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papC papC cysG cysG hemF hemF XDD1_2720 XDD1_2720 fabI fabI xcnE xcnE pyrD pyrD dusC dusC sdhA sdhA wecC wecC XDD1_0414 XDD1_0414 XDD1_0415 XDD1_0415 dapB dapB ACADL ACADL hpaB hpaB yggW yggW fadE fadE tyrA tyrA sdhC sdhC sdhD sdhD hemG hemG dusA dusA fadH fadH dusB dusB frdA frdA frdB frdB frdC frdC frdD frdD hemN hemN
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
papCSimilar to dehydrogenase papc of streptomyces pristinaespiralis. (293 aa)
cysGSiroheme synthase [Includes: Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (463 aa)
hemFCoproporphyrinogen-III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (302 aa)
XDD1_2720Acyl-CoA dehydrogenase. (387 aa)
fabIEnoyl-[acyl-carrier-protein] reductase [NADH]. (262 aa)
xcnEAcyl-CoA dehydrogenase involved in xenocoumacin synthesis; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (383 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa)
dusCtRNA-dihydrouridine synthase C; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. (329 aa)
sdhASuccinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
wecCUDP-N-acetyl-D-mannosamine dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa)
XDD1_0414Homologs of previously reported genes of unknown function. (409 aa)
XDD1_04154-hydroxyphenylacetate 3-monooxygenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (477 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
ACADLLong-chain specific acyl-CoA dehydrogenase, mitochondrial. (378 aa)
hpaB4-hydroxyphenylacetate 3-monooxygenase oxygenase component; Function of strongly homologous gene; enzyme. (520 aa)
yggWOxygen-independent coproporphyrinogen-III oxidase-like protein yggW; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (376 aa)
fadEAcyl-coenzyme A dehydrogenase. (815 aa)
tyrABifunctional: chorismate mutase T (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (373 aa)
sdhCSuccinate dehydrogenase cytochrome b556 subunit. (129 aa)
sdhDSuccinate dehydrogenase hydrophobic membrane anchor subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
hemGProtoporphyrinogen IX dehydrogenase [menaquinone]. (180 aa)
dusAtRNA-dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. (342 aa)
fadH2,4-dienoyl-CoA reductase [NADPH]. (673 aa)
dusBtRNA-dihydrouridine synthase B; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. (327 aa)
frdAFumarate reductase flavoprotein subunit. (598 aa)
frdBFumarate reductase iron-sulfur subunit. (250 aa)
frdCFumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (131 aa)
frdDFumarate reductase subunit D; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (117 aa)
hemNOxygen-independent coproporphyrinogen-III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (457 aa)
Your Current Organism:
Xenorhabdus doucetiae
NCBI taxonomy Id: 351671
Other names: CIP 109074, DSM 17909, X. doucetiae, Xenorhabdus doucetiae Tailliez et al. 2006, Xenorhabdus sp. FRG30, strain FRM16
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