STRINGSTRING
ndk ndk AOM39433.1 AOM39433.1 upp upp add add tdk tdk AOM40294.1 AOM40294.1 tmk tmk AOM40597.1 AOM40597.1 AOM40598.1 AOM40598.1 AOM40599.1 AOM40599.1 dcd dcd udk udk cdd cdd adk adk apt apt AOM41195.1 AOM41195.1 AOM42876.1 AOM42876.1 deoD deoD rihB rihB AOM41464.1 AOM41464.1 cpdA cpdA AOM42895.1 AOM42895.1 AOM42896.1 AOM42896.1 AOM42902.1 AOM42902.1 dut dut AOM42025.1 AOM42025.1 cpdA-2 cpdA-2 AOM42316.1 AOM42316.1 AOM42464.1 AOM42464.1 surE surE pcm pcm AOM42506.1 AOM42506.1 rpoS rpoS dgt dgt rumA rumA AOM42553.1 AOM42553.1 AOM42554.1 AOM42554.1 pyrG pyrG AOM42973.1 AOM42973.1 ushA ushA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (142 aa)
AOM39433.15'-deoxynucleotidase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (193 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa)
addAdenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (333 aa)
tdkThymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
AOM40294.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (79 aa)
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (211 aa)
AOM40597.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (88 aa)
AOM40598.1Ribonucleotide-diphosphate reductase subunit beta; B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
AOM40599.1Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (763 aa)
dcddCTP deaminase; Catalyzes the deamination of dCTP to dUTP. (193 aa)
udkUridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (294 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa)
AOM41195.1Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (545 aa)
AOM42876.12',3'-cyclic-nucleotide 2'-phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (639 aa)
deoDPurine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
rihBRibonucleoside hydrolase; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IUNH family. (316 aa)
AOM41464.1Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa)
cpdAHypothetical protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (247 aa)
AOM42895.1Anaerobic ribonucleoside-triphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (631 aa)
AOM42896.1Anaerobic ribonucleotide reductase-activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (154 aa)
AOM42902.1Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the adenylyl cyclase class-1 family. (840 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa)
AOM42025.1Transcriptional regulator Crp; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
cpdA-23',5'-cyclic-AMP phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (279 aa)
AOM42316.1LOG family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
AOM42464.1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (251 aa)
surE5'/3'-nucleotidase SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (254 aa)
pcmprotein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (208 aa)
AOM42506.1Peptidase M23; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
rpoSRNA polymerase sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (330 aa)
dgtdGTPase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily. (511 aa)
rumA23S rRNA (uracil(1939)-C(5))-methyltransferase; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (445 aa)
AOM42553.1GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (745 aa)
AOM42554.1Nucleoside triphosphate pyrophosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
AOM42973.1Catalyzes the formation of inosine/guanosine monophosphate from inosine or guanosine and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
ushABifunctional UDP-sugar hydrolase/5'-nucleotidase; Catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (552 aa)
Your Current Organism:
Xenorhabdus hominickii
NCBI taxonomy Id: 351679
Other names: CIP 109072, DSM 17903, X. hominickii, Xenorhabdus hominickii Taillez et al. 2006, Xenorhabdus sp. KE01, Xenorhabdus sp. KR01, Xenorhabdus sp. KR05, strain KE01
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