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ilvD ilvD Mvan_0618 Mvan_0618 Mvan_0731 Mvan_0731 ilvD-2 ilvD-2 Mvan_1352 Mvan_1352 Mvan_2122 Mvan_2122 Mvan_2123 Mvan_2123 ilvC ilvC leuB leuB leuC leuC leuD leuD Mvan_2394 Mvan_2394 Mvan_2745 Mvan_2745 Mvan_3146 Mvan_3146 Mvan_3212 Mvan_3212 argD argD argB argB argJ argJ argC argC Mvan_3573 Mvan_3573 Mvan_4516 Mvan_4516 Mvan_4954 Mvan_4954 Mvan_5022 Mvan_5022 Mvan_5025 Mvan_5025 Mvan_5213 Mvan_5213 Mvan_5273 Mvan_5273 asd asd Mvan_5504 Mvan_5504 leuA leuA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene co-occurrence
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textmining
co-expression
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Your Input:
ilvDKEGG: mmc:Mmcs_0146 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (565 aa)
Mvan_0618L-aspartate aminotransferase apoenzyme; PFAM: aminotransferase, class I and II; KEGG: mbo:Mb0344c probable aspartate aminotransferase AspC (transaminase A) (ASPAT). (426 aa)
Mvan_0731PFAM: GCN5-related N-acetyltransferase; FR47 domain protein; KEGG: mmc:Mmcs_0568 GCN5-related N-acetyltransferase. (297 aa)
ilvD-2KEGG: sco:SCO3345 dihydroxy acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (613 aa)
Mvan_1352PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: mpa:MAP4208 hypothetical protein. (552 aa)
Mvan_2122TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: mmc:Mmcs_1906 acetolactate synthase, large subunit, biosynthetic type. (625 aa)
Mvan_2123TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: mmc:Mmcs_1907 acetolactate synthase, small subunit. (166 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (336 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (481 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
Mvan_2394N-acetylglutamate synthase; PFAM: GCN5-related N-acetyltransferase; KEGG: mmc:Mmcs_2122 GCN5-related N-acetyltransferase. (173 aa)
Mvan_2745TIGRFAM: aconitate hydratase 1; PFAM: aconitate hydratase domain protein; KEGG: mmc:Mmcs_2449 aconitate hydratase 1. (954 aa)
Mvan_3146PFAM: aminotransferase class-III; KEGG: gsu:GSU0151 acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (408 aa)
Mvan_3212KEGG: mmc:Mmcs_1209 isocitrate dehydrogenase, NADP-dependent; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate dehydrogenase NADP-dependent, monomeric type; Belongs to the monomeric-type IDH family. (746 aa)
argDAminotransferase; TIGRFAM: acetylornithine and succinylornithine aminotransferases; PFAM: aminotransferase class-III; KEGG: mmc:Mmcs_2969 acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (291 aa)
argJGlutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (398 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa)
Mvan_3573KEGG: mmc:Mmcs_3308 branched-chain amino acid aminotransferase; TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV. (367 aa)
Mvan_4516PFAM: aminotransferase, class IV; KEGG: afm:Afu7g06900 branched-chain amino acid aminotransferase protein. (337 aa)
Mvan_4954PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: mmc:Mmcs_4396 thiamine pyrophosphate enzyme-like TPP-binding protein; Belongs to the TPP enzyme family. (573 aa)
Mvan_5022KEGG: mmc:Mmcs_4456 citrate synthase I; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (434 aa)
Mvan_5025PFAM: Citrate synthase; KEGG: mbo:Mb0913c citrate synthase; Belongs to the citrate synthase family. (371 aa)
Mvan_5213PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: mbo:Mb3539c probable acetohydroxyacid synthase IlvX (acetolactate synthase). (519 aa)
Mvan_5273Diaminobutyrate aminotransferase apoenzyme; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (429 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
Mvan_5504KEGG: mmc:Mmcs_4889 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (421 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (612 aa)
Your Current Organism:
Mycolicibacterium vanbaalenii
NCBI taxonomy Id: 350058
Other names: M. vanbaalenii PYR-1, Mycobacterium sp. PYR-1, Mycobacterium vanbaalenii DSM 7251, Mycobacterium vanbaalenii PYR-1, Mycolicibacterium vanbaalenii DSM 7251, Mycolicibacterium vanbaalenii PYR-1
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