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KLU16849.1 KLU16849.1 KLU17374.1 KLU17374.1 cyaA cyaA KLU17426.1 KLU17426.1 nudE nudE KLU17312.1 KLU17312.1 KLU17314.1 KLU17314.1 KLU17105.1 KLU17105.1 KLU17106.1 KLU17106.1 apaH apaH KLU17049.1 KLU17049.1 nudF nudF rihB rihB KLU16950.1 KLU16950.1 deoD deoD KLU16974.1 KLU16974.1 KLU16994.1 KLU16994.1 ushA ushA KLU16918.1 KLU16918.1 adk adk KLU16867.1 KLU16867.1 KLU16872.1 KLU16872.1 KLU16896.1 KLU16896.1 cpdB cpdB KLU16813.1 KLU16813.1 truA truA KLU16758.1 KLU16758.1 KLU16717.1 KLU16717.1 ychF ychF KLU16547.1 KLU16547.1 KLU16574.1 KLU16574.1 KLU16575.1 KLU16575.1 purN purN KLU16579.1 KLU16579.1 ihfB ihfB relA relA mazG mazG guaA guaA KLU16327.1 KLU16327.1 KLU16337.1 KLU16337.1 KLU16344.1 KLU16344.1 KLU16037.1 KLU16037.1 KLU16083.1 KLU16083.1 KLU16084.1 KLU16084.1 tilS tilS KLU15674.1 KLU15674.1 cysN cysN KLU15676.1 KLU15676.1 surE surE KLU15694.1 KLU15694.1 KLU15615.1 KLU15615.1 KLU15616.1 KLU15616.1 KLU15391.1 KLU15391.1 KLU15289.1 KLU15289.1 KLU15241.1 KLU15241.1 KLU15246.1 KLU15246.1 KLU15207.1 KLU15207.1 KLU15104.1 KLU15104.1 KLU14994.1 KLU14994.1 purE purE KLU14842.1 KLU14842.1 KLU14791.1 KLU14791.1 KLU14792.1 KLU14792.1 KLU14640.1 KLU14640.1 purH purH KLU14571.1 KLU14571.1 KLU14572.1 KLU14572.1 KLU14454.1 KLU14454.1 KLU14365.1 KLU14365.1 KLU14387.1 KLU14387.1 rph rph ihfA ihfA dgt dgt
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLU16849.1Adenine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
KLU17374.1Adenylosuccinate synthetase; Catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (432 aa)
cyaAAdenylate cyclase; Catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; Derived by automated computational analysis using gene prediction method: Protein Homology. (872 aa)
KLU17426.1Guanosine polyphosphate pyrophosphohydrolase; Catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; Derived by automated computational analysis using gene prediction method: Protein Homology. (502 aa)
nudEAdenosine nucleotide hydrolase; ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
KLU17312.1(p)ppGpp synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (704 aa)
KLU17314.1Guanylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (207 aa)
KLU17105.1Ribonucleotide-diphosphate reductase subunit alpha; Catalyzes the rate-limiting step in dNTP synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (762 aa)
KLU17106.1Ribonucleotide-diphosphate reductase subunit beta; B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; Derived by automated computational analysis using gene prediction method: Protein Homology. (373 aa)
apaHDiadenosine tetraphosphatase; Hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
KLU17049.1Diguanylate phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
nudFADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
rihBRibonucleoside hydrolase; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
KLU16950.1Phosphopentomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
deoDPurine nucleoside phosphorylase; Catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
KLU16974.1Phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
KLU16994.1Purine NTP phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (175 aa)
ushA5'-nucleotidase; Catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; Derived by automated computational analysis using gene prediction method: Protein Homology. (555 aa)
KLU16918.1Guanosine kinase; Catalyzes the formation of inosine/guanosine monophosphate from inosine or guanosine and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
adkAdenylate kinase; Essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
KLU16867.1Transcriptional regulator HU subunit alpha; Histone-like DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (96 aa)
KLU16872.1Positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; Derived by automated computational analysis using gene prediction method: Protein Homology. (107 aa)
KLU16896.1NrdR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
cpdBPeriplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (651 aa)
KLU16813.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (526 aa)
truAtRNA pseudouridine synthase A; Mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; Derived by automated computational analysis using gene prediction method: Protein Homology. (279 aa)
KLU16758.1Amidophosphoribosyltransferase; Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (505 aa)
KLU16717.1Ribose-phosphate pyrophosphokinase; Catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. (312 aa)
ychFGTP-binding protein; EngD; translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
KLU16547.1Purine nucleoside phosphoramidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (116 aa)
KLU16574.1Dihydroorotate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (487 aa)
KLU16575.1Exopolyphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (510 aa)
