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| | Maqu_0090 | KEGG: abo:ABO_1281 isocitrate dehydrogenase (NADP-dependent); TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate dehydrogenase NADP-dependent, monomeric type; Belongs to the monomeric-type IDH family. (747 aa) |
| | Maqu_0257 | Transcriptional regulator, Fis family; Serine hydrolase involved in the detoxification of formaldehyde. (281 aa) |
| | Maqu_0301 | KEGG: aeh:Mlg_2122 phosphoenolpyruvate synthase. (862 aa) |
| | Maqu_0321 | PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: pau:PA14_17400 alcohol dehydrogenase class III; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (370 aa) |
| | mqo | Malate--quinone oxidoreductase; KEGG: mfa:Mfla_0011 malate dehydrogenase (acceptor); TIGRFAM: malate--quinone oxidoreductase; PFAM: FAD dependent oxidoreductase; Malate:quinone-oxidoreductase. (505 aa) |
| | pgi | PFAM: phosphoglucose isomerase (PGI); KEGG: hch:HCH_06266 glucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (130 aa) |
| | Maqu_0824 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); PFAM: malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: hch:HCH_05974 malic enzyme. (421 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (431 aa) |
| | serC | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (360 aa) |
| | Maqu_1058 | PFAM: fructose-bisphosphate aldolase, class-I; KEGG: net:Neut_1996 fructose-bisphosphate aldolase. (339 aa) |
| | Maqu_1120 | TIGRFAM: serine O-acetyltransferase; KEGG: hch:HCH_04463 serine O-acetyltransferase. (259 aa) |
| | Maqu_1132 | Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (717 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (401 aa) |
| | Maqu_1144 | 3-hydroxyacyl-CoA dehydrogenase / short chain enoyl-CoA hydratase; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (715 aa) |
| | Maqu_1149 | KEGG: hch:HCH_04750 citrate synthase I; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (424 aa) |
| | Maqu_1150 | TIGRFAM: fumarate reductase, D subunit; PFAM: succinate dehydrogenase, cytochrome b subunit; KEGG: hch:HCH_04749 succinate dehydrogenase (C subunit). (125 aa) |
| | Maqu_1151 | Succinate dehydrogenase subunit D; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (113 aa) |
| | Maqu_1152 | KEGG: hch:HCH_04747 succinate dehydrogenase, flavoprotein subunit; TIGRFAM: succinate dehydrogenase, flavoprotein subunit; succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (590 aa) |
| | Maqu_1153 | KEGG: hch:HCH_04746 succinate dehydrogenase, iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin. (234 aa) |
| | Maqu_1154 | TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: dehydrogenase, E1 component; Transketolase, central region; KEGG: hch:HCH_04745 2-oxoglutarate dehydrogenase, E1 component. (945 aa) |
| | Maqu_1155 | 2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (407 aa) |
| | Maqu_1156 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: hch:HCH_04743 dihydrolipoamide dehydrogenase. (480 aa) |
| | sucC | succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa) |
| | sucD | succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa) |
| | mqo-2 | Malate dehydrogenase (acceptor); PFAM: FAD dependent oxidoreductase; Malate:quinone-oxidoreductase; KEGG: oih:OB0946 malate:quinone oxidoreductase. (487 aa) |
| | accD | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (309 aa) |
| | Maqu_1581 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: hch:HCH_02661 phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein. (204 aa) |
| | Maqu_1594 | PFAM: MaoC domain protein dehydratase; KEGG: hch:HCH_02642 acyl dehydratase. (161 aa) |
| | glk | Glucokinase; KEGG: hch:HCH_00434 glucokinase; TIGRFAM: glucokinase; PFAM: Glucokinase; Belongs to the bacterial glucokinase family. (321 aa) |
| | edd | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (606 aa) |
| | Maqu_1831 | PFAM: pyruvate kinase; KEGG: hch:HCH_00431 pyruvate kinase; Belongs to the pyruvate kinase family. (482 aa) |
| | Maqu_1832 | KEGG: hch:HCH_00349 2-keto-3-deoxy-6-phosphogluconate aldolase; TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase. (215 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (237 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (304 aa) |
| | glcB | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (726 aa) |
| | Maqu_1859 | Aconitase; PFAM: aconitate hydratase domain protein; aconitate hydratase 2; KEGG: sde:Sde_1893 transcriptional regulator, XRE family; Belongs to the aconitase/IPM isomerase family. (869 aa) |
