STRINGSTRING
XDD1_1974 XDD1_1974 XDD1_0084 XDD1_0084 XDD1_0085 XDD1_0085 paaX paaX coaBC coaBC tdh tdh XDD1_0412 XDD1_0412 tnaA tnaA XDD1_0415 XDD1_0415 XDD1_0523 XDD1_0523 XDD1_0565 XDD1_0565 XDD1_0584 XDD1_0584 yjeK yjeK feaB feaB XDD1_0685 XDD1_0685 XDD1_0763 XDD1_0763 tesC tesC XDD1_0935 XDD1_0935 XDD1_1010 XDD1_1010 hpaB hpaB hpaI hpaI gabD gabD hpaE hpaE hpaG2 hpaG2 hpaG1 hpaG1 XDD1_1030 XDD1_1030 iolA iolA fadE fadE betB betB XDD1_1286 XDD1_1286 nagB nagB XDD1_1655 XDD1_1655 xcnB xcnB XDD1_1845 XDD1_1845 anmK anmK XDD1_1920 XDD1_1920 dgoK dgoK dgoA dgoA dgoD dgoD XDD1_1967 XDD1_1967 XDD1_1986 XDD1_1986 XDD1_2091 XDD1_2091 dadA dadA putA putA hinT hinT mtr mtr fadI fadI fadJ fadJ hutI hutI hutG hutG hutU hutU hutH hutH astA astA astD astD astB astB astE astE XDD1_2685 XDD1_2685 hbd hbd grcA grcA prpR prpR prpB prpB gcvP gcvP gcvH gcvH gcvT gcvT aldA aldA speA speA fadB fadB fadA fadA fadH fadH XDD1_3627 XDD1_3627 slyX slyX murQ murQ XDD1_3799 XDD1_3799 dtd dtd paaZ paaZ paaA paaA paaB paaB paaC paaC paaD paaD paaE paaE paaG paaG paaH paaH paaI paaI paaJ paaJ paaK paaK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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XDD1_1974Dimethylmenaquinone methyltransferase. (217 aa)
XDD1_0084Putative AMP-dependent synthetase/ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (414 aa)
XDD1_0085Putative Long-chain-fatty-acyl-CoA reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (821 aa)
paaXPhenylacetic acid degradation operon negative regulatory protein paaX. (315 aa)
coaBCCoenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (414 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa)
XDD1_0412Homologs of previously reported genes of unknown function. (234 aa)
tnaATryptophanase. (467 aa)
XDD1_04154-hydroxyphenylacetate 3-monooxygenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (477 aa)
XDD1_0523Homologs of previously reported genes of unknown function. (408 aa)
XDD1_0565Cyclase family protein; Function of strongly homologous gene; enzyme. (261 aa)
XDD1_0584Homologs of previously reported genes of unknown function. (303 aa)
yjeKUncharacterized KamA family protein YjeK. (342 aa)
feaBProtein FeaB, Phenylacetaldehyde dehydrogenase; Function of strongly homologous gene; enzyme; Belongs to the aldehyde dehydrogenase family. (497 aa)
XDD1_0685Homologs of previously reported genes of unknown function. (425 aa)
XDD1_0763Phosphopantothenoylcysteine decarboxylase (flavoprotein); Function of strongly homologous gene; enzyme. (195 aa)
tesCLong-chain acyl-CoA thioesterase tesC. (135 aa)
XDD1_0935Protein of unknown function; No homology to any previously reported sequences. (325 aa)
XDD1_1010Putative N-acetyl-gamma-glutamyl-phosphate reductase (fragment); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (337 aa)
hpaB4-hydroxyphenylacetate 3-monooxygenase oxygenase component; Function of strongly homologous gene; enzyme. (520 aa)
hpaI4-hydroxy-2-oxo-heptane-1,7-dioate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the HpcH/HpaI aldolase family. (255 aa)
gabDSuccinate-semialdehyde dehydrogenase, NADP-dependent; Function of strongly homologous gene; enzyme; Belongs to the aldehyde dehydrogenase family. (495 aa)
hpaE5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aldehyde dehydrogenase family. (488 aa)
hpaG2HpaG2 protein, 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase component; Function of strongly homologous gene; enzyme. (254 aa)
hpaG1HpaG1 protein, 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase component; Function of strongly homologous gene; enzyme. (210 aa)
XDD1_1030Putative short chain dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (255 aa)
iolAMethylmalonate semialdehyde dehydrogenase [acylating] 2. (503 aa)
fadEAcyl-coenzyme A dehydrogenase. (815 aa)
betBBetaine aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. (492 aa)
XDD1_1286Homologs of previously reported genes of unknown function. (78 aa)
nagBGlucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (268 aa)
XDD1_1655Acetyl-CoA C-acyltransferase (fragment). (89 aa)
xcnB3-hydroxyacyl-CoA dehydrogenase involved in xenocoumacin synthesis; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (285 aa)
