STRINGSTRING
AOM41198.1 AOM41198.1 AOM40836.1 AOM40836.1 AOM40749.1 AOM40749.1 AOM40730.1 AOM40730.1 kdsB kdsB spr spr arnC arnC lpxT lpxT arnA arnA arnD arnD arnT arnT arnE arnE arnF arnF arnB arnB AOM40142.1 AOM40142.1 AOM40440.1 AOM40440.1 AOM40556.1 AOM40556.1 wecF wecF wzyE wzyE AOM41619.1 AOM41619.1 wecD wecD wecE wecE wecG wecG wzxE wzxE pfkA pfkA glpK glpK wecA wecA wzzE wzzE wecB wecB wecC wecC lapA lapA lapB lapB lpxM lpxM kdsA kdsA AOM39777.1 AOM39777.1 AOM39587.1 AOM39587.1 lpxL lpxL AOM39352.1 AOM39352.1 AOM39297.1 AOM39297.1 cysQ cysQ AOM41408.1 AOM41408.1 gmhA gmhA AOM42740.1 AOM42740.1 AOM42739.1 AOM42739.1 AOM42737.1 AOM42737.1 AOM42735.1 AOM42735.1 AOM42734.1 AOM42734.1 AOM42559.1 AOM42559.1 AOM42512.1 AOM42512.1 glk glk aceK aceK AOM42957.1 AOM42957.1 AOM42287.1 AOM42287.1 hldE hldE AOM42153.1 AOM42153.1 AOM42152.1 AOM42152.1 gldA gldA slyX slyX AOM41924.1 AOM41924.1 glpE glpE AOM41868.1 AOM41868.1 AOM41774.1 AOM41774.1 AOM41758.1 AOM41758.1 AOM41757.1 AOM41757.1 AOM42912.1 AOM42912.1 AOM41756.1 AOM41756.1 AOM41755.1 AOM41755.1 AOM41752.1 AOM41752.1 AOM41751.1 AOM41751.1 AOM41750.1 AOM41750.1 AOM41749.1 AOM41749.1 AOM41748.1 AOM41748.1 AOM42911.1 AOM42911.1 AOM41746.1 AOM41746.1 AOM41745.1 AOM41745.1 AOM41744.1 AOM41744.1 hldD hldD AOM41733.1 AOM41733.1 AOM41731.1 AOM41731.1 AOM41728.1 AOM41728.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AOM41198.1Fructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
AOM40836.1Pullulanase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycosyl hydrolase 13 family. (943 aa)
AOM40749.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
AOM40730.1Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (249 aa)
sprLipoprotein Spr; Mutational suppressor of prc thermosensitivity; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa)
arnCUndecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (325 aa)
lpxTHypothetical protein; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (234 aa)
arnABifunctional UDP-glucuronic acid oxidase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the N-terminal section; belongs to the Fmt family. UDP- L-Ara4N formyltransferase subfamily. (660 aa)
arnD4-deoxy-4-formamido-L-arabinose- phosphoundecaprenol deformylase; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. (297 aa)
arnT4-amino-4-deoxy-L-arabinose lipid A transferase; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family. (553 aa)
arnE4-amino-4-deoxy-L-arabinose-phospho-UDP flippase; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. (115 aa)
arnF4-amino-4-deoxy-L-arabinose-phospho-UDP flippase; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. (128 aa)
arnBUDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (381 aa)
AOM40142.1Capsular biosynthesis protein CpsI; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa)
AOM40440.1NADP-dependent isocitrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa)
AOM40556.11-phosphofructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. (312 aa)
wecF4-alpha-L-fucosyltransferase; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family. (364 aa)
wzyEEnterobacterial common antigen polymerase; Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units; Belongs to the WzyE family. (480 aa)
AOM41619.1Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (293 aa)
wecDTDP-D-fucosamine acetyltransferase; Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino- 4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA). Belongs to the WecD family. (237 aa)
wecEdTDP-4-amino-4,6-dideoxygalactose transaminase; Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate; Belongs to the DegT/DnrJ/EryC1 family. (376 aa)
wecGLipopolysaccharide N-acetylmannosaminouronosyltransferase; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis. (245 aa)
wzxEO-antigen translocase; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family. (416 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (507 aa)
wecAUndecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (362 aa)
wzzEPolysaccharide chain length modulation protein; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family. (353 aa)
wecBUDP-N-acetylglucosamine 2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. (376 aa)
wecCUDP-N-acetyl-D-mannosamine dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa)
lapAHypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. (104 aa)
lapBLipopolysaccharide assembly protein LapB; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. (389 aa)
lpxMLipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (322 aa)
kdsA3-deoxy-8-phosphooctulonate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the KdsA family. (284 aa)
AOM39777.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
AOM39587.1Sugar kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (531 aa)
lpxLLipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (313 aa)
AOM39352.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (261 aa)
AOM39297.1Inositol monophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the inositol monophosphatase superfamily. (267 aa)
cysQ3'(2'),5'-bisphosphate nucleotidase CysQ; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (247 aa)
AOM41408.1Alginate O-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the membrane-bound acyltransferase family. (473 aa)
gmhAPhosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (193 aa)
AOM42740.15-deoxy-glucuronate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
AOM42739.1Myo-inosose-2 dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
AOM42737.1Myo-inositol 2-dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
AOM42735.1Inositol 2-dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
AOM42734.13D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing); Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (649 aa)
AOM42559.1LPS O-antigen length regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
AOM42512.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (522 aa)
glkGlucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial glucokinase family. (322 aa)
aceKBifunctional isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (591 aa)
AOM42957.1Malate synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology. (532 aa)
AOM42287.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (567 aa)
hldEBifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (474 aa)
AOM42153.1D-arabinose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
AOM42152.13-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (187 aa)
gldAGlycerol dehydrogenase; Forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; Derived by automated computational analysis using gene prediction method: Protein Homology. (366 aa)
slyXLysis protein; Required for phi X174 lysis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SlyX family. (72 aa)
AOM41924.1Glycosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (489 aa)
glpEThiosulfate sulfurtransferase; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. (107 aa)
AOM41868.1Alpha,alpha-phosphotrehalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (553 aa)
AOM41774.1Phosphoethanolamine transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (549 aa)
AOM41758.1Glycosyl transferase family 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (372 aa)
AOM41757.1WalO protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
AOM42912.1WalN protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
AOM41756.1WalM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
AOM41755.1Ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (408 aa)
AOM41752.1Lipopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
AOM41751.13-deoxy-D-manno-octulosonic acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (425 aa)
AOM41750.1Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
AOM41749.1Glycosyl transferase family 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
AOM41748.1Putative lipopolysaccharide heptosyltransferase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa)
AOM42911.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
AOM41746.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
AOM41745.1Lipopolysaccharide heptosyltransferase 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
AOM41744.1ADP-heptose--LPS heptosyltransferase; Catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
hldDADP-glyceromanno-heptose 6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (312 aa)
AOM41733.1UDP-N-acetylglucosamine 4-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
AOM41731.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (358 aa)
AOM41728.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (421 aa)
Your Current Organism:
Xenorhabdus hominickii
NCBI taxonomy Id: 351679
Other names: CIP 109072, DSM 17903, X. hominickii, Xenorhabdus hominickii Taillez et al. 2006, Xenorhabdus sp. KE01, Xenorhabdus sp. KR01, Xenorhabdus sp. KR05, strain KE01
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