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| | Acel_0029 | PFAM: FAD dependent oxidoreductase; KEGG: sco:SCO1661 putative glycerol-3-phosphate dehydrogenase. (555 aa) |
| | Acel_0031 | PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: sco:SCO3815 putative dihydrolipoamide acyltransferase component. (546 aa) |
| | Acel_0033 | PFAM: dehydrogenase, E1 component; KEGG: tfu:Tfu_0180 pyruvate dehydrogenase (lipoamide). (372 aa) |
| | Acel_0039 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; 3-demethylubiquinone-9 3-methyltransferase; KEGG: tbd:Tbd_1204 PhnB protein. (143 aa) |
| | thiC | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (585 aa) |
| | gpmA | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (252 aa) |
| | Acel_0080 | PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; KEGG: fra:Francci3_4254 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase. (243 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (161 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (224 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (283 aa) |
| | Acel_0167 | Molybdopterin molybdochelatase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (414 aa) |
| | moaC | GTP cyclohydrolase subunit MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (158 aa) |
| | Acel_0169 | TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; KEGG: tfu:Tfu_0376 molybdopterin binding domain. (170 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (332 aa) |
| | Acel_0203 | KEGG: tfu:Tfu_2896 hypoxanthine phosphoribosyl transferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (184 aa) |
| | folE | PFAM: GTP cyclohydrolase I; KEGG: tfu:Tfu_2894 GTP cyclohydrolase I. (200 aa) |
| | Acel_0213 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (548 aa) |
| | Acel_0214 | KEGG: sco:SCO3381 nicotinate-nucleotide pyrophophorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (311 aa) |
| | coaX | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (256 aa) |
| | Acel_0232 | PFAM: phosphoesterase; KEGG: sma:SAV5971 secreted acid phosphatase. (260 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | nnrE | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] (495 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (516 aa) |
| | Acel_0367 | TIGRFAM: IMP dehydrogenase family protein; KEGG: tfu:Tfu_2595 IMP dehydrogenase related 2. (369 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (522 aa) |
| | purN | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (202 aa) |
| | purH | KEGG: tfu:Tfu_2572 AICARFT/IMPCHase bienzyme; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme; MGS domain protein. (531 aa) |
| | folD | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (293 aa) |
| | Acel_0387 | Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. (330 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (399 aa) |
| | purE | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (176 aa) |
| | Acel_0410 | PFAM: thioesterase superfamily protein; KEGG: sco:SCO3049 acyl-CoA hydrolase. (171 aa) |
| | Acel_0455 | LPPG:FO 2-phospho-L-lactate transferase; TIGRFAM: LPPG; PFAM: protein of unknown function UPF0052 and CofD; KEGG: tfu:Tfu_2517 LPPG:Fo 2-phospho-L-lactate transferase. (390 aa) |
| | Acel_0472 | PFAM: molybdopterin biosynthesis MoaE; KEGG: fra:Francci3_3785 molybdopterin biosynthesis MoaE. (157 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (344 aa) |
| | Acel_0533 | PFAM: inositol monophosphatase; KEGG: nfa:nfa44910 putative monophosphatase. (265 aa) |
| | Acel_0561 | PFAM: diacylglycerol kinase, catalytic region; KEGG: sco:SCO5241 hypothetical protein. (342 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (235 aa) |
| | Acel_0588 | Catalytic domain of components of various dehydrogenase complexes; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (449 aa) |
| | pdhA | Pyruvate dehydrogenase (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (375 aa) |
| | Acel_0637 | PFAM: protein of unknown function DUF201; KEGG: cac:CAC2189 hypothetical protein. (484 aa) |
| | atpB | ATP synthase F0 subcomplex A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (271 aa) |
| | atpE | ATP synthase F0 subcomplex C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (87 aa) |
| | atpF | ATP synthase F0 subcomplex B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (191 aa) |
