STRINGSTRING
pfk pfk Q4CNY1_TRYCC Q4CNY1_TRYCC Q4CQ52_TRYCC Q4CQ52_TRYCC Q4CR01_TRYCC Q4CR01_TRYCC Q4CSB9_TRYCC Q4CSB9_TRYCC Q4CSC4_TRYCC Q4CSC4_TRYCC Q4CSE9_TRYCC Q4CSE9_TRYCC PURA2_TRYCC PURA2_TRYCC Q4CXU8_TRYCC Q4CXU8_TRYCC Q4CZ09_TRYCC Q4CZ09_TRYCC Q4D043_TRYCC Q4D043_TRYCC Q4D0A7_TRYCC Q4D0A7_TRYCC Q4D161_TRYCC Q4D161_TRYCC Q4D3A0_TRYCC Q4D3A0_TRYCC Q4D3Y2_TRYCC Q4D3Y2_TRYCC Q4D434_TRYCC Q4D434_TRYCC Q4D526_TRYCC Q4D526_TRYCC Q4D6K7_TRYCC Q4D6K7_TRYCC Q4D790_TRYCC Q4D790_TRYCC Q4D7R4_TRYCC Q4D7R4_TRYCC Q4D911_TRYCC Q4D911_TRYCC Q4D9Z4_TRYCC Q4D9Z4_TRYCC Q4DA33_TRYCC Q4DA33_TRYCC Q4DA83_TRYCC Q4DA83_TRYCC Q4DAY4_TRYCC Q4DAY4_TRYCC ITPA1_TRYCC ITPA1_TRYCC Q4DDS8_TRYCC Q4DDS8_TRYCC Q4DE37_TRYCC Q4DE37_TRYCC Q4DEE6_TRYCC Q4DEE6_TRYCC Q4DG65_TRYCC Q4DG65_TRYCC Q4DG77_TRYCC Q4DG77_TRYCC Q4DGA3_TRYCC Q4DGA3_TRYCC Q4DGD2_TRYCC Q4DGD2_TRYCC Q4DGE8_TRYCC Q4DGE8_TRYCC Q4DGU4_TRYCC Q4DGU4_TRYCC Q4DHI5_TRYCC Q4DHI5_TRYCC Q4DHP2_TRYCC Q4DHP2_TRYCC Q4DK98_TRYCC Q4DK98_TRYCC FEN1 FEN1 Q4DL91_TRYCC Q4DL91_TRYCC Q4DLI9_TRYCC Q4DLI9_TRYCC PURA1_TRYCC PURA1_TRYCC Q4DNU8_TRYCC Q4DNU8_TRYCC Q4DPN0_TRYCC Q4DPN0_TRYCC Q4DPS5_TRYCC Q4DPS5_TRYCC Q4DPV1_TRYCC Q4DPV1_TRYCC Q4DQV0_TRYCC Q4DQV0_TRYCC Q4DRC4_TRYCC Q4DRC4_TRYCC ITPA2_TRYCC ITPA2_TRYCC Q4DSF6_TRYCC Q4DSF6_TRYCC Q4DSM1_TRYCC Q4DSM1_TRYCC Q4DT76_TRYCC Q4DT76_TRYCC Q4DU82_TRYCC Q4DU82_TRYCC Q4DW49_TRYCC Q4DW49_TRYCC Q4DX52_TRYCC Q4DX52_TRYCC Q4DXI9_TRYCC Q4DXI9_TRYCC Q4DXT8_TRYCC Q4DXT8_TRYCC Q4DZ98_TRYCC Q4DZ98_TRYCC Q4DZU4_TRYCC Q4DZU4_TRYCC Q4E0Q0_TRYCC Q4E0Q0_TRYCC Q4E1U3_TRYCC Q4E1U3_TRYCC Q4E3P5_TRYCC Q4E3P5_TRYCC Q4E4K4_TRYCC Q4E4K4_TRYCC Q4E4L7_TRYCC Q4E4L7_TRYCC Q4E4N2_TRYCC Q4E4N2_TRYCC Q4E575_TRYCC Q4E575_TRYCC Q4E576_TRYCC Q4E576_TRYCC TRS TRS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pfkATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (485 aa)
Q4CNY1_TRYCCPlasma membrane ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. (484 aa)
Q4CQ52_TRYCCPlasma membrane ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. (646 aa)
Q4CR01_TRYCCMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (453 aa)
Q4CSB9_TRYCCMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (352 aa)
Q4CSC4_TRYCCS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (394 aa)
Q4CSE9_TRYCCProtein phosphatase; Belongs to the PP2C family. (282 aa)
PURA2_TRYCCAdenylosuccinate synthetase 2; Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). (616 aa)
Q4CXU8_TRYCCProtein phosphatase; Belongs to the PP2C family. (329 aa)
Q4CZ09_TRYCCMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (453 aa)
Q4D043_TRYCCProtein phosphatase; Belongs to the PP2C family. (329 aa)
Q4D0A7_TRYCCMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa)
Q4D161_TRYCCTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1198 aa)
Q4D3A0_TRYCCMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (362 aa)
Q4D3Y2_TRYCCMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (252 aa)
Q4D434_TRYCCPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1099 aa)
Q4D526_TRYCCGlutathione synthetase. (535 aa)
Q4D6K7_TRYCCRibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (323 aa)
Q4D790_TRYCCRibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (323 aa)
Q4D7R4_TRYCCGlutathione synthetase. (535 aa)
Q4D911_TRYCCPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1356 aa)
Q4D9Z4_TRYCCPyruvate kinase; Belongs to the pyruvate kinase family. (499 aa)
Q4DA33_TRYCCPhosphoacetylglucosamine mutase. (610 aa)
Q4DA83_TRYCCPoly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (645 aa)
Q4DAY4_TRYCCInositol-1-monophosphatase. (363 aa)
ITPA1_TRYCCInosine triphosphate pyrophosphatase 1; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (196 aa)
Q4DDS8_TRYCCDNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. (401 aa)
