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| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (275 aa) |
| | Maqu_0090 | KEGG: abo:ABO_1281 isocitrate dehydrogenase (NADP-dependent); TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate dehydrogenase NADP-dependent, monomeric type; Belongs to the monomeric-type IDH family. (747 aa) |
| | Maqu_0148 | Diaminobutyrate aminotransferase apoenzyme; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (422 aa) |
| | Maqu_0149 | PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; KEGG: noc:Noc_1029 aspartate kinase. (485 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: csa:Csal_3110 argininosuccinate lyase. (469 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (416 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (308 aa) |
| | metXS | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (382 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (277 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (345 aa) |
| | Maqu_0769 | KEGG: hch:HCH_01036 glutamine synthetase, type I; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp. (467 aa) |
| | ilvE | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa) |
| | metE | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (756 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (365 aa) |
| | Maqu_0834 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: hch:HCH_05965 glutamate synthase domain 2. (1482 aa) |
| | Maqu_0835 | TIGRFAM: glutamate synthase, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: hch:HCH_05964 NADPH-dependent glutamate synthase beta chain and related oxidoreductase. (472 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (361 aa) |
| | Maqu_0882 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: hch:HCH_05916 acetolactate synthase, large subunit, biosynthetic type. (572 aa) |
| | Maqu_0883 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: hch:HCH_05915 acetolactate synthase, small subunit. (163 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (431 aa) |
| | Maqu_0966 | Aspartate kinase; KEGG: hch:HCH_05208 asparate kinase, monofunctional class; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (412 aa) |
| | serC | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (360 aa) |
| | Maqu_1023 | TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase; amino acid-binding ACT domain protein; KEGG: csa:Csal_2166 chorismate mutase. (365 aa) |
| | hisC | Aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: pfo:Pfl_4075 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (374 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (742 aa) |
| | Maqu_1032 | PFAM: aminotransferase, class I and II; KEGG: hch:HCH_04972 aspartate/tyrosine/aromatic aminotransferase. (394 aa) |
| | Maqu_1058 | PFAM: fructose-bisphosphate aldolase, class-I; KEGG: net:Neut_1996 fructose-bisphosphate aldolase. (339 aa) |
| | Maqu_1120 | TIGRFAM: serine O-acetyltransferase; KEGG: hch:HCH_04463 serine O-acetyltransferase. (259 aa) |
| | Maqu_1149 | KEGG: hch:HCH_04750 citrate synthase I; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (424 aa) |
| | Maqu_1526 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1232 aa) |
| | Maqu_1545 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (359 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: pen:PSEEN1690 N-(5'-phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (209 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (371 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (357 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (215 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (472 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (364 aa) |
| | Maqu_1581 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: hch:HCH_02661 phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein. (204 aa) |
| | Maqu_1636 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II; asparagine synthase; KEGG: noc:Noc_2478 asparagine synthase, glutamine-hydrolyzing. (643 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (564 aa) |
| | Maqu_1772 | PFAM: aminotransferase, class I and II; KEGG: hch:HCH_02301 aspartate/tyrosine/aromatic aminotransferase. (404 aa) |
| | Maqu_1831 | PFAM: pyruvate kinase; KEGG: hch:HCH_00431 pyruvate kinase; Belongs to the pyruvate kinase family. (482 aa) |
| | Maqu_1859 | Aconitase; PFAM: aconitate hydratase domain protein; aconitate hydratase 2; KEGG: sde:Sde_1893 transcriptional regulator, XRE family; Belongs to the aconitase/IPM isomerase family. (869 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (321 aa) |
| | Maqu_1921 | 3-deoxy-7-phosphoheptulonate synthase; PFAM: DAHP synthetase I/KDSA; KEGG: hch:HCH_02697 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase. (375 aa) |
| | Maqu_1932 | KEGG: hch:HCH_02684 glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (521 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (169 aa) |
| | Maqu_2114 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: hch:HCH_06858 acetolactate synthase, large subunit, biosynthetic type. (565 aa) |
| | Maqu_2115 | KEGG: hch:HCH_06859 acetolactate synthase (isozyme II), small (regulatory) subunit. (92 aa) |
| | ilvD | KEGG: abo:ABO_0180 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (558 aa) |