XDD1_1845Homologs of previously reported genes of unknown function. (1024 aa)
anmKAnhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (369 aa)
XDD1_1920Gamma-aminobutyraldehyde dehydrogenase; Function of strongly homologous gene; enzyme; Belongs to the aldehyde dehydrogenase family. (476 aa)
dgoK2-dehydro-3-deoxygalactonokinase. (297 aa)
dgoA2-dehydro-3-deoxy-6-phosphogalactonate aldolase. (205 aa)
dgoDD-galactonate dehydratase; Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy- D-galactonate. (382 aa)
XDD1_1967Achromobactin biosynthetic protein AcsB; Belongs to the HpcH/HpaI aldolase family. (258 aa)
XDD1_1986Homologs of previously reported genes of unknown function. (396 aa)
XDD1_2091Homologs of previously reported genes of unknown function. (218 aa)
dadAD-amino acid dehydrogenase small subunit; Oxidative deamination of D-amino acids. (433 aa)
putABifunctional protein putA [Includes: Proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1326 aa)
hinTHIT-like protein hinT. (116 aa)
mtrTryptophan-specific transport protein. (414 aa)
fadI3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (436 aa)
fadJEnoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (732 aa)
hutIImidazolonepropionase. (415 aa)
hutGFormimidoylglutamase; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family. (319 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (564 aa)
hutHHistidine ammonia-lyase. (510 aa)
astAArginine N-succinyltransferase. (343 aa)
astDN-succinylglutamate 5-semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. (498 aa)
astBN-succinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2). (447 aa)
astESuccinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. (339 aa)
XDD1_2685Monooxygenase FAD-binding (fragment). (497 aa)
hbdPutative 3-hydroxybutyryl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (283 aa)
grcAAutonomous glycyl radical cofactor; Acts as a radical domain for damaged PFL and possibly other radical proteins. (127 aa)
prpRPropionate catabolism operon regulatory protein. (560 aa)
prpBMethylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (301 aa)
gcvPMethyltransferase type 12 (fragment); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (958 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (130 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (366 aa)
aldAPutative aldehyde dehydrogenase AldA; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the aldehyde dehydrogenase family. (494 aa)
speABiosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (634 aa)
fadBEnoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (728 aa)
fadA3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (387 aa)
fadH2,4-dienoyl-CoA reductase [NADPH]. (673 aa)
XDD1_3627Putative L-iditol 2-dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (353 aa)
slyXProtein slyX; Belongs to the SlyX family. (72 aa)
murQN-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. (302 aa)
XDD1_3799Homologs of previously reported genes of unknown function. (429 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (145 aa)
paaZProtein of unknown function (fragment); No homology to any previously reported sequences. (690 aa)
paaAProtein PaaA; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (314 aa)
paaBProtein PaaB; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (95 aa)
paaCProtein PaaC; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (263 aa)
paaDProtein PaaD; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (177 aa)
paaEProteon PaaE; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (367 aa)
paaGProtein PaaG; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (265 aa)
paaHProtein PaaH; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (547 aa)
paaIProetein PaaI; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (150 aa)
paaJProtein PaaJ; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
paaKProtein PaaK; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (442 aa)
Your Current Organism:
Xenorhabdus doucetiae
NCBI taxonomy Id: 351671
Other names: CIP 109074, DSM 17909, X. doucetiae, Xenorhabdus doucetiae Tailliez et al. 2006, Xenorhabdus sp. FRG30, strain FRM16
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