purNPhosphoribosylglycinamide formyltransferase; Glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
KLU16579.1Phosphoribosylaminoimidazole synthetase; Catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
ihfBThis protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; Derived by automated computational analysis using gene prediction method: Protein Homology. (96 aa)
relA(p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; Derived by automated computational analysis using gene prediction method: Protein Homology. (744 aa)
mazGNucleoside triphosphate hydrolase; Functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa)
guaAGMP synthase; Contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (525 aa)
KLU16327.1Inosine-5-monophosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (488 aa)
KLU16337.1Phosphoribosylaminoimidazole-succinocarboxamide synthase; Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa)
KLU16344.1Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; Derived by automated computational analysis using gene prediction method: Protein Homology. (456 aa)
KLU16037.1Nucleoside diphosphate kinase; Catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
KLU16083.1Phosphoribosylformylglycinamidine synthase; Catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (1295 aa)
KLU16084.1tRNA adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
tilStRNA(Ile)-lysidine ligase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
KLU15674.1Sulfate adenylyltransferase subunit 2; With CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
cysNSulfate adenylyltransferase subunit 1; May be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
KLU15676.1Adenylylsulfate kinase; Converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
surEStationary phase survival protein SurE; Broad specificity 5'(3')-nucleotidase and polyphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
KLU15694.1Catalyzes the formation of inosine monophosphate from hypoxanthine and 5-phospho-alpha-D-ribose 1-diphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa)
KLU15615.1Ribonucleotide-diphosphate reductase subunit beta; B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
KLU15616.1Ribonucleotide-diphosphate reductase subunit alpha; Catalyzes the rate-limiting step in dNTP synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (763 aa)
KLU15391.1tRNA 2-thiocytidine biosynthesis protein TtcA; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
KLU15289.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
KLU15241.1YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; Derived by automated computational analysis using gene prediction method: Protein Homology. (369 aa)
KLU15246.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
KLU15207.1Phosphoglucomutase; Catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (546 aa)
KLU15104.1Xanthine-guanine phosphoribosyltransferase; Catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; Derived by automated computational analysis using gene prediction method: Protein Homology. (153 aa)
KLU14994.1Phosphoribosylaminoimidazole carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the formation of 4-carboxy-5-aminoimidazole ribonucleotide from N5-carboxyaminoimidazole ribonucleotide; Derived by automated computational analysis using gene prediction method: Protein Homology. (174 aa)
KLU14842.1Magnesium/cobalt efflux protein CorC; Involved in the transport of magnesium and cobalt ions; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
KLU14791.1Nucleoside-triphosphate diphosphatase; HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
KLU14792.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa)
KLU14640.1Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (529 aa)
KLU14571.1Phosphoribosylamine--glycine ligase; Catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
KLU14572.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (90 aa)
KLU14454.1Ribonucleoside-triphosphate reductase; Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; Derived by automated computational analysis using gene prediction method: Protein Homology. (637 aa)
KLU14365.1LOG family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
KLU14387.1Adenine/guanine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (394 aa)
rphRNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
ihfAThis protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; Derived by automated computational analysis using gene prediction method: Protein Homology. (98 aa)
dgtDeoxyguanosinetriphosphate triphosphohydrolase; Forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (511 aa)
Your Current Organism:
Xenorhabdus griffiniae
NCBI taxonomy Id: 351672
Other names: CIP 109073, DSM 17911, X. griffiniae, Xenorhabdus griffiniae Tailliez et al. 2006, Xenorhabdus sp. ID10, strain ID10
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