(42 nodes) Orc1 removal from chromatin network (Cryptosporidium parvum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cgd6_3270	26S proteasome-associated Mov34/MPN/PAD-1 family protein. (315 aa)
	cgd7_4550	Ubiquitin-like protein, putative. (78 aa)
	cgd6_920	26s protease regulatory subunit 8, putative; Belongs to the AAA ATPase family. (393 aa)
	cgd1_420	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (203 aa)
	cgd5_1820	Proteasome subunit alpha type. (255 aa)
	cgd4_4320	ORC/CDC6 like AAA+ ATpase. (868 aa)
	cgd4_3950	RPN2/26s proteasome regulatory subunit; Belongs to the proteasome subunit S1 family. (1075 aa)
	cgd8_630	26S proteasome regulatory complex, subunit PSMD5. (505 aa)
	cgd8_570	Proteasome regulatory subunit S2 (RPN1). (1045 aa)
	cgd5_4210	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (290 aa)
	cgd4_1170	26S proteasome regulatory subunit S4 like AAA ATpase; Belongs to the AAA ATPase family. (445 aa)
	cgd4_530	26S proteasome regulatory subunit 5a with a vWA domain and two ubiquitin interacting motifs (UIM). (383 aa)
	cgd4_450	Very large low complexity protein. (2423 aa)
	cgd4_430	ORC5 like AAA+ ATpase. (739 aa)
	cgd4_250	Proteasome subunit alpha type. (271 aa)
	cgd4_3080	Ribosomal protein S27a, ubiquitin plus zincribbon, UB13p. (159 aa)
	cgd4_2540	26S proteasome regulatory subunit 26b like AAA ATpase; Belongs to the AAA ATPase family. (401 aa)
	cgd4_1930	Putative origin recognition complex protein subunit 2, orc2. (355 aa)
	cgd5_3220	Proteasome subunit beta7 NTN hydrolase fold. (310 aa)
	cgd5_2550	Polyubiquitin with 3 Ub domains. (241 aa)
	cgd5_2360	P27 like 26S proteasomal subunit with a PDZ domain. (249 aa)
	cgd1_1530	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein. (559 aa)
	cgd2_3370	Proteasome regulatory subunit Rpn12 family. (282 aa)
	cgd2_2210	Proteasome regulatory subunit Rpn7/26S proteasome subunit 6, PINT domain containing protein. (403 aa)
	cgd2_2050	Proteasome subunit alpha type. (288 aa)
	cgd2_1550	Origin recognition complex 4 orc4p like AAA+ ATpase. (495 aa)
	cgd2_1440	Proteasome subunit alpha type. (256 aa)
	cgd2_1350	26S proteasome regulatory subunit, S6a like AAA ATpase; Belongs to the AAA ATPase family. (461 aa)
	cgd2_1020	Proteasome regulatory subunit Rpn9, PINT domain. (430 aa)
	cgd2_860	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (248 aa)
	cgd2_530	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (204 aa)
	cgd3_2530	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (279 aa)
	cgd3_2200	Proteasome subunit alpha type. (251 aa)
	cgd3_2170	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (252 aa)
	cgd8_3090	Proteasome activator p28/ Ki autoantigen. (234 aa)
	cgd8_840	26S proteasome regulatory subunit S10b like AAA+ ATpase; Belongs to the AAA ATPase family. (406 aa)
	cgd6_4350	26S proteasome regulatory subunit 7 (RPT1)-like; Belongs to the AAA ATPase family. (432 aa)
	cgd6_3590	26S proteasome regulatory subunit Rpn6-like PINT domain containing protein. (422 aa)
	cgd7_3660	Proteasome subunit alpha type. (283 aa)
	cgd7_2900	26S proteasome regulatory subunit, inactive JAB domain protein. (313 aa)
	cgd7_2310	ORC/CDC6 like AAA ATpase. (551 aa)
	cgd7_2280	60S ribosomal protein L40. (132 aa)

Your Current Organism:

Cryptosporidium parvum

NCBI taxonomy Id: 353152
Other names: C. parvum Iowa II, Cryptosporidium parvum Iowa II, Cryptosporidium parvum strain Iowa type II

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cgd1_1530	cgd1_420	Q5CSS4	A3FQB4	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.999
cgd1_1530	cgd2_1020	Q5CSS4	Q5CTY7	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Proteasome regulatory subunit Rpn9, PINT domain.	0.999
cgd1_1530	cgd2_1350	Q5CSS4	Q5CTW0	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	26S proteasome regulatory subunit, S6a like AAA ATpase; Belongs to the AAA ATPase family.	0.999
cgd1_1530	cgd2_1440	Q5CSS4	Q5CTV2	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Proteasome subunit alpha type.	0.997
cgd1_1530	cgd2_2050	Q5CSS4	Q5CTQ7	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Proteasome subunit alpha type.	0.998
cgd1_1530	cgd2_2210	Q5CSS4	Q5CTP3	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Proteasome regulatory subunit Rpn7/26S proteasome subunit 6, PINT domain containing protein.	0.999
cgd1_1530	cgd2_3370	Q5CSS4	Q5CTE2	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Proteasome regulatory subunit Rpn12 family.	0.999
cgd1_1530	cgd2_530	Q5CSS4	Q5CU29	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.998
cgd1_1530	cgd2_860	Q5CSS4	Q5CU00	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.997
cgd1_1530	cgd3_2170	Q5CSS4	Q5CUM9	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Proteasome endopeptidase complex; Belongs to the peptidase T1A family.	0.999
cgd1_1530	cgd3_2200	Q5CSS4	Q5CUM6	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Proteasome subunit alpha type.	0.998
cgd1_1530	cgd3_2530	Q5CSS4	Q5CUK0	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.999
cgd1_1530	cgd4_1170	Q5CSS4	Q5CQD4	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	26S proteasome regulatory subunit S4 like AAA ATpase; Belongs to the AAA ATPase family.	0.999
cgd1_1530	cgd4_250	Q5CSS4	Q5CQL5	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Proteasome subunit alpha type.	0.999
cgd1_1530	cgd4_2540	Q5CSS4	Q5CR10	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	26S proteasome regulatory subunit 26b like AAA ATpase; Belongs to the AAA ATPase family.	0.999
cgd1_1530	cgd4_3080	Q5CSS4	Q5CQW0	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Ribosomal protein S27a, ubiquitin plus zincribbon, UB13p.	0.962
cgd1_1530	cgd4_3950	Q5CSS4	Q5CPU8	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	RPN2/26s proteasome regulatory subunit; Belongs to the proteasome subunit S1 family.	0.999
cgd1_1530	cgd4_4320	Q5CSS4	Q5CPR7	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	ORC/CDC6 like AAA+ ATpase.	0.614
cgd1_1530	cgd4_450	Q5CSS4	Q5CQJ6	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	Very large low complexity protein.	0.863
cgd1_1530	cgd4_530	Q5CSS4	Q5CQJ0	Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein.	26S proteasome regulatory subunit 5a with a vWA domain and two ubiquitin interacting motifs (UIM).	0.999