STRINGSTRING
Mflv_0878 Mflv_0878 Mflv_1391 Mflv_1391 Mflv_1697 Mflv_1697 Mflv_1861 Mflv_1861 Mflv_1981 Mflv_1981 Mflv_2223 Mflv_2223 Mflv_2347 Mflv_2347 Mflv_2544 Mflv_2544 Mflv_2792 Mflv_2792 priA-2 priA-2 Mflv_3796 Mflv_3796 ruvB ruvB ruvA ruvA Mflv_3896 Mflv_3896 Mflv_3930 Mflv_3930 Mflv_4139 Mflv_4139 recG recG Mflv_4660 Mflv_4660 Mflv_4665 Mflv_4665 Mflv_4666 Mflv_4666 recC recC recB recB recD recD Mflv_5149 Mflv_5149 Mflv_5152 Mflv_5152 Mflv_5176 Mflv_5176
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Mflv_0878Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (879 aa)
Mflv_1391PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like; KEGG: mmc:Mmcs_4799 DEAD/DEAH box helicase-like protein. (781 aa)
Mflv_1697PFAM: helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like; KEGG: mva:Mvan_5056 type III restriction enzyme, res subunit. (549 aa)
Mflv_1861TIGRFAM: ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase; KEGG: mmc:Mmcs_4330 ATP-dependent DNA helicase PcrA. (780 aa)
Mflv_1981Hypothetical protein. (392 aa)
Mflv_2223KEGG: mmc:Mmcs_3969 nuclease (RecB family)-like protein. (1163 aa)
Mflv_2347SMART: helicase c2; DEAD-like helicases-like; KEGG: mmc:Mmcs_3855 helicase C2. (670 aa)
Mflv_2544PFAM: protein of unknown function DUF853, NPT hydrolase putative; KEGG: mmc:Mmcs_3639 protein of unknown function DUF853, NPT hydrolase putative. (526 aa)
Mflv_2792KEGG: mmc:Mmcs_1430 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member-like protein. (1955 aa)
priA-2Replication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (648 aa)
Mflv_3796KEGG: mmc:Mmcs_5266 putative helicase. (735 aa)
ruvBHolliday junction DNA helicase subunit RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (357 aa)
ruvADNA recombination protein RuvA, domain I; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (195 aa)
Mflv_3896Hypothetical protein. (692 aa)
Mflv_3930PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mmc:Mmcs_2194 nucleic acid binding, OB-fold, tRNA/helicase-type. (136 aa)
Mflv_4139Mg chelatase, subunit ChlI; KEGG: mpa:MAP2962c magnesium chelatase family protein; TIGRFAM: Mg chelatase, subunit ChlI; PFAM: magnesium chelatase, ChlI subunit; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase. (502 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (753 aa)
Mflv_4660ATP-dependent DNA helicase, Rep family; PFAM: UvrD/REP helicase; HRDC domain protein; KEGG: mmc:Mmcs_1409 UvrD/REP helicase. (707 aa)
Mflv_4665PFAM: UvrD/REP helicase; KEGG: mmc:Mmcs_1404 UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. (1091 aa)
Mflv_4666PFAM: UvrD/REP helicase; KEGG: mva:Mvan_1801 UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. (1038 aa)
recCDNA helicase/exodeoxyribonuclease V, gamma subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recomb [...] (1083 aa)
recBDNA helicase/exodeoxyribonuclease V, beta subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombi [...] (1109 aa)
recDDNA helicase/exodeoxyribonuclease V, alpha subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recomb [...] (555 aa)
Mflv_5149SMART: AAA ATPase; KEGG: fal:FRAAL5509 hypothetical protein. (1031 aa)
Mflv_5152SMART: AAA ATPase; KEGG: mmc:Mmcs_0861 ATPas. (779 aa)
Mflv_5176KEGG: mva:Mvan_1146 conserved hypothetical protein. (551 aa)
Your Current Organism:
Mycolicibacterium gilvum
NCBI taxonomy Id: 350054
Other names: M. gilvum PYR-GCK, Mycobacterium flavescens ATCC 700033, Mycobacterium flavescens PYR-GCK, Mycobacterium gilvum PYR-GCK, Mycolicibacterium gilvum PYR-GCK
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