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Mvan_5826 Mvan_5826 Mvan_5825 Mvan_5825 pheA pheA Mvan_5563 Mvan_5563 Mvan_5562 Mvan_5562 Mvan_5345 Mvan_5345 ectC ectC Mvan_5266 Mvan_5266 Mvan_5238 Mvan_5238 Mvan_5236 Mvan_5236 Mvan_5190 Mvan_5190 Mvan_4992 Mvan_4992 eno eno Mvan_4681 Mvan_4681 Mvan_4674 Mvan_4674 fumC fumC Mvan_4642 Mvan_4642 Mvan_4549 Mvan_4549 Mvan_4424 Mvan_4424 Mvan_4410 Mvan_4410 Mvan_4393 Mvan_4393 Mvan_4253 Mvan_4253 Mvan_4230 Mvan_4230 Mvan_4219 Mvan_4219 Mvan_4207 Mvan_4207 Mvan_4106 Mvan_4106 Mvan_4088 Mvan_4088 Mvan_4083 Mvan_4083 Mvan_4005 Mvan_4005 Mvan_3990 Mvan_3990 Mvan_3987 Mvan_3987 Mvan_3936 Mvan_3936 Mvan_3603 Mvan_3603 Mvan_3400 Mvan_3400 Mvan_3046 Mvan_3046 Mvan_2978 Mvan_2978 Mvan_2923 Mvan_2923 Mvan_2877 Mvan_2877 trpA trpA trpB trpB hisB hisB Mvan_2745 Mvan_2745 Mvan_2741 Mvan_2741 Mvan_2632 Mvan_2632 Mvan_2610 Mvan_2610 dapA dapA Mvan_2340 Mvan_2340 leuD leuD leuC leuC Mvan_2089 Mvan_2089 Mvan_1993 Mvan_1993 Mvan_1987 Mvan_1987 Mvan_1985 Mvan_1985 Mvan_1984 Mvan_1984 Mvan_1983 Mvan_1983 Mvan_1970 Mvan_1970 Mvan_1871 Mvan_1871 Mvan_1818 Mvan_1818 aroQ aroQ Mvan_1625 Mvan_1625 Mvan_1528 Mvan_1528 Mvan_1504 Mvan_1504 nnrE nnrE Mvan_1365 Mvan_1365 Mvan_1272 Mvan_1272 Mvan_1270 Mvan_1270 Mvan_1232 Mvan_1232 Mvan_1230 Mvan_1230 ilvD-2 ilvD-2 Mvan_1030 Mvan_1030 Mvan_1029 Mvan_1029 Mvan_1017 Mvan_1017 menC menC Mvan_0847 Mvan_0847 Mvan_0846 Mvan_0846 Mvan_0842 Mvan_0842 Mvan_0780 Mvan_0780 Mvan_0648 Mvan_0648 Mvan_0647 Mvan_0647 Mvan_0595 Mvan_0595 Mvan_0558 Mvan_0558 Mvan_0472 Mvan_0472 Mvan_0469 Mvan_0469 Mvan_0452 Mvan_0452 Mvan_0340 Mvan_0340 Mvan_0301 Mvan_0301 Mvan_0222 Mvan_0222 Mvan_0219 Mvan_0219 ilvD ilvD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Mvan_5826KEGG: rpc:RPC_2749 nitrile hydratase. (244 aa)
Mvan_5825TIGRFAM: nitrile hydratase, alpha subunit; PFAM: Nitrile hydratase alpha chain; KEGG: rpb:RPB_2704 nitrile hydratase, alpha subunit. (206 aa)
pheAPFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: mmc:Mmcs_5034 prephenate dehydratase. (312 aa)
Mvan_5563PFAM: dehydratase, large subunit; dehydratase, medium subunit; KEGG: mmc:Mmcs_4954 glycerol dehydratase. (746 aa)
Mvan_5562KEGG: mmc:Mmcs_4953 propanediol utilization: dehydratase, small subunit. (119 aa)
Mvan_5345Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (206 aa)
ectCEctoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (130 aa)
Mvan_5266PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_4683 enoyl-CoA hydratase/isomerase. (251 aa)
Mvan_5238PFAM: MaoC domain protein dehydratase; KEGG: mmc:Mmcs_4663 MaoC-like dehydratase. (286 aa)
Mvan_5236PFAM: Hydratase/decarboxylase; KEGG: mmc:Mmcs_4661 4-oxalocrotonate decarboxylase. (261 aa)
Mvan_5190PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_4607 enoyl-CoA hydratase/isomerase. (301 aa)
Mvan_4992PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_4431 enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (246 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
Mvan_4681PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_4156 enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (260 aa)
Mvan_4674KEGG: mmc:Mmcs_4149 cystathionine beta-synthase; TIGRFAM: cystathionine beta-synthase; PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (464 aa)
fumCFumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (471 aa)
Mvan_4642KEGG: mmc:Mmcs_1071 hypothetical protein. (149 aa)
Mvan_4549PFAM: transcriptional coactivator/pterin dehydratase; KEGG: mpa:MAP2623 pterin-4-alpha-carbinolamine dehydratase. (93 aa)
Mvan_4424PFAM: carbonic anhydrase; KEGG: mmc:Mmcs_3921 carbonic anhydrase. (163 aa)
Mvan_4410PFAM: MaoC domain protein dehydratase; KEGG: mbo:Mb0135 hypothetical protein. (157 aa)
Mvan_4393PFAM: Hydratase/decarboxylase; KEGG: nfa:nfa33180 putative hydratase. (283 aa)
Mvan_4253PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mpa:MAP0683 hypothetical protein. (254 aa)
