(30 nodes) Winged helix DNA-binding domain superfamily network (Cryptosporidium parvum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cgd7_290	RAD21-N-terminal like protein. (646 aa)
	cgd7_440	RIO-like kinase domain N-terminal region conserved. (488 aa)
	cgd7_3650	DP1 DNA binding protein. (279 aa)
	cgd6_1430	Transcription factor E2F wHTH only. (666 aa)
	cgd6_3590	26S proteasome regulatory subunit Rpn6-like PINT domain containing protein. (422 aa)
	cgd6_4040	Cullin domain containing protein; Belongs to the cullin family. (1204 aa)
	cgd6_4580	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (319 aa)
	cgd8_1020	Rad21_Rec8 domain-containing protein. (458 aa)
	cgd8_1850	E2F like domain containing transcription factor with the wHTH fold. (293 aa)
	cgd2_2480	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (472 aa)
	cgd2_2770	Activating signal cointegrator complex subunit 3. (2184 aa)
	cgd1_850	40S ribosomal protein S19. (154 aa)
	cgd1_1530	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein. (559 aa)
	cgd1_1560	Domain KOG2577, transcription factor E2F/dimerization partner (TDP). (395 aa)
	cgd1_1740	Hypothetical coiled coil protein. (261 aa)
	cgd5_2960	U5snrp Brr2 SFII RNA helicase (sec63 and the second part of the RNA). (1204 aa)
	cgd4_2150	CDT1 domain-containing protein. (727 aa)
	cgd4_3150	Cullin-like protein of probable plant origin; Belongs to the cullin family. (826 aa)
	cgd4_3770	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (1040 aa)
	cgd4_3810	Putative transcription factor IIE alpha subunit. (504 aa)
	cgd1_2310	Unnamed protein product. (163 aa)
	cgd8_2420	Transcription initiation factor IIF/ Rap30 like winged HTH. (186 aa)
	cgd8_3220	HTH La-type RNA-binding domain-containing protein. (385 aa)
	cgd8_4060	26S proteasomal subunit S3 PINT domain containing protein. (551 aa)
	cgd3_2390	Proliferation-associated protein 2G4 metalloprotease, creatinase/aminopeptidase fold. (381 aa)
	cgd3_2790	Cullin domain containing protein; Belongs to the cullin family. (851 aa)
	cgd3_4020	eIF-3 p25/subunit 11. (262 aa)
	cgd2_1020	Proteasome regulatory subunit Rpn9, PINT domain. (430 aa)
	cgd2_1500	Possible translation initiation factor with possible PINT domain; Belongs to the eIF-3 subunit E family. (540 aa)
	cgd2_2210	Proteasome regulatory subunit Rpn7/26S proteasome subunit 6, PINT domain containing protein. (403 aa)

Your Current Organism:

Cryptosporidium parvum

NCBI taxonomy Id: 353152
Other names: C. parvum Iowa II, Cryptosporidium parvum Iowa II, Cryptosporidium parvum strain Iowa type II

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cgd1_1530	cgd2_1020	Q5CSS4	Q5CTY7	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Proteasome regulatory subunit Rpn9, PINT domain.	0.999
cgd1_1530	cgd2_1500	Q5CSS4	Q5CTU7	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Possible translation initiation factor with possible PINT domain; Belongs to the eIF-3 subunit E family.	0.857
cgd1_1530	cgd2_2210	Q5CSS4	Q5CTP3	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Proteasome regulatory subunit Rpn7/26S proteasome subunit 6, PINT domain containing protein.	0.999
cgd1_1530	cgd3_2790	Q5CSS4	Q5CUH7	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Cullin domain containing protein; Belongs to the cullin family.	0.700
cgd1_1530	cgd4_3150	Q5CSS4	Q5CQV3	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Cullin-like protein of probable plant origin; Belongs to the cullin family.	0.700
cgd1_1530	cgd4_3770	Q5CSS4	Q5CQQ0	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.476
cgd1_1530	cgd6_3590	Q5CSS4	Q5CWV3	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	26S proteasome regulatory subunit Rpn6-like PINT domain containing protein.	0.999
cgd1_1530	cgd8_4060	Q5CSS4	Q5CVH2	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	26S proteasomal subunit S3 PINT domain containing protein.	0.999
cgd1_1560	cgd3_2790	Q5CSS1	Q5CUH7	Domain KOG2577, transcription factor E2F/dimerization partner (TDP).	Cullin domain containing protein; Belongs to the cullin family.	0.513
cgd1_1560	cgd4_3150	Q5CSS1	Q5CQV3	Domain KOG2577, transcription factor E2F/dimerization partner (TDP).	Cullin-like protein of probable plant origin; Belongs to the cullin family.	0.513
cgd1_1560	cgd7_290	Q5CSS1	Q5CZ09	Domain KOG2577, transcription factor E2F/dimerization partner (TDP).	RAD21-N-terminal like protein.	0.426
cgd1_1560	cgd7_3650	Q5CSS1	Q5CY52	Domain KOG2577, transcription factor E2F/dimerization partner (TDP).	DP1 DNA binding protein.	0.870
cgd1_1560	cgd8_1850	Q5CSS1	Q5CW30	Domain KOG2577, transcription factor E2F/dimerization partner (TDP).	E2F like domain containing transcription factor with the wHTH fold.	0.870
cgd1_2310	cgd1_850	A3FQE3	Q5CSY3	Unnamed protein product.	40S ribosomal protein S19.	0.402
cgd1_2310	cgd2_1500	A3FQE3	Q5CTU7	Unnamed protein product.	Possible translation initiation factor with possible PINT domain; Belongs to the eIF-3 subunit E family.	0.555
cgd1_2310	cgd3_4020	A3FQE3	Q5CU68	Unnamed protein product.	eIF-3 p25/subunit 11.	0.426
cgd1_2310	cgd4_3770	A3FQE3	Q5CQQ0	Unnamed protein product.	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.506
cgd1_850	cgd1_2310	Q5CSY3	A3FQE3	40S ribosomal protein S19.	Unnamed protein product.	0.402
cgd1_850	cgd2_1500	Q5CSY3	Q5CTU7	40S ribosomal protein S19.	Possible translation initiation factor with possible PINT domain; Belongs to the eIF-3 subunit E family.	0.983
cgd1_850	cgd2_2480	Q5CSY3	Q5CTL9	40S ribosomal protein S19.	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	0.649