(23 nodes) Pyrimidine metabolism network (Thalassiosira pseudonana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	THAPS_42740	dCMP deaminase. (176 aa)
	TMS1	Possible thymidylate synthase. (516 aa)
	THAPS_35527	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (559 aa)
	B8BQB6_THAPS	Uncharacterized protein. (296 aa)
	NDK3	Nucleoside diphosphate kinase. (151 aa)
	B8BRC9_THAPS	Uncharacterized protein. (324 aa)
	B8BUD4_THAPS	Thymidylate_kin domain-containing protein. (276 aa)
	B8BVT3_THAPS	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (244 aa)
	B8BWW6_THAPS	Uncharacterized protein. (335 aa)
	NDK4	Probable nuceloside diphosphate kinase. (396 aa)
	B8BYV0_THAPS	Probable uracil phosphoribosyltransferase. (232 aa)
	B8BZD2_THAPS	Uncharacterized protein. (335 aa)
	B8C055_THAPS	Uncharacterized protein; Belongs to the adenylate kinase family. (169 aa)
	RIR1_1	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (813 aa)
	RIR1_2	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (811 aa)
	B8C2V4_THAPS	Probable dUTP pyrophosphatase. (162 aa)
	B8C398_THAPS	Dihydroorotate dehydrogenase (fumarate); Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (325 aa)
	B8C5S9_THAPS	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (637 aa)
	NDK2	Nucleoside diphosphate kinase. (152 aa)
	PNP1	Probable purine-nucleoside phosphorylase. (241 aa)
	B8CAC1_THAPS	Uncharacterized protein. (275 aa)
	B8CDH4_THAPS	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (371 aa)
	NDK1	Nucleoside diphosphate kinase. (149 aa)

Your Current Organism:

Thalassiosira pseudonana

NCBI taxonomy Id: 35128
Other names: T. pseudonana

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B8BQB6_THAPS	B8BYV0_THAPS	B8BQB6	B8BYV0	Uncharacterized protein.	Probable uracil phosphoribosyltransferase.	0.900
B8BQB6_THAPS	B8CAC1_THAPS	B8BQB6	B8CAC1	Uncharacterized protein.	Uncharacterized protein.	0.900
B8BQB6_THAPS	PNP1	B8BQB6	B8C8W1	Uncharacterized protein.	Probable purine-nucleoside phosphorylase.	0.915
B8BRC9_THAPS	B8BVT3_THAPS	B8BRC9	B8BVT3	Uncharacterized protein.	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	0.908
B8BRC9_THAPS	B8BWW6_THAPS	B8BRC9	B8BWW6	Uncharacterized protein.	Uncharacterized protein.	0.900
B8BRC9_THAPS	B8BYV0_THAPS	B8BRC9	B8BYV0	Uncharacterized protein.	Probable uracil phosphoribosyltransferase.	0.905
B8BRC9_THAPS	B8BZD2_THAPS	B8BRC9	B8BZD2	Uncharacterized protein.	Uncharacterized protein.	0.900
B8BRC9_THAPS	B8C055_THAPS	B8BRC9	B8C055	Uncharacterized protein.	Uncharacterized protein; Belongs to the adenylate kinase family.	0.906
B8BRC9_THAPS	B8CAC1_THAPS	B8BRC9	B8CAC1	Uncharacterized protein.	Uncharacterized protein.	0.905
B8BRC9_THAPS	NDK1	B8BRC9	B8CGD4	Uncharacterized protein.	Nucleoside diphosphate kinase.	0.900
B8BRC9_THAPS	NDK2	B8BRC9	B8C642	Uncharacterized protein.	Nucleoside diphosphate kinase.	0.900
B8BRC9_THAPS	NDK3	B8BRC9	B8BQJ3	Uncharacterized protein.	Nucleoside diphosphate kinase.	0.900
B8BRC9_THAPS	NDK4	B8BRC9	B8BYR7	Uncharacterized protein.	Probable nuceloside diphosphate kinase.	0.900
B8BRC9_THAPS	RIR1_1	B8BRC9	B8C161	Uncharacterized protein.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.901
B8BRC9_THAPS	RIR1_2	B8BRC9	B8C1L6	Uncharacterized protein.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.900
B8BUD4_THAPS	B8BWW6_THAPS	B8BUD4	B8BWW6	Thymidylate_kin domain-containing protein.	Uncharacterized protein.	0.912
B8BUD4_THAPS	B8BZD2_THAPS	B8BUD4	B8BZD2	Thymidylate_kin domain-containing protein.	Uncharacterized protein.	0.912
B8BUD4_THAPS	B8C2V4_THAPS	B8BUD4	B8C2V4	Thymidylate_kin domain-containing protein.	Probable dUTP pyrophosphatase.	0.969
B8BUD4_THAPS	B8C398_THAPS	B8BUD4	B8C398	Thymidylate_kin domain-containing protein.	Dihydroorotate dehydrogenase (fumarate); Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.	0.512
B8BUD4_THAPS	B8C5S9_THAPS	B8BUD4	B8C5S9	Thymidylate_kin domain-containing protein.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.473