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purU purU proC proC Acel_0248 Acel_0248 Acel_0637 Acel_0637 Acel_0703 Acel_0703 proB proB proA proA Acel_0919 Acel_0919 Acel_0923 Acel_0923 Acel_1078 Acel_1078 Acel_1079 Acel_1079 Acel_1096 Acel_1096 gcvP gcvP gcvH gcvH glyA glyA Acel_1749 Acel_1749 Acel_1750 Acel_1750 Acel_1846 Acel_1846 gcvT gcvT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (283 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (276 aa)
Acel_0248PFAM: Proline dehydrogenase; KEGG: tfu:Tfu_0434 proline dehydrogenase. (317 aa)
Acel_0637PFAM: protein of unknown function DUF201; KEGG: cac:CAC2189 hypothetical protein. (484 aa)
Acel_0703PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; 4Fe-4S ferredoxin, iron-sulfur binding domain protein; FAD dependent oxidoreductase; KEGG: rfr:Rfer_2184 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate. (543 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (393 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (445 aa)
Acel_0919L-glutamine synthetase; KEGG: sco:SCO2241 probable glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp. (453 aa)
Acel_0923L-glutamine synthetase; KEGG: sma:SAV6005 putative glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp. (474 aa)
Acel_1078PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: fra:Francci3_3013 glutamate synthase (ferredoxin). (1513 aa)
Acel_1079TIGRFAM: glutamate synthases, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: tfu:Tfu_1174 glutamate synthase, NADH/NADPH, small subunit 1. (486 aa)
Acel_1096PFAM: glutamine synthetase, catalytic region; KEGG: mja:MJ1346 glutamine synthetase (GlnA). (449 aa)
gcvPGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (964 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (130 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (427 aa)
Acel_1749PFAM: NAD-glutamate dehydrogenase; KEGG: sma:SAV5075 NAD-glutamate dehydrogenase. (1584 aa)
Acel_1750TIGRFAM: delta-1-pyrroline-5-carboxylate dehydrogenase; PFAM: aldehyde dehydrogenase; KEGG: tfu:Tfu_0433 delta-1-pyrroline-5-carboxylate dehydrogenase 1; Belongs to the aldehyde dehydrogenase family. (544 aa)
Acel_1846KEGG: cvi:CV2874 L-serine dehydratase; TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (386 aa)
Your Current Organism:
Acidothermus cellulolyticus
NCBI taxonomy Id: 351607
Other names: A. cellulolyticus 11B, Acidothermus cellulolyticus 11B, Acidothermus cellulolyticus str. 11B, Acidothermus cellulolyticus strain 11B
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