STRINGSTRING
pagP pagP hldD hldD AOM41733.1 AOM41733.1 AOM41731.1 AOM41731.1 AOM41728.1 AOM41728.1 tpiA tpiA wecA wecA wzzE wzzE wecB wecB wecC wecC AOM41619.1 AOM41619.1 wecD wecD wecE wecE wzxE wzxE wecF wecF wzyE wzyE arnE arnE arnF arnF AOM40311.1 AOM40311.1 AOM40143.1 AOM40143.1 AOM40142.1 AOM40142.1 lpxM lpxM kdsA kdsA AOM39777.1 AOM39777.1 AOM41744.1 AOM41744.1 lpxL lpxL AOM39352.1 AOM39352.1 arnT arnT arnD arnD arnA arnA arnC arnC arnB arnB AOM40363.1 AOM40363.1 lpxT lpxT spr spr kdsB kdsB lpxK lpxK gpmA gpmA gmhA gmhA lpxC lpxC AOM41208.1 AOM41208.1 AOM41408.1 AOM41408.1 fbp fbp wecG wecG lpxD lpxD fabZ fabZ lpxA lpxA lpxB lpxB pgi pgi AOM42512.1 AOM42512.1 AOM42559.1 AOM42559.1 lpxH lpxH AOM42287.1 AOM42287.1 hldE hldE AOM42153.1 AOM42153.1 AOM42152.1 AOM42152.1 AOM41924.1 AOM41924.1 pckA pckA glmU glmU AOM41774.1 AOM41774.1 AOM41758.1 AOM41758.1 AOM41757.1 AOM41757.1 AOM42912.1 AOM42912.1 AOM41756.1 AOM41756.1 AOM41755.1 AOM41755.1 AOM41752.1 AOM41752.1 AOM41751.1 AOM41751.1 AOM41750.1 AOM41750.1 AOM41749.1 AOM41749.1 AOM41748.1 AOM41748.1 AOM42911.1 AOM42911.1 AOM41746.1 AOM41746.1 AOM41745.1 AOM41745.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pagPPhospholipid:lipid A palmitoyltransferase; Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. (175 aa)
hldDADP-glyceromanno-heptose 6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (312 aa)
AOM41733.1UDP-N-acetylglucosamine 4-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
AOM41731.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (358 aa)
AOM41728.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (421 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
wecAUndecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (362 aa)
wzzEPolysaccharide chain length modulation protein; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family. (353 aa)
wecBUDP-N-acetylglucosamine 2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. (376 aa)
wecCUDP-N-acetyl-D-mannosamine dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa)
AOM41619.1Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (293 aa)
wecDTDP-D-fucosamine acetyltransferase; Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino- 4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA). Belongs to the WecD family. (237 aa)
wecEdTDP-4-amino-4,6-dideoxygalactose transaminase; Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate; Belongs to the DegT/DnrJ/EryC1 family. (376 aa)
wzxEO-antigen translocase; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family. (416 aa)
wecF4-alpha-L-fucosyltransferase; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family. (364 aa)
wzyEEnterobacterial common antigen polymerase; Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units; Belongs to the WzyE family. (480 aa)
arnE4-amino-4-deoxy-L-arabinose-phospho-UDP flippase; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. (115 aa)
arnF4-amino-4-deoxy-L-arabinose-phospho-UDP flippase; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. (128 aa)
AOM40311.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa)
AOM40143.1UDP-glucose 6-dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (447 aa)
AOM40142.1Capsular biosynthesis protein CpsI; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa)
lpxMLipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (322 aa)
kdsA3-deoxy-8-phosphooctulonate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the KdsA family. (284 aa)
AOM39777.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
AOM41744.1ADP-heptose--LPS heptosyltransferase; Catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
lpxLLipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (313 aa)
AOM39352.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (261 aa)
arnT4-amino-4-deoxy-L-arabinose lipid A transferase; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family. (553 aa)
arnD4-deoxy-4-formamido-L-arabinose- phosphoundecaprenol deformylase; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. (297 aa)
arnABifunctional UDP-glucuronic acid oxidase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the N-terminal section; belongs to the Fmt family. UDP- L-Ara4N formyltransferase subfamily. (660 aa)
arnCUndecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (325 aa)
arnBUDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (381 aa)
AOM40363.1L-serine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa)
lpxTHypothetical protein; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (234 aa)
sprLipoprotein Spr; Mutational suppressor of prc thermosensitivity; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (249 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (330 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa)
gmhAPhosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (193 aa)
lpxCUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (305 aa)
AOM41208.12,5-didehydrogluconate reductase A; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
AOM41408.1Alginate O-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the membrane-bound acyltransferase family. (473 aa)
fbpFructose-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FBPase class 1 family. (334 aa)
wecGLipopolysaccharide N-acetylmannosaminouronosyltransferase; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis. (245 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (342 aa)
fabZ3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (150 aa)
lpxAacyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (265 aa)
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (394 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (548 aa)
AOM42512.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (522 aa)
AOM42559.1LPS O-antigen length regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
lpxHUDP-2,3-diacylglucosamine diphosphatase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (240 aa)
AOM42287.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (567 aa)
hldEBifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (474 aa)
AOM42153.1D-arabinose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
AOM42152.13-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (187 aa)
AOM41924.1Glycosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (489 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (539 aa)
glmUUDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (461 aa)
AOM41774.1Phosphoethanolamine transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (549 aa)
AOM41758.1Glycosyl transferase family 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (372 aa)
AOM41757.1WalO protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
AOM42912.1WalN protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
AOM41756.1WalM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
AOM41755.1Ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (408 aa)
AOM41752.1Lipopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
AOM41751.13-deoxy-D-manno-octulosonic acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (425 aa)
AOM41750.1Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
AOM41749.1Glycosyl transferase family 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
AOM41748.1Putative lipopolysaccharide heptosyltransferase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa)
AOM42911.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
AOM41746.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
AOM41745.1Lipopolysaccharide heptosyltransferase 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
Your Current Organism:
Xenorhabdus hominickii
NCBI taxonomy Id: 351679
Other names: CIP 109072, DSM 17903, X. hominickii, Xenorhabdus hominickii Taillez et al. 2006, Xenorhabdus sp. KE01, Xenorhabdus sp. KR01, Xenorhabdus sp. KR05, strain KE01
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.