Mvan_4230PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_3763 enoyl-CoA hydratase/isomerase. (327 aa)
Mvan_4219PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_3753 enoyl-CoA hydratase/isomerase. (260 aa)
Mvan_4207PFAM: Enoyl-CoA hydratase/isomerase; KEGG: rha:RHA1_ro02289 possible enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (270 aa)
Mvan_4106Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (798 aa)
Mvan_4088PFAM: MaoC domain protein dehydratase; KEGG: mmc:Mmcs_3628 MaoC-like dehydratase. (164 aa)
Mvan_4083PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_3623 enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (250 aa)
Mvan_4005PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mbo:Mb1970c enoyl-CoA hydratase. (302 aa)
Mvan_3990PFAM: Enoyl-CoA hydratase/isomerase; KEGG: tfu:Tfu_0067 probable enoyl-CoA hydratase (unsaturated acyl-CoA hydratase) (crotonase). (267 aa)
Mvan_3987KEGG: reu:Reut_B4756 hypothetical protein. (152 aa)
Mvan_3936PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_3540 enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (271 aa)
Mvan_3603PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_3333 enoyl-CoA hydratase/isomerase. (264 aa)
Mvan_3400PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mpa:MAP3925 EchA8_2. (269 aa)
Mvan_3046PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mpa:MAP1593 putative enoyl-CoA hydratase/isomerase. (252 aa)
Mvan_2978KEGG: nfa:nfa55430 O-succinylbenzoate-CoA synthase. (258 aa)
Mvan_2923Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (433 aa)
Mvan_2877PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_0306 enoyl-CoA hydratase/isomerase. (273 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (262 aa)
trpBTryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (420 aa)
hisBPFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmc:Mmcs_3061 imidazoleglycerol-phosphate dehydratase. (208 aa)
Mvan_2745TIGRFAM: aconitate hydratase 1; PFAM: aconitate hydratase domain protein; KEGG: mmc:Mmcs_2449 aconitate hydratase 1. (954 aa)
Mvan_2741PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_2445 enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (276 aa)
Mvan_2632Phosphoenolpyruvate synthase; PFAM: pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile region; KEGG: bld:BLi02241 close homolog to Pps phosphoenolpyruvate synthase; RBL01875. (886 aa)
Mvan_2610PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mpa:MAP1681c hypothetical protein. (257 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (303 aa)
Mvan_2340PFAM: MaoC domain protein dehydratase; KEGG: nfa:nfa20930 hypothetical protein. (297 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (481 aa)
Mvan_2089PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mbo:Mb3065c enoyl-CoA hydratase. (225 aa)
Mvan_1993PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mpa:MAP2390c enoyl-CoA hydratase. (294 aa)
Mvan_1987PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mpa:MAP2395c hypothetical protein. (299 aa)
Mvan_1985PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_1766 enoyl-CoA hydratase/isomerase. (266 aa)
Mvan_1984PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mpa:MAP2398 hypothetical protein. (270 aa)
Mvan_1983PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_1764 enoyl-CoA hydratase/isomerase. (259 aa)
Mvan_1970PFAM: MaoC domain protein dehydratase; KEGG: mmc:Mmcs_1751 MaoC-like dehydratase. (168 aa)
Mvan_1871PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_1563 enoyl-CoA hydratase/isomerase. (258 aa)
Mvan_1818Pyruvate, water dikinase; PFAM: pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile region; KEGG: cel:T21C9.6 Hypothetical protein T21C9.6. (788 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (147 aa)
Mvan_1625PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_1254 enoyl-CoA hydratase/isomerase. (259 aa)
