206 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: mmc:Mmcs_2965 argininosuccinate lyase. (470 aa) |
| | argG | PFAM: argininosuccinate synthase; KEGG: mmc:Mmcs_2966 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (400 aa) |
| | argR | Transcriptional regulator, ArgR family; Regulates arginine biosynthesis genes. (161 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (307 aa) |
| | argD | Aminotransferase; TIGRFAM: acetylornithine and succinylornithine aminotransferases; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class-III; KEGG: mmc:Mmcs_2969 acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (395 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (290 aa) |
| | argJ | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (398 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (349 aa) |
| | Mflv_3531 | PFAM: FAD dependent oxidoreductase; KEGG: fra:Francci3_1888 FAD dependent oxidoreductase. (406 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (262 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (420 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: mmc:Mmcs_3051 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (272 aa) |
| | trpE | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (508 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (115 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (261 aa) |
| | Mflv_3608 | PFAM: inositol monophosphatase; KEGG: mmc:Mmcs_3058 inositol monophosphatase. (272 aa) |
| | priA | Bifunctional HisA/TrpF protein; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (248 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (206 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmc:Mmcs_3061 imidazoleglycerol-phosphate dehydratase. (202 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: mmc:Mmcs_3062 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (377 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (449 aa) |
| | Mflv_3614 | KEGG: mmc:Mmcs_3064 hypothetical protein. (127 aa) |
| | Mflv_3615 | PFAM: Lysine exporter protein (LYSE/YGGA); KEGG: mva:Mvan_2802 lysine exporter protein (LysE/YggA). (208 aa) |
| | ilvA | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (429 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (359 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (220 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (401 aa) |
| | Mflv_3760 | TIGRFAM: shikimate-5-dehydrogenase; PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding, N-terminal domain protein; KEGG: mmc:Mmcs_2349 shikimate-5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (275 aa) |
| | Mflv_3937 | PFAM: inositol monophosphatase; KEGG: mmc:Mmcs_2187 inositol-1(or 4)-monophosphatase. (299 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (289 aa) |
| | Mflv_3990 | N-acetylglutamate synthase; PFAM: GCN5-related N-acetyltransferase; KEGG: mva:Mvan_2394 GCN5-related N-acetyltransferase; Belongs to the acetyltransferase family. (161 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (302 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (245 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (481 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (336 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa) |
| | Mflv_4238 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: mmc:Mmcs_1907 acetolactate synthase, small subunit. (166 aa) |
| | Mflv_4239 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: mmc:Mmcs_1906 acetolactate synthase, large subunit, biosynthetic type. (620 aa) |
| | Mflv_4276 | KEGG: mmc:Mmcs_1853 phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase, type 3. (410 aa) |
| | Mflv_4352 | PFAM: dihydrodipicolinate synthetase; KEGG: mpa:MAP2392c hypothetical protein; Belongs to the DapA family. (335 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (147 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (446 aa) |
| | Mflv_4919 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (351 aa) |
| | Mflv_5071 | Aminotransferase; TIGRFAM: ornithine aminotransferase; PFAM: aminotransferase class-III; KEGG: mmc:Mmcs_0992 ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (401 aa) |
| | ilvD-2 | KEGG: sco:SCO3345 dihydroxy acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (613 aa) |
