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Mvan_0327 Mvan_0327 Mvan_0750 Mvan_0750 Mvan_0794 Mvan_0794 gpmA gpmA Mvan_1016 Mvan_1016 Mvan_1178 Mvan_1178 Mvan_1179 Mvan_1179 Mvan_1202 Mvan_1202 Mvan_1300 Mvan_1300 Mvan_1572 Mvan_1572 Mvan_1606 Mvan_1606 Mvan_1866 Mvan_1866 Mvan_2083 Mvan_2083 Mvan_2128 Mvan_2128 Mvan_2142 Mvan_2142 Mvan_2218 Mvan_2218 Mvan_2580 Mvan_2580 ilvA ilvA trpB trpB trpA trpA Mvan_2923 Mvan_2923 Mvan_2938 Mvan_2938 gcvP gcvP gcvH gcvH Mvan_3407 Mvan_3407 Mvan_3569 Mvan_3569 gcvT gcvT thrB thrB Mvan_4347 Mvan_4347 Mvan_4348 Mvan_4348 glyA glyA Mvan_4674 Mvan_4674 serC serC Mvan_5271 Mvan_5271 ectC ectC Mvan_5273 Mvan_5273 ectA ectA asd asd Mvan_5504 Mvan_5504 Mvan_5513 Mvan_5513 Mvan_5578 Mvan_5578 Mvan_5894 Mvan_5894
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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Your Input:
Mvan_0327PFAM: glucose-methanol-choline oxidoreductase; GMC oxidoreductase; KEGG: rpc:RPC_2481 glucose-methanol-choline oxidoreductase. (522 aa)
Mvan_0750KEGG: mmc:Mmcs_0593 CDP-diacylglycerol--serine O-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (283 aa)
Mvan_0794TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: mmc:Mmcs_0631 dihydrolipoamide dehydrogenase. (464 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (250 aa)
Mvan_1016PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: rha:RHA1_ro02790 probable phosphoglycerate dehydrogenase. (321 aa)
Mvan_1178PFAM: amine oxidase; FAD dependent oxidoreductase; KEGG: nfa:nfa30780 putative oxidoreductase. (454 aa)
Mvan_1179L-threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: dde:Dde_1657 threonine aldolase. (343 aa)
Mvan_1202PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: ret:RHE_PE00406 probable aminomethyltransferase protein; Belongs to the GcvT family. (752 aa)
Mvan_1300PFAM: glucose-methanol-choline oxidoreductase; GMC oxidoreductase; KEGG: mmc:Mmcs_1005 glucose-methanol-choline oxidoreductase. (478 aa)
Mvan_1572PFAM: aldehyde dehydrogenase; KEGG: mmc:Mmcs_1220 betaine-aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (470 aa)
Mvan_1606PFAM: glucose-methanol-choline oxidoreductase; GMC oxidoreductase; KEGG: rpc:RPC_2481 glucose-methanol-choline oxidoreductase. (539 aa)
Mvan_1866Amine oxidase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; amine oxidase; FAD dependent oxidoreductase; KEGG: mmc:Mmcs_1556 amine oxidase (flavin-containing). (447 aa)
Mvan_2083KEGG: mmc:Mmcs_1853 phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase, type 3. (419 aa)
Mvan_2128KEGG: mpa:MAP3033c D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (528 aa)
Mvan_2142PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: mmc:Mmcs_1928 Cys/Met metabolism pyridoxal-phosphate-dependent enzymes. (369 aa)
Mvan_2218PFAM: copper amine oxidase; KEGG: mmc:Mmcs_2000 amine oxidase (copper-containing). (659 aa)
Mvan_2580PFAM: aldehyde dehydrogenase; KEGG: mmc:Mmcs_2273 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (477 aa)
ilvAL-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (429 aa)
trpBTryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (420 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (262 aa)
Mvan_2923Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (433 aa)
Mvan_2938PFAM: glucose-methanol-choline oxidoreductase; GMC oxidoreductase; KEGG: mmc:Mmcs_2628 glucose-methanol-choline oxidoreductase. (564 aa)
gcvPGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (950 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (131 aa)
Mvan_3407PFAM: copper amine oxidase; KEGG: cyb:CYB_2794 putative copper methylamine oxidase. (670 aa)
Mvan_3569PFAM: glycerate kinase; KEGG: mbo:Mb2228c glycerate kinase; Belongs to the glycerate kinase type-1 family. (353 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (369 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (314 aa)
Mvan_4347Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (359 aa)
Mvan_4348PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: mmc:Mmcs_3896 homoserine dehydrogenase. (438 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (487 aa)
Mvan_4674KEGG: mmc:Mmcs_4149 cystathionine beta-synthase; TIGRFAM: cystathionine beta-synthase; PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (464 aa)
serCAminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (371 aa)
Mvan_5271TIGRFAM: ectoine hydroxylase; PFAM: Phytanoyl-CoA dioxygenase; KEGG: mmc:Mmcs_4193 ectoine hydroxylase. (304 aa)
ectCEctoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (130 aa)
Mvan_5273Diaminobutyrate aminotransferase apoenzyme; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (429 aa)
ectADiaminobutyrate acetyltransferase; Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. (194 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
Mvan_5504KEGG: mmc:Mmcs_4889 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (421 aa)
Mvan_5513PFAM: FAD dependent oxidoreductase; KEGG: mmc:Mmcs_4896 FAD dependent oxidoreductase. (398 aa)
Mvan_5578PFAM: amine oxidase; KEGG: nfa:nfa30780 putative oxidoreductase. (456 aa)
Mvan_5894PFAM: glucose-methanol-choline oxidoreductase; GMC oxidoreductase; KEGG: mmc:Mmcs_4938 glucose-methanol-choline oxidoreductase. (534 aa)
Your Current Organism:
Mycolicibacterium vanbaalenii
NCBI taxonomy Id: 350058
Other names: M. vanbaalenii PYR-1, Mycobacterium sp. PYR-1, Mycobacterium vanbaalenii DSM 7251, Mycobacterium vanbaalenii PYR-1, Mycolicibacterium vanbaalenii DSM 7251, Mycolicibacterium vanbaalenii PYR-1
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