Mvan_1528PFAM: MaoC domain protein dehydratase; KEGG: mpa:MAP3479c hypothetical protein. (288 aa)
Mvan_1504Thiocyanate hydrolase; PFAM: Nitrile hydratase alpha chain; KEGG: mmc:Mmcs_5258 thiocyanate hydrolase. (234 aa)
nnrECarbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] (470 aa)
Mvan_1365TIGRFAM: dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain; KEGG: mpa:MAP4225c dTDP-glucose-4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (335 aa)
Mvan_1272PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mpa:MAP4136 enoyl-coA hydratase/isomerase family protein; Belongs to the enoyl-CoA hydratase/isomerase family. (265 aa)
Mvan_1270PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_0976 enoyl-CoA hydratase/isomerase. (302 aa)
Mvan_1232KEGG: mmc:Mmcs_0920 hypothetical protein; Belongs to the UPF0336 family. (177 aa)
Mvan_1230KEGG: mmc:Mmcs_0918 hypothetical protein; Belongs to the UPF0336 family. (159 aa)
ilvD-2KEGG: sco:SCO3345 dihydroxy acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (613 aa)
Mvan_1030PFAM: dihydrodipicolinate synthetase; KEGG: tfu:Tfu_1718 putative dihydrodipicolinate synthase; Belongs to the DapA family. (313 aa)
Mvan_1029PFAM: Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein; KEGG: ani:AN0613.2 hypothetical protein. (419 aa)
Mvan_1017D-glucarate dehydratase; PFAM: Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein; KEGG: nfa:nfa35070 putative glucarate dehydratase. (445 aa)
menCMandelate racemase/muconate lactonizing enzyme, C-terminal domain protein; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (346 aa)
Mvan_0847Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mmc:Mmcs_0679 porphobilinogen synthase; Belongs to the ALAD family. (326 aa)
Mvan_0846uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: mmc:Mmcs_0678 uroporphyrinogen III synthase HEM4. (571 aa)
Mvan_0842KEGG: mmc:Mmcs_0673 MaoC-like dehydratase; Belongs to the UPF0336 family. (180 aa)
Mvan_0780PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_0615 enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (300 aa)
Mvan_0648KEGG: rpb:RPB_2704 nitrile hydratase, alpha subunit; TIGRFAM: nitrile hydratase, alpha subunit; PFAM: Nitrile hydratase alpha chain. (198 aa)
Mvan_0647Nitrile hydratase; NHase catalyzes the hydration of various nitrile compounds to the corresponding amides; Belongs to the nitrile hydratase subunit beta family. (230 aa)
Mvan_0595PFAM: Hydratase/decarboxylase; KEGG: mta:Moth_1777 4-oxalocrotonate decarboxylase. (262 aa)
Mvan_0558PFAM: dihydrodipicolinate synthetase; KEGG: mmc:Mmcs_1696 dihydrodipicolinate synthetase; Belongs to the DapA family. (325 aa)
Mvan_0472PFAM: dihydrodipicolinate synthetase; KEGG: mmc:Mmcs_1632 dihydrodipicolinate synthetase; Belongs to the DapA family. (341 aa)
Mvan_0469PFAM: dihydrodipicolinate synthetase; KEGG: mmc:Mmcs_1629 dihydrodipicolinate synthetase; Belongs to the DapA family. (332 aa)
Mvan_0452PFAM: dihydrodipicolinate synthetase; KEGG: mpa:MAP1059 probable dihydrodipicolinate synthetase; Belongs to the DapA family. (296 aa)
Mvan_0340PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mpa:MAP1593 putative enoyl-CoA hydratase/isomerase. (254 aa)
Mvan_0301PFAM: transcriptional regulator domain protein; Uroporphyrinogen III synthase HEM4; KEGG: mmc:Mmcs_0263 uroporphyrinogen III synthase HEM4. (380 aa)
Mvan_0222KEGG: mmc:Mmcs_0183 hypothetical protein. (328 aa)
Mvan_0219PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mmc:Mmcs_0178 enoyl-CoA hydratase/isomerase. (295 aa)
ilvDKEGG: mmc:Mmcs_0146 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (565 aa)
Your Current Organism:
Mycolicibacterium vanbaalenii
NCBI taxonomy Id: 350058
Other names: M. vanbaalenii PYR-1, Mycobacterium sp. PYR-1, Mycobacterium vanbaalenii DSM 7251, Mycobacterium vanbaalenii PYR-1, Mycolicibacterium vanbaalenii DSM 7251, Mycolicibacterium vanbaalenii PYR-1
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