| | Maqu_1883 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (778 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (321 aa) |
| | Maqu_1932 | KEGG: hch:HCH_02684 glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (521 aa) |
| | Maqu_2016 | KEGG: pae:PA4785 probable acyl-CoA thiolase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (438 aa) |
| | Maqu_2035 | Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (504 aa) |
| | Maqu_2117 | KEGG: abo:ABO_0648 acetyl-CoA C-acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal domain protein; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa) |
| | Maqu_2133 | TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: aldehyde dehydrogenase; KEGG: ilo:IL0870 methylmalonate-semialdehyde dehydrogenase. (497 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (881 aa) |
| | Maqu_2251 | PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: shm:Shewmr7_2191 alcohol dehydrogenase, zinc-binding domain protein; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (375 aa) |
| | Maqu_2252 | Carboxylesterase; Serine hydrolase involved in the detoxification of formaldehyde. (283 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | pfp | Pyrophosphate-dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (420 aa) |
| | Maqu_2489 | acetyl-CoA acetyltransferase; KEGG: pau:PA14_42090 putative acyl-CoA thiolase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal domain protein; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa) |
| | Maqu_2490 | PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: hch:HCH_02185 3-hydroxyacyl-CoA dehydrogenase. (716 aa) |
| | Maqu_2696 | KEGG: abo:ABO_0648 acetyl-CoA C-acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | Maqu_2786 | KEGG: hch:HCH_05403 phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase, subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase, type 3. (410 aa) |
| | Maqu_2819 | D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: hch:HCH_01646 phosphoglycerate dehydrogenase and related dehydrogenase. (409 aa) |
| | Maqu_3037 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | pgk | PFAM: phosphoglycerate kinase; KEGG: hch:HCH_01537 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (386 aa) |
| | Maqu_3040 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (666 aa) |
| | Maqu_3044 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: hch:HCH_01531 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (289 aa) |
| | Maqu_3054 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: hch:HCH_01519 lactate dehydrogenase and related dehydrogenase. (311 aa) |
| | Maqu_3162 | KEGG: hch:HCH_01365 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa) |
| | gpmI | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (519 aa) |
| | Maqu_3252 | PFAM: pyruvate kinase; KEGG: mmc:Mmcs_0383 pyruvate kinase. (626 aa) |
| | Maqu_3327 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (552 aa) |
| | Maqu_3328 | 2-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa) |
| | mqo-3 | KEGG: hch:HCH_04006 malate:quinone-oxidoreductase; TIGRFAM: malate--quinone oxidoreductase; PFAM: FAD dependent oxidoreductase; Malate:quinone-oxidoreductase. (493 aa) |
| | fumC | Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (458 aa) |
| | ilvA | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (511 aa) |
| | rpiA | Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (225 aa) |
| | Maqu_3444 | Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (155 aa) |
| | Maqu_3445 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa) |
| | Maqu_3465 | PFAM: isocitrate lyase and phosphorylmutase; KEGG: abo:ABO_2741 isocitrate lyase. (530 aa) |
| | Maqu_3487 | Pyridine nucleotide-disulfide oxidoreductase dimerization region; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: hch:HCH_00152 putative pyridine nucleotide-disulfide oxidoreductase, class I. (479 aa) |
| | Maqu_3515 | PFAM: ribulose-phosphate 3-epimerase; KEGG: hch:HCH_06112 ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa) |
| | Maqu_3554 | PFAM: phosphoribulokinase/uridine kinase; KEGG: hch:HCH_06138 phosphoribulokinase. (288 aa) |
| | Maqu_3637 | KEGG: son:SO0538 glyceraldehyde 3-phosphate dehydrogenase; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa) |
| | Maqu_3674 | Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (920 aa) |
| | Maqu_3690 | TIGRFAM: cysteine synthases; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ppu:PP_4571 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (511 aa) |
| | Maqu_3860 | Formamidase; PFAM: Acetamidase/Formamidase; KEGG: abo:ABO_1978 formamidase. (410 aa) |