| | atpH | ATP synthase F1 subcomplex delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (274 aa) |
| | atpA | ATP synthase F1 subcomplex alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (554 aa) |
| | atpG | ATP synthase F1 subcomplex gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (300 aa) |
| | atpD | ATP synthase F1 subcomplex beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (490 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (125 aa) |
| | Acel_0665 | KEGG: fra:Francci3_3490 molybdopterin-guanine dinucleotide biosynthesis protein A-like. (242 aa) |
| | Acel_0666 | Hypothetical protein; KEGG: sco:SCO3828 molybdopterin-guanine dinucleotide biosynthesis protein. (94 aa) |
| | fdhD | Formate dehydrogenase, subunit FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (320 aa) |
| | Acel_0716 | PFAM: phosphoribulokinase/uridine kinase; KEGG: rfr:Rfer_2550 hypothetical protein. (213 aa) |
| | Acel_0721 | PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: sto:ST2350 hypothetical protein. (283 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (208 aa) |
| | Acel_0788 | PFAM: histidine triad (HIT) protein; KEGG: tfu:Tfu_0843 putative protein kinase C inhibitor (HIT family. (113 aa) |
| | Acel_0802 | KEGG: tfu:Tfu_0865 deoxyguanosinetriphosphate triphosphohydrolase; TIGRFAM: putative deoxyguanosinetriphosphate triphosphohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region; Belongs to the dGTPase family. Type 2 subfamily. (468 aa) |
| | Acel_0817 | KEGG: noc:Noc_0064 hypothetical protein. (677 aa) |
| | Acel_0844 | Type III secretion system ATPase, FliI/YscN; KEGG: lxx:Lxx06360 flagellum-like ATP synthase; TIGRFAM: ATPase, FliI/YscN family; flagellar protein export ATPase FliI; PFAM: H+-transporting two-sector ATPase, alpha/beta subunit, central region; H+-transporting two-sector ATPase, alpha/beta subunit domain protein; SMART: AAA ATPase. (439 aa) |
| | araB | TIGRFAM: L-ribulokinase; PFAM: carbohydrate kinase, FGGY; KEGG: bsu:BG11905 L-ribulokinase. (564 aa) |
| | araA | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (501 aa) |
| | nadE | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (591 aa) |
| | Acel_0935 | 2-oxoglutarate dehydrogenase E2 component; PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: fra:Francci3_3135 dehydrogenase subunit. (476 aa) |
| | Acel_0982 | PFAM: phospholipid/glycerol acyltransferase; KEGG: tfu:Tfu_1036 phospholipid/glycerol acyltransferase. (266 aa) |
| | pfp | Pyrophosphate-dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (341 aa) |
| | thiG | Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (262 aa) |
| | Acel_0988 | TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: tfu:Tfu_1043 ThiS, thiamine-biosynthesis. (67 aa) |
| | Acel_0989 | TIGRFAM: glycine oxidase ThiO; PFAM: FAD dependent oxidoreductase; KEGG: sma:SAV6095 putative glycine oxidase. (404 aa) |
| | thiE | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (212 aa) |
| | Acel_1017 | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: fra:Francci3_4498 oxidoreductase FAD/NAD(P)-binding. (249 aa) |
| | Acel_1046 | Pyruvate dehydrogenase (acetyl-transferring); PFAM: dehydrogenase, E1 component; KEGG: bha:BH0776 acetoin dehydrogenase (TPP-dependent) alpha chain. (342 aa) |
| | Acel_1048 | PFAM: biotin/lipoyl attachment domain-containing protein; KEGG: pac:PPA0693 dihydrolipoamide acyltransferase. (76 aa) |
| | Acel_1068 | PFAM: AMP-dependent synthetase and ligase; KEGG: sru:SRU_1684 acetyl-CoA synthase. (713 aa) |
| | Acel_1080 | PFAM: pyruvate kinase; KEGG: sma:SAV6217 putative pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (224 aa) |
| | Acel_1094 | PFAM: glutamine amidotransferase class-I; KEGG: tel:tll1969 probable amino transferase. (238 aa) |
| | Acel_1114 | KEGG: tfu:Tfu_2017 glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa) |
| | pgk | Phosphoglycerate kinase / triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (687 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (254 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (508 aa) |
| | Acel_1125 | PFAM: phosphoglucose isomerase (PGI); KEGG: tfu:Tfu_2004 glucose-6-phosphate isomerase; Belongs to the GPI family. (542 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (372 aa) |
| | Acel_1127 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (692 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (326 aa) |
