(77 nodes) Mixed, incl. Phase I - Functionalization of compounds, and Isoprenoid biosynthetic process network (Thalassiosira pseudonana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	THAPS_10895	NADP-dependent ferredoxin reductase and adrenodoxin reductase, fprA-like protein. (601 aa)
	DXR1	1-deoxy-D-xylulose 5-phosphate reductoisomerase. (482 aa)
	B8BR73_THAPS	Uncharacterized protein. (80 aa)
	FAH1	Fatty acid hydroxylase, cytochrome P450; Belongs to the cytochrome P450 family. (533 aa)
	B8BRW8_THAPS	Uncharacterized protein. (344 aa)
	B8BS75_THAPS	Mevalonate disphosphate decarboxylase-like protein. (346 aa)
	B8BSB0_THAPS	Methyl transferase-like protein. (308 aa)
	B8BSS3_THAPS	Isopentenyl-dephosphate delta-isomerase-like protein. (254 aa)
	HMCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (449 aa)
	B8BTG9_THAPS	4-diphosphocytidyl-2c-methyl-d-erythritol kinase. (296 aa)
	B8BTM4_THAPS	Uncharacterized protein. (460 aa)
	B8BTY9_THAPS	SAM_MT_ERG6_SMT domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family. (308 aa)
	B8BU16_THAPS	Methyltransf_11 domain-containing protein. (317 aa)
	B8BU66_THAPS	Mevalonate kinase. (315 aa)
	B8BUD7_THAPS	DUF2470 domain-containing protein. (1490 aa)
	B8BUH0_THAPS	Uncharacterized protein. (713 aa)
	B8BUU5_THAPS	Elongation factor-2 kinase like protein. (668 aa)
	B8BUY8_THAPS	Phosphatidate phosphatase. (127 aa)
	CAS1	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (685 aa)
	B8BVH5_THAPS	Uncharacterized protein; Belongs to the cytochrome P450 family. (159 aa)
	GGPS5	Geranylgeranyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (320 aa)
	B8BVW8_THAPS	Uncharacterized protein; Belongs to the cytochrome P450 family. (167 aa)
	B8BWN1_THAPS	Uncharacterized protein. (418 aa)
	B8BWW2_THAPS	PEROXIDASE_4 domain-containing protein; Belongs to the peroxidase family. (865 aa)
	B8BWZ8_THAPS	Uncharacterized protein. (472 aa)
	B8BXK3_THAPS	Uncharacterized protein. (544 aa)
	GGPS1	Geranylgeranyl pyrophosphate synthetase; Belongs to the FPP/GGPP synthase family. (339 aa)
	B8BXY6_THAPS	Uncharacterized protein. (442 aa)
	B8BYA8_THAPS	Uncharacterized protein. (313 aa)
	B8BYG3_THAPS	GHMP_kinases_N domain-containing protein. (744 aa)
	B8BZC6_THAPS	acidPPc domain-containing protein. (278 aa)
	B8BZD9_THAPS	Uncharacterized protein. (184 aa)
	B8BZI1_THAPS	Obtusifoliol 14-alpha demethylase; Belongs to the cytochrome P450 family. (445 aa)
	B8BZL6_THAPS	3Beta_HSD domain-containing protein. (402 aa)
	B8C078_THAPS	4-coumarate-coa ligase. (467 aa)
	B8C081_THAPS	Uncharacterized protein. (342 aa)
	B8C0R4_THAPS	3-hydroxy-3-methylglutaryl coenzyme A reductase. (368 aa)
	B8C0S0_THAPS	Carrier domain-containing protein. (1421 aa)
	B8C0U1_THAPS	RmlD_sub_bind domain-containing protein. (387 aa)
	B8C0U5_THAPS	RmlD_sub_bind domain-containing protein. (331 aa)
	B8C1D0_THAPS	Uncharacterized protein. (326 aa)
	B8C234_THAPS	2Fe-2S ferredoxin-type domain-containing protein. (195 aa)
	B8C2J9_THAPS	Uncharacterized protein. (783 aa)
	B8C2Y3_THAPS	Uncharacterized protein. (462 aa)
	B8C314_THAPS	Uncharacterized protein. (543 aa)
	B8C3A5_THAPS	Methyltransf_11 domain-containing protein. (380 aa)
	B8C3E2_THAPS	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (318 aa)
	B8C3T3_THAPS	Uncharacterized protein. (391 aa)
	B8C471_THAPS	Uncharacterized protein. (591 aa)
	B8C620_THAPS	AMP-binding domain-containing protein. (846 aa)
	B8C6F1_THAPS	Methyltransf_25 domain-containing protein. (506 aa)
	B8C6Z4_THAPS	Uncharacterized protein; Belongs to the cytochrome P450 family. (458 aa)
	B8C702_THAPS	Methyltransferase. (406 aa)
	B8C7A6_THAPS	Uncharacterized protein. (328 aa)
	GcpE	Gcpe-like protein. (686 aa)
	B8C7I2_THAPS	Elongation factor kinase. (127 aa)
	B8C7I4_THAPS	Methyltransferase. (236 aa)
	B8C7Q9_THAPS	Uncharacterized protein; Belongs to the cytochrome P450 family. (463 aa)
	B8C7V7_THAPS	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family. (376 aa)
	B8C8C0_THAPS	Uncharacterized protein. (736 aa)
	SMT1	Methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family. (337 aa)
	CYP2	Cytochrome P450; Belongs to the cytochrome P450 family. (546 aa)
	B8CCY2_THAPS	Uncharacterized protein. (242 aa)
	FPS1	Probable farnesyl pyrophosphate synthetase; Belongs to the FPP/GGPP synthase family. (360 aa)
	B8CD73_THAPS	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. (263 aa)
	B8CDA5_THAPS	Uncharacterized protein; Belongs to the cytochrome P450 family. (233 aa)
	GGPS3	Geranylgeranyl diphosphate synthetase; Belongs to the FPP/GGPP synthase family. (349 aa)
	B8CE34_THAPS	Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (66 aa)
	B8CEM2_THAPS	NAD or nadp-dependent reductase. (616 aa)
	B8CF14_THAPS	Amino_oxidase domain-containing protein. (874 aa)
	B8CF18_THAPS	ANK_REP_REGION domain-containing protein. (1443 aa)
	B8LBR1_THAPS	Predicted protein. (335 aa)
	B8LCI8_THAPS	Predicted protein. (494 aa)
	B8LCJ0_THAPS	Predicted protein. (599 aa)
	B8LDS9_THAPS	Uncharacterized protein; Belongs to the cytochrome P450 family. (206 aa)
	B8LE89_THAPS	Predicted protein. (737 aa)
	B8LEZ5_THAPS	Uncharacterized protein; Belongs to the cytochrome P450 family. (100 aa)