Q4DE37_TRYCCPlasma membrane ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. (898 aa)
Q4DEE6_TRYCCPhosphomannomutase-like protein, putative; Belongs to the phosphohexose mutase family. (585 aa)
Q4DG65_TRYCCIsocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (433 aa)
Q4DG77_TRYCCProtein phosphatase; Belongs to the PP2C family. (281 aa)
Q4DGA3_TRYCCHypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (221 aa)
Q4DGD2_TRYCCPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1099 aa)
Q4DGE8_TRYCCFanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1004 aa)
Q4DGU4_TRYCCProtein phosphatase; Belongs to the PP2C family. (363 aa)
Q4DHI5_TRYCCPhosphoacetylglucosamine mutase. (610 aa)
Q4DHP2_TRYCCMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (506 aa)
Q4DK98_TRYCCCation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1246 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (393 aa)
Q4DL91_TRYCCPPM-type phosphatase domain-containing protein. (1576 aa)
Q4DLI9_TRYCCPhosphoglucomutase, putative; Belongs to the phosphohexose mutase family. (600 aa)
PURA1_TRYCCAdenylosuccinate synthetase 1; Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). (616 aa)
Q4DNU8_TRYCCPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (533 aa)
Q4DPN0_TRYCCDNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. (522 aa)
Q4DPS5_TRYCCInositol-1-monophosphatase. (283 aa)
Q4DPV1_TRYCCPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1259 aa)
Q4DQV0_TRYCCPhosphoglucomutase, putative; Belongs to the phosphohexose mutase family. (600 aa)
Q4DRC4_TRYCCHypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (241 aa)
ITPA2_TRYCCInosine triphosphate pyrophosphatase 2; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (196 aa)
Q4DSF6_TRYCCPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1143 aa)
Q4DSM1_TRYCCPPM-type phosphatase domain-containing protein. (1576 aa)
Q4DT76_TRYCCPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1217 aa)
Q4DU82_TRYCCTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (672 aa)
Q4DW49_TRYCCSuccinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (418 aa)
Q4DX52_TRYCCPhosphomannomutase-like protein, putative; Belongs to the phosphohexose mutase family. (585 aa)
Q4DXI9_TRYCCPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1217 aa)
Q4DXT8_TRYCCTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1207 aa)
Q4DZ98_TRYCCEnolase, putative. (429 aa)
Q4DZU4_TRYCCFanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1006 aa)
Q4E0Q0_TRYCCPyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (913 aa)
Q4E1U3_TRYCCPyruvate kinase; Belongs to the pyruvate kinase family. (499 aa)
Q4E3P5_TRYCCPyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (913 aa)
Q4E4K4_TRYCCRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (330 aa)
Q4E4L7_TRYCCIsocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (413 aa)
Q4E4N2_TRYCCProtein phosphatase, putative. (407 aa)
Q4E575_TRYCCProtein phosphatase 2C, putative. (286 aa)
Q4E576_TRYCCProtein phosphatase 2C, putative. (316 aa)
TRSTrypanothione synthetase; Bifunctional enzyme which catalyzes the formation of trypanothione (N(1),N(8)-bis(glutathionyl)spermidine) from glutathione and spermidine. Converts spermidine or glutathionylspermidine into trypanothione. Can also convert aminopropylcadaverine into glutothionylaminopropylcadaverine and homotrypanothione. Also has low amidase activity, hydrolyzing trypanothione, homotrypanothione or glutathionylspermidine to form glutathione and the corresponding polyamine; In the C-terminal section; belongs to the glutathionylspermidine synthase preATP-grasp family. (647 aa)
Your Current Organism:
Trypanosoma cruzi
NCBI taxonomy Id: 353153
Other names: T. cruzi strain CL Brener, Trypanosoma cruzi strain CL Brener
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.