| | Acel_1185 | PFAM: NUDIX hydrolase; KEGG: sma:SAV6619 NTP pyrophosphohydrolase. (187 aa) |
| | Acel_1232 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: tfu:Tfu_1393 putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (216 aa) |
| | cmk | Cytidylate kinase; KEGG: nfa:nfa20120 putative cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. (255 aa) |
| | Acel_1242 | PFAM: NUDIX hydrolase; KEGG: sco:SCO1775 hypothetical protein. (216 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (558 aa) |
| | Acel_1244 | KEGG: mpa:MAP1404 hypothetical protein. (407 aa) |
| | nadK | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (296 aa) |
| | Acel_1276 | PFAM: ribulose-phosphate 3-epimerase; KEGG: tfu:Tfu_1077 ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (229 aa) |
| | Acel_1291 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (415 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (208 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (238 aa) |
| | pyrD | Dihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (351 aa) |
| | Acel_1297 | Dihydroorotate oxidase B, electron transfer subunit; PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: tfu:Tfu_1058 dihydroorotate dehydrogenase electron transfer subunit. (297 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: tfu:Tfu_1057 carbamoyl-phosphate synthase, large subunit, glutamine-dependent; Belongs to the CarB family. (1093 aa) |
| | carA | KEGG: sma:SAV6866 putative carbamoyl-phosphate synthase subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase, small chain; Belongs to the CarA family. (395 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (428 aa) |
| | pyrB | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; KEGG: sco:SCO1487 aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (323 aa) |
| | Acel_1338 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (820 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (177 aa) |
| | pdxT | Pyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (207 aa) |
| | pdxS | Pyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (322 aa) |
| | Acel_1355 | CDP-diacylglycerol inositol 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: tfu:Tfu_2103 putative membrane transferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (248 aa) |
| | Acel_1357 | PFAM: histidine triad (HIT) protein; KEGG: sma:SAV6823 HIT family protein. (250 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (633 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (171 aa) |
| | Acel_1405 | PFAM: inositol monophosphatase; KEGG: tfu:Tfu_1943 inositol-1(or 4)-monophosphatase. (282 aa) |
| | Acel_1497 | TIGRFAM: competence/damage-inducible protein CinA; PFAM: molybdopterin binding domain; CinA domain protein; KEGG: fra:Francci3_3538 competence-damaged protein; Belongs to the CinA family. (427 aa) |
| | Acel_1498 | TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: fra:Francci3_3539 CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (220 aa) |
| | thyX | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (243 aa) |
| | Acel_1511 | FMN adenylyltransferase; TIGRFAM: riboflavin biosynthesis protein RibF; cytidyltransferase-related domain; PFAM: Riboflavin kinase / FAD synthetase; KEGG: sma:SAV2546 putative riboflavin kinase; Belongs to the ribF family. (337 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (391 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (421 aa) |
| | Acel_1531 | PFAM: amino acid-binding ACT domain protein; KEGG: fra:Francci3_3646 amino acid-binding ACT. (211 aa) |
| | Acel_1533 | PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; KEGG: gka:GK0081 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase. (240 aa) |
| | Acel_1538 | PFAM: phosphatidate cytidylyltransferase; KEGG: sma:SAV2623 putative phosphatidate cytidylyltransferase; Belongs to the CDS family. (291 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (266 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (165 aa) |
| | Acel_1583 | KEGG: sco:SCO5563 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (264 aa) |
| | thiL | Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (300 aa) |
| | gpsA | PFAM: NADP oxidoreductase, coenzyme F420-dependent; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; Ketopantoate reductase ApbA/PanE, N-terminal domain protein; KEGG: sma:SAV2680 putative glycerol-3-phosphate dehydrogenase, NAD(P)H-dependent. (365 aa) |
