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A9255_01080 A9255_01080 AOM39331.1 AOM39331.1 AOM39332.1 AOM39332.1 AOM39617.1 AOM39617.1 prs prs cutC cutC AOM39889.1 AOM39889.1 zwf zwf AOM40077.1 AOM40077.1 AOM40082.1 AOM40082.1 AOM40232.1 AOM40232.1 AOM40233.1 AOM40233.1 purR purR AOM40305.1 AOM40305.1 AOM40364.1 AOM40364.1 AOM40365.1 AOM40365.1 AOM40366.1 AOM40366.1 AOM40556.1 AOM40556.1 serC serC AOM40730.1 AOM40730.1 pgl pgl gpmA gpmA AOM40838.1 AOM40838.1 AOM40864.1 AOM40864.1 nagB nagB nagA nagA AOM41054.1 AOM41054.1 rpiA rpiA AOM41094.1 AOM41094.1 AOM41198.1 AOM41198.1 gpmB gpmB tal tal AOM41229.1 AOM41229.1 AOM41230.1 AOM41230.1 deoB deoB deoA deoA deoC deoC AOM41319.1 AOM41319.1 AOM41411.1 AOM41411.1 gntK gntK AOM41413.1 AOM41413.1 AOM41414.1 AOM41414.1 AOM41415.1 AOM41415.1 AOM42884.1 AOM42884.1 AOM41416.1 AOM41416.1 AOM41417.1 AOM41417.1 glmM glmM fbp fbp AOM41593.1 AOM41593.1 AOM41594.1 AOM41594.1 ppc ppc tpiA tpiA pfkA pfkA glmS glmS glmU glmU rbsK rbsK trpS trpS AOM41836.1 AOM41836.1 AOM41837.1 AOM41837.1 AOM41847.1 AOM41847.1 pckA pckA AOM41868.1 AOM41868.1 AOM41869.1 AOM41869.1 AOM42029.1 AOM42029.1 murQ murQ AOM42061.1 AOM42061.1 AOM42106.1 AOM42106.1 AOM42107.1 AOM42107.1 AOM42138.1 AOM42138.1 AOM42267.1 AOM42267.1 pgi pgi glk glk eno eno AOM42714.1 AOM42714.1 pgk pgk AOM42717.1 AOM42717.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A9255_01080Acetyltransferase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (169 aa)
AOM39331.1Phosphoenolpyruvate--protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (575 aa)
AOM39332.1PTS sugar transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (85 aa)
AOM39617.1Fructose-bisphosphate aldolase; Catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (349 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (336 aa)
cutCCopper homeostasis protein CutC; Participates in the control of copper homeostasis. Belongs to the CutC family. (248 aa)
AOM39889.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (480 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
AOM40077.1Transcriptional regulator; Mlc, controls the expression of genes involved in the phosphotransferase and phosphoenolpyruvate systems, regulates genes involved in the uptake of sugars; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
AOM40082.1Mannose-6-phosphate isomerase; Catalyzes the formation of of fructose 6-phosphate from mannose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
AOM40232.1Type I glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
AOM40233.1D-hexose-6-phosphate mutarotase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glucose-6-phosphate 1-epimerase family. (293 aa)
purRTranscriptional repressor PurR; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. (341 aa)
AOM40305.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (469 aa)
AOM40364.1PTS mannose transporter subunit IIAB; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
AOM40365.1PTS mannose/fructose/sorbose transporter subunit IIC; Catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; the IIC domain forms the PTS system translocation channel and contains the specific substrate-binding site; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
AOM40366.1PTS mannose transporter subunit IID; Hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
AOM40556.11-phosphofructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. (312 aa)
serCPhosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
AOM40730.1Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
pgl6-phosphogluconolactonase; Catalyzes the hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. (328 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa)
AOM40838.1Phosphoglucomutase, alpha-D-glucose phosphate-specific; Catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (546 aa)
AOM40864.1PTS N-acetyl-D-glucosamine transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (504 aa)
nagBGlucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (271 aa)
nagAN-acetylglucosamine-6-phosphate deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
AOM41054.1D-3-phosphoglycerate dehydrogenase; Catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (413 aa)
rpiARibose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (219 aa)
AOM41094.1DNA-binding transcriptional regulator FruR; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
AOM41198.1Fructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
gpmBPhosphoglycerate mutase; Catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (317 aa)
AOM41229.16-phospho-beta-glucosidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycosyl hydrolase 1 family. (467 aa)
AOM41230.1PTS beta-glucoside transporter subunit IIABC; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (458 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (407 aa)
deoAThymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (455 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (259 aa)
AOM41319.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa)
AOM41411.1Gluconate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
gntKGluconate kinase; Thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
AOM41413.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
AOM41414.1LacI family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
AOM41415.16-phospho-beta-glucosidase; Catalyzes the fromation of N-acetyl-D-glucosamine and N-acetyl-D-glucosamine-6-phosphate from diacetylchitobiose-6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
AOM42884.1Molecular chaperone TorD; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa)
AOM41416.1PTS cellobiose transporter subunit IIC; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (432 aa)
AOM41417.1PTS sugar transporter subunit IIB; Derived by automated computational analysis using gene prediction method: Protein Homology. (101 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (445 aa)
fbpFructose-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FBPase class 1 family. (334 aa)
AOM41593.1LacI family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
AOM41594.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (878 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa)
glmSGlutamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa)
glmUUDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (461 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (309 aa)
trpStryptophan--tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (345 aa)
AOM41836.1Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (240 aa)
AOM41837.1Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa)
AOM41847.1ADP compounds hydrolase NudE; Derived by automated computational analysis using gene prediction method: Protein Homology. (186 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (539 aa)
AOM41868.1Alpha,alpha-phosphotrehalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (553 aa)
AOM41869.1PTS trehalose transporter subunit IIBC; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
AOM42029.1PTS N-acetylmuramic acid transporter subunits IIBC; Derived by automated computational analysis using gene prediction method: Protein Homology. (488 aa)
murQN-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. (302 aa)
AOM42061.1Zinc-binding dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
AOM42106.1Gluconate:proton symporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
AOM42107.1Glycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (377 aa)
AOM42138.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (317 aa)
AOM42267.1ADP-ribose diphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (548 aa)
glkGlucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial glucokinase family. (322 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (433 aa)
AOM42714.1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (664 aa)
pgkPhosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (388 aa)
AOM42717.1Class II fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (358 aa)
Your Current Organism:
Xenorhabdus hominickii
NCBI taxonomy Id: 351679
Other names: CIP 109072, DSM 17903, X. hominickii, Xenorhabdus hominickii Taillez et al. 2006, Xenorhabdus sp. KE01, Xenorhabdus sp. KR01, Xenorhabdus sp. KR05, strain KE01
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