(12 nodes) Tricarboxylic acid cycle enzyme complex network (Thalassiosira pseudonana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	B8BTA3_THAPS	Alpha-keto acid dehydrogenase. (323 aa)
	B8BUT0_THAPS	Transket_pyr domain-containing protein. (814 aa)
	SCS2	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (299 aa)
	B8C935_THAPS	Uncharacterized protein. (512 aa)
	B8CAK5_THAPS	Lipoyl-binding domain-containing protein. (378 aa)
	B8CBX3_THAPS	2-oxoglutarate dehydrogenase E1 component. (1015 aa)
	SCS1	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (419 aa)
	THAPSDRAFT_795	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (337 aa)
	B8CEH1_THAPS	Acetyl-coa synthetase. (973 aa)
	B8CG06_THAPS	Uncharacterized protein. (373 aa)
	LPD	Dihydrolipoyl dehydrogenase. (470 aa)
	B8BS58_THAPS	Lipoyl-binding domain-containing protein. (307 aa)

Your Current Organism:

Thalassiosira pseudonana

NCBI taxonomy Id: 35128
Other names: T. pseudonana

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B8BS58_THAPS	B8BTA3_THAPS	B8BS58	B8BTA3	Lipoyl-binding domain-containing protein.	Alpha-keto acid dehydrogenase.	0.882
B8BS58_THAPS	B8BUT0_THAPS	B8BS58	B8BUT0	Lipoyl-binding domain-containing protein.	Transket_pyr domain-containing protein.	0.844
B8BS58_THAPS	B8C935_THAPS	B8BS58	B8C935	Lipoyl-binding domain-containing protein.	Uncharacterized protein.	0.533
B8BS58_THAPS	B8CBX3_THAPS	B8BS58	B8CBX3	Lipoyl-binding domain-containing protein.	2-oxoglutarate dehydrogenase E1 component.	0.987
B8BS58_THAPS	B8CEH1_THAPS	B8BS58	B8CEH1	Lipoyl-binding domain-containing protein.	Acetyl-coa synthetase.	0.680
B8BS58_THAPS	B8CG06_THAPS	B8BS58	B8CG06	Lipoyl-binding domain-containing protein.	Uncharacterized protein.	0.533
B8BS58_THAPS	LPD	B8BS58	B8LBI2	Lipoyl-binding domain-containing protein.	Dihydrolipoyl dehydrogenase.	0.875
B8BS58_THAPS	SCS1	B8BS58	B8BS06	Lipoyl-binding domain-containing protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.752
B8BS58_THAPS	SCS2	B8BS58	B8C013	Lipoyl-binding domain-containing protein.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.680
B8BS58_THAPS	THAPSDRAFT_795	B8BS58	B8CEA6	Lipoyl-binding domain-containing protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.844
B8BTA3_THAPS	B8BS58_THAPS	B8BTA3	B8BS58	Alpha-keto acid dehydrogenase.	Lipoyl-binding domain-containing protein.	0.882
B8BTA3_THAPS	B8BUT0_THAPS	B8BTA3	B8BUT0	Alpha-keto acid dehydrogenase.	Transket_pyr domain-containing protein.	0.979
B8BTA3_THAPS	B8C935_THAPS	B8BTA3	B8C935	Alpha-keto acid dehydrogenase.	Uncharacterized protein.	0.557
B8BTA3_THAPS	B8CAK5_THAPS	B8BTA3	B8CAK5	Alpha-keto acid dehydrogenase.	Lipoyl-binding domain-containing protein.	0.927
B8BTA3_THAPS	B8CBX3_THAPS	B8BTA3	B8CBX3	Alpha-keto acid dehydrogenase.	2-oxoglutarate dehydrogenase E1 component.	0.932
B8BTA3_THAPS	LPD	B8BTA3	B8LBI2	Alpha-keto acid dehydrogenase.	Dihydrolipoyl dehydrogenase.	0.981
B8BTA3_THAPS	SCS1	B8BTA3	B8BS06	Alpha-keto acid dehydrogenase.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.726
B8BTA3_THAPS	SCS2	B8BTA3	B8C013	Alpha-keto acid dehydrogenase.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.706
B8BTA3_THAPS	THAPSDRAFT_795	B8BTA3	B8CEA6	Alpha-keto acid dehydrogenase.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.999
B8BUT0_THAPS	B8BS58_THAPS	B8BUT0	B8BS58	Transket_pyr domain-containing protein.	Lipoyl-binding domain-containing protein.	0.844