| | Acel_1588 | PFAM: phospholipid/glycerol acyltransferase; KEGG: tfu:Tfu_0630 phospholipid/glycerol acyltransferase. (255 aa) |
| | moaA | GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (362 aa) |
| | folE-2 | PFAM: GTP cyclohydrolase I; KEGG: nfa:nfa31470 putative GTP cyclohydrolase I. (212 aa) |
| | Acel_1683 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (211 aa) |
| | Acel_1692 | Putative nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (443 aa) |
| | Acel_1696 | PFAM: Polyprenyl synthetase; KEGG: fra:Francci3_0822 polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (339 aa) |
| | Acel_1704 | PFAM: protein of unknown function DUF179; KEGG: sco:SCO2948 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (208 aa) |
| | Acel_1714 | TIGRFAM: acetoacetyl-CoA synthase; PFAM: AMP-dependent synthetase and ligase; KEGG: bms:BR0021 acetoacetyl-CoA synthase. (687 aa) |
| | Acel_1717 | PFAM: isochorismatase hydrolase; KEGG: pac:PPA0993 pyrazinamidase/nicotinamidase. (207 aa) |
| | Acel_1725 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (348 aa) |
| | Acel_1802 | KEGG: sma:SAV5339 hypothetical protein. (291 aa) |
| | Acel_1820 | TIGRFAM: 6-phosphogluconate dehydrogenase, decarboxylating; PFAM: 6-phosphogluconate dehydrogenase domain protein; 6-phosphogluconate dehydrogenase, NAD-binding; KEGG: mpa:MAP2670c 6-phosphogluconate dehydrogenase. (344 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (340 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa) |
| | Acel_1910 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: fra:Francci3_3928 MazG family protein. (229 aa) |
| | Acel_1935 | KEGG: tte:TTE0666 acetyltransferase (the isoleucine patch superfamily). (227 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (325 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (505 aa) |
| | fbiD | Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. (260 aa) |
| | Acel_1962 | Coenzyme F420-0 gamma-glutamyl ligase; TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: nitroreductase; protein of unknown function DUF129; KEGG: sco:SCO3037 putative oxidoreductase. (430 aa) |
| | Acel_1965 | KEGG: hch:HCH_05713 hypothetical protein. (600 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (688 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (657 aa) |
| | Acel_1991 | PFAM: NUDIX hydrolase; KEGG: tfu:Tfu_0119 hypothetical protein. (213 aa) |
| | Acel_2006 | PFAM: metallophosphoesterase; KEGG: mbo:Mb3708 hypothetical protein. (299 aa) |
| | Acel_2024 | PFAM: thiamineS protein; KEGG: fra:Francci3_0445 thiamine S. (92 aa) |
| | Acel_2034 | Integral membrane protein-like protein; KEGG: fra:Francci3_4524 hypothetical protein. (520 aa) |
| | Acel_2043 | Hypothetical protein. (108 aa) |
| | Acel_2044 | PFAM: NUDIX hydrolase; KEGG: mpa:MAP0346c hypothetical protein. (160 aa) |
| | Acel_2055 | PFAM: thiamineS protein; nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; KEGG: pai:PAE2577 ferredoxin-nitrite reductase. (639 aa) |
| | purM | KEGG: sco:SCO4087 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (350 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (506 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (754 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (225 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (81 aa) |
| | Acel_2080 | KEGG: nfa:nfa49830 hypothetical protein. (260 aa) |
| | dcd | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (196 aa) |
| | Acel_2125 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (342 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa) |
| | purD | Phosphoribosylamine--glycine ligase; KEGG: tfu:Tfu_3013 phosphoribosylglycinamide synthetase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; Belongs to the GARS family. (420 aa) |
| | Acel_2128 | KEGG: sma:SAV7077 putative adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (475 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: sma:SAV4146 putative phosphoribosylaminoimidazole-succinocar boxamide synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (284 aa) |
| | Acel_2138 | PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase, GAPDH domain protein; KEGG: tfu:Tfu_3099 myo-inositol-1-phosphate synthase. (359 aa) |