| | Maqu_2240 | TIGRFAM: cysteine synthases; cysteine synthase B; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: hch:HCH_01805 cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. (297 aa) |
| | Maqu_2273 | KEGG: pae:PA3735 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (466 aa) |
| | Maqu_2274 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: pau:PA14_16070 homoserine dehydrogenase. (433 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (304 aa) |
| | Maqu_2345 | PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: mle:ML0354 acetolactate synthase large subunit. (552 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | pfp | Pyrophosphate-dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (420 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa) |
| | ilvD-2 | KEGG: pst:PSPTO_5057 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (611 aa) |
| | argJ | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (405 aa) |
| | leuA-2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (516 aa) |
| | Maqu_2551 | PFAM: aminotransferase, class I and II; KEGG: pae:PA3659 N-succinyldiaminopimelate aminotransferase. (400 aa) |
| | dapD | Tetrahydrodipicolinate succinylase, putative; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (342 aa) |
| | dapE | Succinyldiaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (376 aa) |
| | argG | PFAM: argininosuccinate synthase; ExsB family protein; KEGG: csa:Csal_2127 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (403 aa) |
| | hisC-2 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: pfo:Pfl_0872 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (353 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (214 aa) |
| | hisZ | tRNA synthetase, class II (G, H, P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (393 aa) |
| | Maqu_2786 | KEGG: hch:HCH_05403 phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase, subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase, type 3. (410 aa) |
| | Maqu_2819 | D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: hch:HCH_01646 phosphoglycerate dehydrogenase and related dehydrogenase. (409 aa) |
| | Maqu_3037 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | pgk | PFAM: phosphoglycerate kinase; KEGG: hch:HCH_01537 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (386 aa) |
| | Maqu_3040 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (666 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (396 aa) |
| | Maqu_3063 | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (452 aa) |
| | gpmI | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (519 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: hch:HCH_01346 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (245 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (213 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pau:PA14_67930 imidazoleglycerol-phosphate dehydratase. (197 aa) |
| | Maqu_3252 | PFAM: pyruvate kinase; KEGG: mmc:Mmcs_0383 pyruvate kinase. (626 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (267 aa) |
| | Maqu_3397 | PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: hch:HCH_02178 thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. (556 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (138 aa) |
| | hisE | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: hch:HCH_01078 phosphoribosyl-ATP pyrophosphohydrolase. (109 aa) |
| | ilvA | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (511 aa) |
| | rpiA | Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (225 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa) |
| | Maqu_3489 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (350 aa) |
| | Maqu_3500 | PFAM: aminotransferase, class I and II; KEGG: aeh:Mlg_2554 aminotransferase, class I and II. (431 aa) |
| | Maqu_3515 | PFAM: ribulose-phosphate 3-epimerase; KEGG: hch:HCH_06112 ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa) |
| | trpE | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (495 aa) |
| | Maqu_3518 | Anthranilate synthase, component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: hch:HCH_06126 anthranilate/para-aminobenzoate synthases component II. (192 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (342 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: pae:PA0651 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (270 aa) |
| | argA | N-acetylglutamate synthase; TIGRFAM: amino-acid N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase; aspartate/glutamate/uridylate kinase; KEGG: ppu:PP_5185 N-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. (435 aa) |
| | Maqu_3558 | TIGRFAM: acetylornithine deacetylase (ArgE); PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: pfl:PFL_5942 acetylornithine deacetylase. (387 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (290 aa) |
| | Maqu_3637 | KEGG: son:SO0538 glyceraldehyde 3-phosphate dehydrogenase; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa) |
| | Maqu_3674 | Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (920 aa) |
| | Maqu_3690 | TIGRFAM: cysteine synthases; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ppu:PP_4571 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa) |
| | Maqu_3806 | PFAM: aminotransferase, class I and II; KEGG: mca:MCA1021 aminotransferase, classes I and II. (393 aa) |
