(33 nodes) Spliceosomal snRNP complex network (Cryptosporidium parvum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cgd6_2830	Splicing factor 3a 66kD N-terminus C2H2 domain. (216 aa)
	cgd6_3490	RNA-binding protein, putative. (153 aa)
	cgd6_4750	Splicing factor 3B subunit1-like HEAT repeat containing protein. (1031 aa)
	cgd8_3690	Mitosis protein DIM1. (142 aa)
	cgd8_4240	Possible spliceosome factor. (1317 aa)
	cgd8_5130	RRM domain-containing protein. (274 aa)
	cgd4_890	Uncharacterized protein. (85 aa)
	cgd5_4060	Matrin-type domain-containing protein. (198 aa)
	cgd4_150	Pre-mRNA splicing protein Prp31p--like. (463 aa)
	cgd4_1570	Uncharacterized protein. (407 aa)
	cgd5_1740	Conserved protein, possible U4/U6 associated RNA splicing factor. (452 aa)
	cgd5_920	Pre-mRNA splicing factor Pro1/Prp6. HAT repeat protein. (923 aa)
	cgd1_2250	Small nuclear ribonucleoprotein Sm D3. (143 aa)
	cgd6_2550	Uncharacterized protein. (380 aa)
	cgd7_5490	PRP18 (SFM+PRP18 domains). (337 aa)
	LSM8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (99 aa)
	LSM5	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (121 aa)
	cgd7_3520	Sm domain-containing protein. (73 aa)
	cgd7_2160	Pre-mRNA splicing factor SF3a. 2xSWAP domain protein. (462 aa)
	cgd3_1060	U1 like C2H2 zinc finger. (198 aa)
	cgd3_2890	Prp8. JAB/PAD domain. (2379 aa)
	cgd3_3880	Snu114p GTpase, U5 snRNP-specific protein, 116 kDa. (1035 aa)
	cgd2_3510	Cus1p U2 snRNP protein. (602 aa)
	cgd4_1660	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (92 aa)
	cgd7_2040	Small nuclear ribonucleo protein. (93 aa)
	cgd7_1070	SnRNP core protein. (107 aa)
	LSM3	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
	cgd4_2710	Uncharacterized protein. (77 aa)
	cgd4_3190	Small nuclear ribonucleoprotein Sm D2. (106 aa)
	cgd3_2310	RRM domain-containing protein. (86 aa)
	cgd6_2400	Uncharacterized protein. (100 aa)
	cgd7_3970	Small nuclear ribonucleoprotein, putative. (62 aa)
	cgd1_2690	Sm domain-containing protein. (67 aa)

Your Current Organism:

Cryptosporidium parvum

NCBI taxonomy Id: 353152
Other names: C. parvum Iowa II, Cryptosporidium parvum Iowa II, Cryptosporidium parvum strain Iowa type II

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LSM3	LSM5	Q5CYX1	Q5CXX3	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	0.999
LSM3	LSM8	Q5CYX1	Q5CXQ2	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.999
LSM3	cgd1_2250	Q5CYX1	Q5CSL0	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Small nuclear ribonucleoprotein Sm D3.	0.994
LSM3	cgd1_2690	Q5CYX1	A3FQF0	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Sm domain-containing protein.	0.988
LSM3	cgd2_3510	Q5CYX1	Q5CTD1	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Cus1p U2 snRNP protein.	0.938
LSM3	cgd3_1060	Q5CYX1	Q5CUY0	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	U1 like C2H2 zinc finger.	0.971
LSM3	cgd3_2310	Q5CYX1	A3FQ28	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	RRM domain-containing protein.	0.726
LSM3	cgd3_2890	Q5CYX1	Q5CUG7	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Prp8. JAB/PAD domain.	0.994
LSM3	cgd3_3880	Q5CYX1	Q5CU80	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Snu114p GTpase, U5 snRNP-specific protein, 116 kDa.	0.994
LSM3	cgd4_150	Q5CYX1	Q5CQM4	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Pre-mRNA splicing protein Prp31p--like.	0.996
LSM3	cgd4_1570	Q5CYX1	Q5CR99	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.994
LSM3	cgd4_1660	Q5CYX1	A3FQK4	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.997
LSM3	cgd4_2710	Q5CYX1	A3FQL4	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.999
LSM3	cgd4_3190	Q5CYX1	A3FQL7	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Small nuclear ribonucleoprotein Sm D2.	0.997
LSM3	cgd4_890	Q5CYX1	A3FQN7	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.918
LSM3	cgd5_1740	Q5CYX1	Q5CRR8	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Conserved protein, possible U4/U6 associated RNA splicing factor.	0.996
LSM3	cgd5_4060	Q5CYX1	Q5CQ56	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Matrin-type domain-containing protein.	0.450
LSM3	cgd5_920	Q5CYX1	Q5CRZ2	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Pre-mRNA splicing factor Pro1/Prp6. HAT repeat protein.	0.978
LSM3	cgd6_2400	Q5CYX1	A3FPU6	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.938
LSM3	cgd6_2830	Q5CYX1	Q5CX23	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Splicing factor 3a 66kD N-terminus C2H2 domain.	0.904