Your Current Organism:

Thalassiosira pseudonana

NCBI taxonomy Id: 35128
Other names: T. pseudonana

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B8BR73_THAPS	B8BUY8_THAPS	B8BR73	B8BUY8	Uncharacterized protein.	Phosphatidate phosphatase.	0.400
B8BR73_THAPS	B8BZC6_THAPS	B8BR73	B8BZC6	Uncharacterized protein.	acidPPc domain-containing protein.	0.400
B8BR73_THAPS	B8C234_THAPS	B8BR73	B8C234	Uncharacterized protein.	2Fe-2S ferredoxin-type domain-containing protein.	0.408
B8BR73_THAPS	B8CE34_THAPS	B8BR73	B8CE34	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.426
B8BR73_THAPS	B8LCJ0_THAPS	B8BR73	B8LCJ0	Uncharacterized protein.	Predicted protein.	0.425
B8BRW8_THAPS	B8BSS3_THAPS	B8BRW8	B8BSS3	Uncharacterized protein.	Isopentenyl-dephosphate delta-isomerase-like protein.	0.463
B8BRW8_THAPS	B8BWW2_THAPS	B8BRW8	B8BWW2	Uncharacterized protein.	PEROXIDASE_4 domain-containing protein; Belongs to the peroxidase family.	0.519
B8BRW8_THAPS	B8C0R4_THAPS	B8BRW8	B8C0R4	Uncharacterized protein.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.544
B8BRW8_THAPS	CAS1	B8BRW8	B8BV49	Uncharacterized protein.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.401
B8BRW8_THAPS	HMCS1	B8BRW8	B8BSY2	Uncharacterized protein.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.555
B8BS75_THAPS	B8BSS3_THAPS	B8BS75	B8BSS3	Mevalonate disphosphate decarboxylase-like protein.	Isopentenyl-dephosphate delta-isomerase-like protein.	0.979
B8BS75_THAPS	B8BTG9_THAPS	B8BS75	B8BTG9	Mevalonate disphosphate decarboxylase-like protein.	4-diphosphocytidyl-2c-methyl-d-erythritol kinase.	0.495
B8BS75_THAPS	B8BTM4_THAPS	B8BS75	B8BTM4	Mevalonate disphosphate decarboxylase-like protein.	Uncharacterized protein.	0.495
B8BS75_THAPS	B8BU66_THAPS	B8BS75	B8BU66	Mevalonate disphosphate decarboxylase-like protein.	Mevalonate kinase.	0.954
B8BS75_THAPS	B8BWW2_THAPS	B8BS75	B8BWW2	Mevalonate disphosphate decarboxylase-like protein.	PEROXIDASE_4 domain-containing protein; Belongs to the peroxidase family.	0.608
B8BS75_THAPS	B8BXY6_THAPS	B8BS75	B8BXY6	Mevalonate disphosphate decarboxylase-like protein.	Uncharacterized protein.	0.625
B8BS75_THAPS	B8BYG3_THAPS	B8BS75	B8BYG3	Mevalonate disphosphate decarboxylase-like protein.	GHMP_kinases_N domain-containing protein.	0.963
B8BS75_THAPS	B8BZD9_THAPS	B8BS75	B8BZD9	Mevalonate disphosphate decarboxylase-like protein.	Uncharacterized protein.	0.541
B8BS75_THAPS	B8BZI1_THAPS	B8BS75	B8BZI1	Mevalonate disphosphate decarboxylase-like protein.	Obtusifoliol 14-alpha demethylase; Belongs to the cytochrome P450 family.	0.616
B8BS75_THAPS	B8C0R4_THAPS	B8BS75	B8C0R4	Mevalonate disphosphate decarboxylase-like protein.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.681